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GENE：GATA3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GATA3
FullNmae GATA binding protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4172
EnsembleID ENSG00000107485
Uniprot P23771

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GATA3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GATA3 GO:0000122,GO:0000785,GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0000987,GO:0001223,GO:0001227,GO:0001228,GO:0001701,GO:0001709,GO:0001764,GO:0001817,GO:0001822,GO:0001823,GO:0002088,GO:0002520,GO:0002572,GO:0003180,GO:0003215,GO:0003281,GO:0003677,GO:0003700,GO:0003700,GO:0005134,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006338,GO:0006366,GO:0006952,GO:0006954,GO:0006959,GO:0007165,GO:0007411,GO:0008270,GO:0008285,GO:0008584,GO:0009615,GO:0009653,GO:0009791,GO:0009967,GO:0010595,GO:0010719,GO:0010975,GO:0030101,GO:0030217,GO:0030218,GO:0030225,GO:0030856,GO:0031929,GO:0032689,GO:0032703,GO:0032736,GO:0032736,GO:0032753,GO:0032754,GO:0033600,GO:0035162,GO:0035457,GO:0035799,GO:0035898,GO:0042421,GO:0042472,GO:0042802,GO:0043491,GO:0043523,GO:0043583,GO:0043627,GO:0045061,GO:0045064,GO:0045087,GO:0045165,GO:0045582,GO:0045622,GO:0045786,GO:0045892,GO:0045893,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0045944,GO:0048469,GO:0048485,GO:0048538,GO:0048568,GO:0048589,GO:0048646,GO:0050728,GO:0050852,GO:0051216,GO:0051897,GO:0060017,GO:0060037,GO:0060065,GO:0060231,GO:0060374,GO:0060676,GO:0061290,GO:0061629,GO:0070888,GO:0071353,GO:0071356,GO:0071599,GO:0071773,GO:0071837,GO:0072107,GO:0072178,GO:0072179,GO:0072182,GO:0072197,GO:0072676,GO:1901536,GO:1902895,GO:1990837,GO:2000114,GO:2000146,GO:2000352,GO:2000553,GO:2000607,GO:2000611,GO:2000679,GO:2000683,GO:2000703,GO:2000734

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GATA3 hsa:2625 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
GATA3 hsa:2625 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
GATA3 hsa:2625 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
GATA3 hsa:2625 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA3 AR 17011549 23180781 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL13 GATA3 19080345 21849680 21989417 22039304 22226971 23180781 23796028 physical association anti tag coimmunoprecipitation InnateDB
IL4 GATA3 21849680 21989417 22039304 22226971 23180781 physical association anti tag coimmunoprecipitation InnateDB
GATA3 NFATC2 22226971 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
IL5 GATA3 21849680 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELAVL1 GATA3 21613615 23180781 physical association pull down InnateDB
GATA3 KPNA2 19080345 23180781 physical association anti tag coimmunoprecipitation InnateDB
GATA3 PRKACA 23180781 25479686 phosphorylation reaction protein kinase assay InnateDB
EZH2 GATA3 23180781 25479686 physical association anti tag coimmunoprecipitation InnateDB
GATA3 EZH2 23180781 25479686 physical association anti tag coimmunoprecipitation InnateDB
GATA3 PGR 23180781 25479686 physical association anti tag coimmunoprecipitation InnateDB
CCR3 GATA3 23180781 23636060 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IFNG 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL13 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 BATF 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 BCL6 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CXCR3 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 ETS1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 GFI1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 HOPX 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL4R 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL2RA 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IRF1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IKZF1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 MAF 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 PRDM1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 RBPJ 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 RUNX1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 STAT1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 STAT4 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 STAT5A 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL1R1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL1RL2 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL1RL1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL18R1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL18RAP 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CCR9 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CXCR6 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 XCR1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CCR1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CCR2 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CCR3 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CCR5 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 CCRL2 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 LMO1 23180781 9020185 physical association pull down InnateDB
GATA3 LMO2 23180781 9020185 physical association pull down InnateDB
GATA3 HDAC3 17075044 23180781 physical association anti tag coimmunoprecipitation InnateDB
GATA3 HDAC5 17075044 23180781 physical association anti tag coimmunoprecipitation InnateDB
GATA3 FUT7 17075044 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 GATA3 11790301 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 GATA3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 GATA3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 GATA3 19559773 20484083 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 GATA3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 GATA3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GATA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MEN1 GATA3 20484083 trascriptional regulation,stimulation inferred by curator TFlink
MYB GATA3 20484083 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 GATA3 20660789 trascriptional regulation,stimulation inferred by curator TFlink
RELA GATA3 20660789 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 GATA3 20126258 trascriptional regulation,stimulation inferred by curator TFlink
SP1 GATA3 15486968 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 GATA3 15486968 trascriptional regulation,stimulation inferred by curator TFlink
TBX21 GATA3 17075044 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 GATA3 22951069 trascriptional regulation,stimulation inferred by curator TFlink
AR GATA3 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 GATA3 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA GATA3 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG GATA3 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT1 GATA3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 GATA3 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00004AC389 GATA3 25074381 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001B341F GATA3 25416803 26834155 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000812128 GATA3 24297251 direct interaction,inhibition high throughput sequencing StarBase

