Gene Information gene info

  1. Home

GENE：FOXP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FOXP3
FullNmae forkhead box P3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6106
EnsembleID ENSG00000049768
Uniprot Q9BZS1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FOXP3 pyroptosis 38404710 A tissue array was used to verify the expression of six pyroptosis-related genes (PRGs) , CD274, CD163 and FoxP3. C12orf75, VCAN, RGS2, MKNK2, SOCS3 and TNFAIP2 were successfully screened out to establish a signature to potently predict the survival time of GC patients. retulator signature
FOXP3 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature retulator signature

Go Annotation:

GeneSymbol Go id
FOXP3 GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001782,GO:0001818,GO:0002262,GO:0002362,GO:0002456,GO:0002513,GO:0002667,GO:0002669,GO:0002677,GO:0002725,GO:0002725,GO:0002851,GO:0002870,GO:0003677,GO:0003700,GO:0003700,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006355,GO:0006357,GO:0006366,GO:0006954,GO:0008285,GO:0009615,GO:0014045,GO:0032088,GO:0032496,GO:0032689,GO:0032689,GO:0032693,GO:0032700,GO:0032703,GO:0032703,GO:0032713,GO:0032714,GO:0032715,GO:0032720,GO:0032753,GO:0032792,GO:0032831,GO:0032905,GO:0032914,GO:0032991,GO:0033080,GO:0033092,GO:0035035,GO:0035739,GO:0042110,GO:0042130,GO:0042130,GO:0042803,GO:0042803,GO:0042826,GO:0043029,GO:0043433,GO:0043565,GO:0045066,GO:0045591,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0045893,GO:0045944,GO:0046007,GO:0046872,GO:0048289,GO:0048294,GO:0048302,GO:0050687,GO:0050777,GO:0050852,GO:0051059,GO:0051525,GO:1901355,GO:1990837,GO:2000320,GO:2000562

