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GENE：GADD45B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GADD45B
FullNmae growth arrest and DNA damage inducible beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4096
EnsembleID ENSG00000099860
Uniprot O75293

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GADD45B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GADD45B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GADD45B GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0006915,GO:0030154,GO:0043065,GO:0046330,GO:0051726,GO:1900745

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GADD45B hsa:4616 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
GADD45B hsa:4616 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
GADD45B hsa:4616 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
GADD45B hsa:4616 path:hsa04110 Cell cycle - Homo sapiens (human)
GADD45B hsa:4616 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
GADD45B hsa:4616 path:hsa04210 Apoptosis - Homo sapiens (human)
GADD45B hsa:4616 path:hsa04218 Cellular senescence - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05200 Pathways in cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05210 Colorectal cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05213 Endometrial cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05214 Glioma - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05216 Thyroid cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05218 Melanoma - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05224 Breast cancer - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
GADD45B hsa:4616 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GADD45B MAP3K4 11175814 14691480 23180781 24104473 26192618 9827804 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
GADD45B ELAVL1 19289500 23180781 physical association anti tag coimmunoprecipitation InnateDB
GADD45B EGR1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F1 GADD45B 23180781 24912499 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GADD45B MAP2K7 20005715 interaction type N/A PSP
GADD45B ESR1 20005715 interaction type N/A PSP
GADD45B PCNA 20005715 interaction type N/A PSP
GADD45B PPARG 20005715 interaction type N/A PSP
GADD45B PPARD 20005715 interaction type N/A PSP
GADD45B MAP3K5 20005715 interaction type N/A PSP
GADD45B MAP3K4 20005715 interaction type N/A PSP
GADD45B ESR1 10872826 18988627 20005715 20005715 N/A N/A SignaLink
GADD45B MAP2K7 20005715 20005715 N/A N/A SignaLink
GADD45B MAP3K4 14743220 16256071 18988627 20005715 20005715 21071413 9827804 9827804 9827804 N/A N/A SignaLink
GADD45B MAP3K5 14743220 18988627 20005715 20005715 N/A N/A SignaLink
GADD45B PPARD 10872826 18988627 20005715 20005715 N/A N/A SignaLink
GADD45B PPARG 10872826 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 GADD45B 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 GADD45B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR1I2 GADD45B 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GADD45B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AR GADD45B N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA GADD45B N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARD GADD45B N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG GADD45B N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA GADD45B N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 GADD45B N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 GADD45B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
GADD45G GADD45B 11498536 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PCNA GADD45B 10828065 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CDKN1A GADD45B 14525934 25348397 27898060 8700517 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
POLR3C GADD45B 25348397 N/A physical interaction ComPPI
HBA1 GADD45B 25348397 N/A physical interaction ComPPI
PPARA GADD45B 25348397 N/A in vitro ComPPI
GADD45B PPARD 10872826 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GADD45B PPARG 10872826 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GADD45B MAP3K4 12052864 14525934 14743220 16256071 24234451 25348397 9827804 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,dihydrofolate reductase reconstruction,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
GADD45B GADD45GIP1 12716909 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GADD45B CCNB1 12124778 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GADD45B MAP2K7 14743220 24234451 25314077 25348397 27898060 physical association anti tag coimmunoprecipitation,circular dichroism,physical interaction,in vitro,in vivo,solid phase assay ComPPI,IntAct,OmniPath
GADD45B MAP3K5 14525934 14743220 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GADD45B ESR1 10872826 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GADD45B GADD45A 25348397 N/A physical interaction ComPPI
GADD45B CDK1 10973963 14525934 24234451 25348397 27626412 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
GADD45B CNOT2 25348397 N/A physical interaction ComPPI
GADD45B CNOT6 25348397 N/A physical interaction ComPPI
GADD45B IL36A 25348397 N/A physical interaction ComPPI
GADD45B CNOT6L 25348397 N/A physical interaction ComPPI
GADD45B CNOT8 25348397 N/A physical interaction ComPPI
GADD45B CNOT11 25348397 N/A physical interaction ComPPI
GADD45B CNOT1 25348397 N/A physical interaction ComPPI
GADD45B CNOT10 25348397 N/A physical interaction ComPPI
GADD45B CNOT9 25348397 N/A physical interaction ComPPI
GADD45B TNKS1BP1 25348397 N/A physical interaction ComPPI
GADD45B CNOT3 25348397 N/A physical interaction ComPPI
GADD45B CNOT7 25348397 N/A physical interaction ComPPI
GADD45B RAVER1 25348397 N/A physical interaction ComPPI
GADD45B MAP2K6 12052864 24234451 25348397 physical association dihydrofolate reductase reconstruction ComPPI,IntAct
GADD45B EFHC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45B MAP3K4 14743220 16256071 27898060 9827804 stimulant N/A OmniPath

Visualization










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