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GENE：FLT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FLT1
FullNmae fms related receptor tyrosine kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3763
EnsembleID ENSG00000102755
Uniprot P17948

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FLT1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FLT1 GO:0001525,GO:0002548,GO:0004714,GO:0005021,GO:0005021,GO:0005021,GO:0005515,GO:0005524,GO:0005615,GO:0005768,GO:0005886,GO:0005886,GO:0005925,GO:0007169,GO:0007275,GO:0008284,GO:0010863,GO:0015629,GO:0016477,GO:0018108,GO:0019838,GO:0030154,GO:0030335,GO:0033674,GO:0035924,GO:0036323,GO:0036332,GO:0038084,GO:0043235,GO:0043235,GO:0043406,GO:0043410,GO:0043552,GO:0045766,GO:0046777,GO:0048010,GO:0048010,GO:0048514,GO:0048598,GO:0051897,GO:1905563,GO:1990384

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FLT1 hsa:2321 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FLT1 hsa:2321 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
FLT1 hsa:2321 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
FLT1 hsa:2321 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
FLT1 hsa:2321 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
FLT1 hsa:2321 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
FLT1 hsa:2321 path:hsa04510 Focal adhesion - Homo sapiens (human)
FLT1 hsa:2321 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
FLT1 hsa:2321 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
VEGFA FLT1 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16076871 16572188 17086423 19414323 21372296 22064427 22461508 23390297 24217602 24346288 25922287 26192618 26201938 8837607 9157999 9570538 9753319 association N/A ACSN
VEGFB FLT1 10022831 10409677 11166270 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16076871 16572188 17086423 18988627 19414323 21071413 21372296 22064427 22461508 23331499 23390297 24217602 24346288 25922287 26192618 26201938 8837607 9157999 9570538 9751730 9753319 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
FLT1 PLCG1 10022831 11166270 11312102 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16076871 16572188 17086423 18988627 19414323 21372296 22064427 22461508 23331499 23390297 24217602 24346288 25922287 26192618 26201938 8837607 9157999 9299537 9398617 9570538 9600074 9753319 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
FLT1 GRB2 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26192618 26201938 26552706 8551221 8837607 9157999 9570538 9753319 interaction type N/A ACSN
FLT1 SHC1 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26192618 26201938 26552706 8551221 8837607 9157999 9570538 9753319 interaction type N/A ACSN
FLT1 STAT3 15703780 23180781 physical association anti tag coimmunoprecipitation InnateDB
FLT1 STAT1 15703780 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 FLT1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
EGR1 FLT1 10828020 18971253 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ETS1 FLT1 10554042 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FLT1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FLT1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 FLT1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 FLT1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 FLT1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FLT1 18971253 20516113 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 FLT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 FLT1 7499271 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 FLT1 7499271 trascriptional regulation,stimulation inferred by curator TFlink
EPAS1 FLT1 15192019 19616846 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 FLT1 17242190 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FLT1 16432214 1724219 trascriptional regulation,stimulation inferred by curator TFlink
ERG FLT1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS2 FLT1 N/A trascriptional regulation,stimulation inferred by curator TFlink
HIF1A FLT1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A405B FLT1 22955733 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000012A1DD FLT1 21544626 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000171525 FLT1 22569286 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000012A1DD FLT1 21544626 25416803 27373709 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001A405B FLT1 22955733 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000171525 FLT1 22569286 22735571 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000338542 FLT1 21310411 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00005CCD18 FLT1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 FLT1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 FLT1 23313552 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000033EBB8 FLT1 23313552 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 FLT1 23313552 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FLT1 FLT1 22135298 phosphorylation N/A PhosphoSite
STAT3 FLT1 25361965 interaction type N/A PTMCode2
FLT1 STAT3 25361965 interaction type N/A PTMCode2
KDR FLT1 25361965 interaction type N/A PTMCode2
