GENE：GLA
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GLA |
| FullNmae | galactosidase alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4296 |
| EnsembleID | ENSG00000102393 |
| Uniprot | P06280 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GLA | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| GLA | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| GLA | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GLA | GO:0003824,GO:0004557,GO:0004557,GO:0004557,GO:0005102,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005737,GO:0005737,GO:0005764,GO:0005764,GO:0005794,GO:0009311,GO:0009311,GO:0016139,GO:0016787,GO:0016936,GO:0017041,GO:0017041,GO:0035578,GO:0042803,GO:0043202,GO:0045019,GO:0046477,GO:0046479,GO:0046479,GO:0046479,GO:0051001,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GLA | hsa:2717 | path:hsa00052 | Galactose metabolism - Homo sapiens (human) |
| GLA | hsa:2717 | path:hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| GLA | hsa:2717 | path:hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
| GLA | hsa:2717 | path:hsa00603 | Glycosphingolipid biosynthesis - globo and isoglobo series - Homo sapiens (human) |
| GLA | hsa:2717 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| GLA | hsa:2717 | path:hsa04142 | Lysosome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | GLA | 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| MYC | GLA | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | GLA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | GLA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GLA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | GLA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004E008F | GLA | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D5391 | GLA | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000486E0B | GLA | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047A67D | GLA | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F4AC3 | GLA | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AA464 | GLA | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020579D | GLA | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000913AC | GLA | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EIF5 | GLA | 25348397 | N/A | physical interaction | ComPPI |
| PTPN18 | GLA | 25348397 | N/A | physical interaction | ComPPI |
| PGD | GLA | 25348397 | N/A | physical interaction | ComPPI |
| CANX | GLA | 24234451 25348397 29568061 | association | pull down | ComPPI,IntAct |
| TERT | GLA | 25348397 | N/A | physical interaction | ComPPI |
| GABARAP | GLA | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ZNF622 | GLA | 25348397 | N/A | physical interaction | ComPPI |
| CAPN1 | GLA | 25348397 | N/A | physical interaction | ComPPI |
| CNOT2 | GLA | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| CNOT6 | GLA | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| EIF4H | GLA | 25348397 | N/A | physical interaction | ComPPI |
| G6PD | GLA | 25348397 | N/A | physical interaction | ComPPI |
| GBP2 | GLA | 25348397 | N/A | physical interaction | ComPPI |
| FBXO6 | GLA | 25348397 | N/A | physical interaction | ComPPI |
| OTUD4 | GLA | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RIPK4 | GLA | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |