GENE：G6PD
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | G6PD |
| FullNmae | glucose-6-phosphate dehydrogenase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4057 |
| EnsembleID | ENSG00000160211 |
| Uniprot | P11413 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| G6PD | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| G6PD | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| G6PD | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| G6PD | GO:0004345,GO:0004345,GO:0004345,GO:0005515,GO:0005536,GO:0005536,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006006,GO:0006098,GO:0006629,GO:0006695,GO:0006739,GO:0006740,GO:0006749,GO:0009051,GO:0009051,GO:0009898,GO:0010041,GO:0010734,GO:0014070,GO:0016020,GO:0019322,GO:0021762,GO:0032094,GO:0034451,GO:0034599,GO:0042802,GO:0042803,GO:0043231,GO:0043249,GO:0043523,GO:0045471,GO:0046390,GO:0050661,GO:0051156,GO:0051156,GO:0061052,GO:0070062,GO:1904879,GO:2000378 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| G6PD | hsa:2539 | path:hsa00030 | Pentose phosphate pathway - Homo sapiens (human) |
| G6PD | hsa:2539 | path:hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| G6PD | hsa:2539 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| G6PD | hsa:2539 | path:hsa01200 | Carbon metabolism - Homo sapiens (human) |
| G6PD | hsa:2539 | path:hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| G6PD | hsa:2539 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | G6PD | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | G6PD | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| VDR | G6PD | 18348143 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | G6PD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | G6PD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | G6PD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | G6PD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREM | G6PD | 17273168 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | G6PD | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | G6PD | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | G6PD | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001A7F58 | G6PD | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000034B6F5 | G6PD | 23921124 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00000C4DB5 | G6PD | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A9CF | G6PD | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | G6PD | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076E54 | G6PD | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0B46 | G6PD | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E728C | G6PD | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDC73 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| PAK2 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| BAG3 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| LDHB | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| CDA | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| YWHAG | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| PPP1R2B | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| MCM2 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| BLMH | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| EIF5 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| SLC9A3R1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| TGM2 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| DUT | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| YWHAB | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| ARFIP1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| PGD | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| IDH2 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| VCL | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| NDRG1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| CTR9 | G6PD | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| XPO1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| YWHAQ | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| RPE | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| YWHAH | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| SFN | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| YWHAE | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| HSPB1 | G6PD | 21157431 24234451 25348397 26344197 27898060 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct,OmniPath |
| SIRT2 | G6PD | 24234451 24769394 25348397 27898060 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| HSPA9 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| FDPS | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| RAD23B | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| COMMD1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| MYO6 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| ZNF622 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| MAT2B | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| PPP1R2 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| CAPN1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| UBE2V1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G10 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| UNC13D | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| CAT | G6PD | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| CNDP2 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| MED18 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| ERP44 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| CKB | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | SUMO4 | 14525934 16236267 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| G6PD | HARS1 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | CCT4 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | FN1 | 19738201 24234451 25348397 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| G6PD | ALDH7A1 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | EIF4H | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | GNS | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | GBP2 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | GLA | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | UBFD1 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | ZFYVE19 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | CA10 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | PPAT | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | ARMT1 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | SEPHS1 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | GFUS | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | PDXK | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | PGAM1 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | TANGO2 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | UFM1 | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | SBF2 | 25348397 | N/A | physical interaction | ComPPI |
| ISOC1 | G6PD | 25348397 | N/A | physical interaction | ComPPI |
| HSCB | G6PD | 24234451 25348397 28380382 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| G6PD | G6PD | 10089300 10745013 14525934 24234451 24769394 25416956 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,two hybrid array | HPRD,IntAct |
| H1-2 | G6PD | 24234451 30021884 | physical association | cross-linking study | IntAct |
| SRC | G6PD | 19359662 27898060 | N/A | N/A | OmniPath |
| PRKCD | G6PD | 20649491 27898060 | stimulant | N/A | OmniPath |