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FOXP3 hsa:50943 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
FOXP3 hsa:50943 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DEPTOR FOXP3 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 FOXP3 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MTOR FOXP3 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR FOXP3 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
TNF FOXP3 11112697 12646658 1431106 14607933 14625680 15099563 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26192618 26201938 8910423 interaction type N/A ACSN
IFNG FOXP3 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
HIF1A FOXP3 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 26192618 interaction type N/A ACSN
MAP3K7 FOXP3 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845 26192618 interaction type N/A ACSN
VSIR FOXP3 24691993 26192618 interaction type N/A ACSN
FOXP3 CTLA4 12522256 17237765 17449799 21411734 26192618 interaction type N/A ACSN
NFATC1 FOXP3 19564342 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 FOXP3 18641303 23180781 physical association affinity chromatography technology InnateDB
SMAD1 FOXP3 20676092 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKZF3 FOXP3 20676092 23180781 physical association anti tag coimmunoprecipitation InnateDB
RORA FOXP3 18354202 23180781 physical association two hybrid InnateDB
FOXP3 IL2 22806628 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT5B FOXP3 23180781 24497979 physical association anti tag coimmunoprecipitation InnateDB
IL2 FOXP3 23180781 23954131 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
FOXP3 FOXP3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
IRF1 FOXP3 18641303 trascriptional regulation,stimulation inferred by curator TFlink
MSC FOXP3 19561533 trascriptional regulation,stimulation inferred by curator TFlink
NFATC2 FOXP3 16517728 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 FOXP3 20462637 trascriptional regulation,stimulation inferred by curator TFlink
PGR FOXP3 18685848 trascriptional regulation,stimulation inferred by curator TFlink
RELA FOXP3 20462637 23178569 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 FOXP3 21533107 trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 FOXP3 20937549 trascriptional regulation,stimulation inferred by curator TFlink
SP3 FOXP3 20462637 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 FOXP3 19124747 trascriptional regulation,stimulation inferred by curator TFlink
VDR FOXP3 22529297 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000001EB3 FOXP3 19408243 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 FOXP3 18927107 19408243 24855107 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000055128B FOXP3 24316592 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D FOXP3 25416803 26383248 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B FOXP3 22135298 phosphorylation N/A PhosphoSite
LCK FOXP3 22135298 phosphorylation N/A PhosphoSite
PIM1 FOXP3 22135298 phosphorylation N/A PhosphoSite
HDAC7 FOXP3 25361965 interaction type N/A PTMCode2
FOXP3 HDAC7 25361965 interaction type N/A PTMCode2
RUNX1 FOXP3 25361965 interaction type N/A PTMCode2
FOXP3 RUNX1 25361965 interaction type N/A PTMCode2
IKZF4 FOXP3 25361965 interaction type N/A PTMCode2
FOXP3 IKZF4 25361965 interaction type N/A PTMCode2
FOXP3 NFATC2 25361965 interaction type N/A PTMCode2
NFATC2 FOXP3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RBPMS FOXP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSPA8 FOXP3 23973223 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KRTAP8-1 FOXP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRR20E FOXP3 24234451 25348397 25910212 physical association physical interaction,two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
PRR20C FOXP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRR20D FOXP3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP3-3 FOXP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
REL FOXP3 25348397 N/A physical interaction ComPPI
NFATC1 FOXP3 25348397 N/A physical interaction ComPPI
EP300 FOXP3 16652169 19996091 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HDAC4 FOXP3 25348397 N/A physical interaction ComPPI
HIPK1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HSPA1A FOXP3 23973223 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
HSPA1B FOXP3 25348397 N/A physical interaction ComPPI
FEN1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PSMA5 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PPP1CA FOXP3 23396208 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
NFATC2 FOXP3 14525934 15790681 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TNF FOXP3 24234451 25348397 25712342 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RELA FOXP3 24234451 25348397 25712342 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIVA1 FOXP3 21955384 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HDAC2 FOXP3 19276356 22922362 24234451 25348397 25609649 27898060 association physical interaction,tandem affinity purification ComPPI,IntAct,OmniPath
H1-5 FOXP3 21654845 25348397 27898060 N/A physical interaction ComPPI,OmniPath
WRNIP1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TFCP2 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TRIM28 FOXP3 23543754 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
IKZF3 FOXP3 20676092 22922362 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SMC3 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SIRT1 FOXP3 25348397 N/A physical interaction ComPPI
USP11 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ZBTB33 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HDAC9 FOXP3 17360565 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HDAC7 FOXP3 17360565 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RORA FOXP3 18354202 24234451 25348397 27898060 physical association two hybrid ComPPI,IntAct,OmniPath
NRF1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NUP133 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SATB1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
STUB1 FOXP3 23973223 24234451 25348397 ubiquitination reaction,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy,ubiquitinase assay ComPPI,IntAct
PSMB4 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NOVA1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RALY FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
IKZF4 FOXP3 19696312 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NUP107 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SUGP2 FOXP3 25348397 N/A physical interaction ComPPI
NFAT5 FOXP3 14525934 15790681 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FOXP4 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP2 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SATB2 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CDC27 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 RUNX1 14525934 17377532 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
FOXP3 KAT5 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
FOXP3 KAT8 25348397 N/A physical interaction ComPPI
FOXP3 HDAC1 25348397 N/A physical interaction ComPPI
FOXP3 GATA3 25348397 N/A physical interaction ComPPI
FOXP3 FOXA3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 HOXD13 25348397 N/A physical interaction ComPPI
FOXP3 AKAP8 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 FUBP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ESRP2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 CCAR2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ZBTB34 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ZBTB37 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ZFR 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ADAR 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ELP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 SMC2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 HOXC13 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 P4HA1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 CENPB 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 NACC1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 NACC2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 NOVA2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 NUP160 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 UBP1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ZNF326 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 ALB 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 FOXR1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 SMYD2 25348397 N/A physical interaction ComPPI
FOXP3 CDC23 25348397 N/A physical interaction ComPPI
FOXP3 RORC 18368049 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXP3 KRTAP6-2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FOXP3 FOSB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BEND3 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXP3 FOXP3 24234451 25609649 association tandem affinity purification IntAct
FOXP3 IFNG 23543754 24234451 association chromatin immunoprecipitation assay IntAct
LCK FOXP3 24155921 27898060 inhibition N/A OmniPath
STAT5A FOXP3 18270368 27898060 stimulant N/A OmniPath
PIM1 FOXP3 25096571 27898060 N/A N/A OmniPath
SMAD3 FOXP3 15367216 19701891 27898060 stimulant N/A OmniPath
NFATC1 FOXP3 15790681 19564342 21490927 27898060 N/A N/A OmniPath

Visualization










  Return