Source Target Pmid Interactiontype Methods Database
PRKACA GATA3 22135298 phosphorylation N/A PhosphoSite
CDK2 GATA3 22135298 phosphorylation N/A PhosphoSite
SATB1 GATA3 25361965 interaction type N/A PTMCode2
GATA3 SATB1 25361965 interaction type N/A PTMCode2
TBX21 GATA3 25361965 interaction type N/A PTMCode2
GATA3 TBX21 25361965 interaction type N/A PTMCode2
HDAC5 GATA3 25361965 interaction type N/A PTMCode2
GATA3 HDAC5 25361965 interaction type N/A PTMCode2
HDAC3 GATA3 25361965 interaction type N/A PTMCode2
GATA3 HDAC3 25361965 interaction type N/A PTMCode2
LMO1 GATA3 25361965 interaction type N/A PTMCode2
GATA3 LMO1 25361965 interaction type N/A PTMCode2
LMO2 GATA3 25361965 interaction type N/A PTMCode2
GATA3 LMO2 25361965 interaction type N/A PTMCode2
ETS2 GATA3 25361965 interaction type N/A PTMCode2
GATA3 ETS2 25361965 interaction type N/A PTMCode2
GATA3 ZFPM2 25361965 interaction type N/A PTMCode2
ZFPM2 GATA3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RARA GATA3 24234451 25303530 25348397 association anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
STAT1 GATA3 24234451 25303530 25348397 association chromatin immunoprecipitation assay ComPPI,IntAct
RARB GATA3 25348397 N/A physical interaction ComPPI
BMI1 GATA3 25348397 N/A physical interaction ComPPI
EHMT2 GATA3 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
SP1 GATA3 18338249 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ETS2 GATA3 10212281 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LCK GATA3 24234451 25348397 26871637 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FBXW7 GATA3 24820417 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SPI1 GATA3 25348397 N/A physical interaction ComPPI
HDAC3 GATA3 17075044 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK14 GATA3 25348397 N/A physical interaction ComPPI
HDAC4 GATA3 25348397 N/A physical interaction ComPPI
PSMA3 GATA3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MED1 GATA3 11724781 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSP90AA1 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
VTN GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
C4A GATA3 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
PRMT5 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTN2 GATA3 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
STK38 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
RBBP4 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
JMJD1C GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
LMO2 GATA3 14525934 25348397 9819382 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TAL1 GATA3 14525934 21179004 24234451 25348397 9819382 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MDM2 GATA3 25348397 N/A physical interaction ComPPI
SOX4 GATA3 22751141 24234451 25348397 27898060 physical association pull down ComPPI,IntAct,OmniPath
CDK2 GATA3 25348397 N/A physical interaction ComPPI
LMO1 GATA3 14525934 25348397 9020185 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HDAC2 GATA3 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SPAG9 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
MTA3 GATA3 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
TFAP2C GATA3 24234451 25303530 25348397 association chromatin immunoprecipitation assay ComPPI,IntAct
HDAC5 GATA3 17075044 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ZFPM2 GATA3 14525934 14985365 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
FOXA1 GATA3 24234451 25303530 25348397 association physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
ESR1 GATA3 24234451 25303530 25348397 26153859 association,physical association anti tag coimmunoprecipitation,cross-linking study,chromatin immunoprecipitation assay ComPPI,IntAct
SATB1 GATA3 14525934 17057718 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
MBD3 GATA3 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
KDM1A GATA3 24234451 25348397 26028330 association anti bait coimmunoprecipitation ComPPI,IntAct
BRCA1 GATA3 25348397 N/A physical interaction ComPPI
ZEB2 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
KIF11 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
FOXP3 GATA3 25348397 N/A physical interaction ComPPI
ETS1 GATA3 10212281 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
USP21 GATA3 25348397 N/A physical interaction ComPPI
MMRN1 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
GATA3 TBX21 17075044 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GATA3 REPIN1 25348397 N/A physical interaction ComPPI
GATA3 MYB 25348397 N/A physical interaction ComPPI
GATA3 FOS 24234451 25303530 25348397 association chromatin immunoprecipitation assay ComPPI,IntAct
GATA3 RARG 24234451 25303530 25348397 association chromatin immunoprecipitation assay ComPPI,IntAct
GATA3 HDAC1 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
GATA3 SDAD1 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
GATA3 UBR3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
GREB1 GATA3 24234451 25303530 association chromatin immunoprecipitation assay IntAct
GATA3 FOXC1 24234451 25303530 association chromatin immunoprecipitation assay IntAct
VAPB GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
ACTR6 GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
AURKAIP1 GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
BCAS3 GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
ZNF217 GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
KMT2E GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
NCOA3 GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
CDH2 GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
GATA3 KPNA2 19080345 27898060 N/A N/A OmniPath
GATA3 NEUROD1 15003631 27898060 N/A N/A OmniPath
PRKACA GATA3 25479686 27898060 N/A N/A OmniPath
STAT6 GATA3 12947222 17312100 27898060 stimulant N/A OmniPath
GATA3 IL10 20154735 27898060 stimulant N/A OmniPath
ESR1 GATA3 10096242 27898060 stimulant N/A OmniPath
GATA3 CEBPB 15632071 27898060 inhibition N/A OmniPath
GATA3 FGF10 16806848 27898060 stimulant N/A OmniPath
GATA3 CEBPA 17139329 27898060 inhibition N/A OmniPath
SIX1 GATA3 12874121 27898060 stimulant N/A OmniPath
MYB GATA3 17641686 27898060 stimulant N/A OmniPath
SMAD3 GATA3 11790301 27898060 stimulant N/A OmniPath
ASH2L GATA3 25258321 27898060 stimulant N/A OmniPath

Visualization










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