FLT1 KDR 25361965 interaction type N/A PTMCode2
CBL FLT1 25361965 interaction type N/A PTMCode2
FLT1 CBL 25361965 interaction type N/A PTMCode2
SHC2 FLT1 25361965 interaction type N/A PTMCode2
FLT1 SHC2 25361965 interaction type N/A PTMCode2
FLT1 NCK1 25361965 interaction type N/A PTMCode2
NCK1 FLT1 25361965 interaction type N/A PTMCode2
FLT1 CRK 25361965 interaction type N/A PTMCode2
CRK FLT1 25361965 interaction type N/A PTMCode2
FLT1 PTK2B 25361965 interaction type N/A PTMCode2
PTK2B FLT1 25361965 interaction type N/A PTMCode2
FLT1 GRB2 25361965 interaction type N/A PTMCode2
GRB2 FLT1 25361965 interaction type N/A PTMCode2
FLT1 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 FLT1 25361965 interaction type N/A PTMCode2
FLT1 SHC1 25361965 interaction type N/A PTMCode2
SHC1 FLT1 25361965 interaction type N/A PTMCode2
PIK3R1 FLT1 25361965 interaction type N/A PTMCode2
FLT1 PIK3R1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YES1 FLT1 12509223 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
STAT1 FLT1 14525934 15703780 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CRK FLT1 14525934 23397142 24234451 25348397 9722576 physical association experimental interaction detection,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CBL FLT1 18273061 24234451 25348397 N/A isothermal titration calorimetry,physical interaction ComPPI,IntAct
PTK2B FLT1 11751905 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3R1 FLT1 23397142 24234451 25348397 7657594 association,physical association coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
PTPN11 FLT1 14525934 23397142 24234451 25348397 9600074 physical association two hybrid,physical interaction,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
CRKL FLT1 23397142 24234451 25348397 physical association anti tag coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
FLT1 KDR 10865839 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FLT1 VEGFA 10543948 14525934 17051153 20660291 24234451 25348397 8621427 9393862 physical association biophysical,coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,biochemical,enzyme linked immunosorbent assay,genetic,in vitro,in vivo ComPPI,HPRD,IntAct
FLT1 PLCG2 25348397 N/A two hybrid,in vitro ComPPI
FLT1 SHC1 10749680 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
FLT1 PGF 14525934 14684734 20660291 24234451 25348397 9452434 physical association coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vitro ComPPI,HPRD,IntAct
FLT1 VEGFB 14525934 25348397 9751730 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FLT1 ATR 10749680 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
FLT1 NCK1 14525934 25348397 9600074 N/A two hybrid,two hybrid ComPPI,HPRD
FLT1 NRP2 11278319 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FLT1 GRB2 14525934 25348397 9722576 N/A experimental interaction detection,in vivo ComPPI,HPRD
FLT1 CTNNB1 12920240 14525934 23397142 24234451 25348397 physical association experimental interaction detection,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
FLT1 FYN 12509223 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
FLT1 STAT3 14525934 15703780 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FLT1 HSPG2 21596751 24234451 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
FLT1 SHC2 25348397 N/A physical interaction ComPPI
FLT1 PLCG1 11312102 14525934 23397142 24234451 25348397 9299537 9398617 9600074 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
FLT1 NEDD4 25348397 N/A physical interaction ComPPI
FLT1 SRPK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
FLT1 SCGB2A2 25348397 N/A physical interaction ComPPI
FLT1 LDLR 17962812 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
FLT1 PTPRJ 12771128 16893970 24234451 25348397 dephosphorylation reaction biochemical ComPPI,IntAct
FLT1 PTPRB 22016384 24234451 25348397 27898060 physical association affinity chromatography technology,affinity technology ComPPI,IntAct,OmniPath
FLT1 PTK2 23397142 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
FLT1 HCK 23397142 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
FLT1 NRP1 10842181 14525934 23452854 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection ComPPI,HPRD,IntAct
FLT1 LGALS1 24234451 24529377 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FLT1 EEA1 23799140 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
PKM FLT1 25348397 N/A protein kinase assay ComPPI
FLT1 FLT1 11513746 14525934 N/A experimental interaction detection HPRD
FLT1 PLCG1 11312102 23397142 27898060 9299537 9398617 9600074 stimulant N/A OmniPath
CSNK1A1 FLT1 11741094 27898060 9398617 N/A N/A OmniPath
FLT1 EGR1 27898060 8662759 N/A N/A OmniPath
VEGFA FLT1 10543948 14704231 17051153 20660291 27898060 8356051 8621427 8631822 9393862 stimulant N/A OmniPath
STAT1 FLT1 15703780 27898060 N/A N/A OmniPath
PTPN11 FLT1 23397142 27898060 9600074 N/A N/A OmniPath
STAT3 FLT1 15703780 27898060 N/A N/A OmniPath
VEGFB FLT1 10409677 27898060 9751730 stimulant N/A OmniPath
PTPRJ FLT1 12771128 16893970 27898060 inhibition N/A OmniPath
PIGF FLT1 27898060 7929268 N/A N/A OmniPath

Visualization










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