GENE：GSDMD
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GSDMD |
| FullNmae | gasdermin D |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:25697 |
| EnsembleID | ENSG00000104518 |
| Uniprot | P57764 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GSDMD | pyroptosis | 37001609 | HK1 shRNA transfection further confirmed that HSYA inhibited the NLRP3/GSDMD-mediated pyroptosis via HK1 downregulation. | retulator signature |
| GSDMD | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| GSDMD | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GSDMD | GO:0001786,GO:0001786,GO:0005515,GO:0005546,GO:0005546,GO:0005576,GO:0005615,GO:0005654,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006954,GO:0009306,GO:0016020,GO:0022829,GO:0031668,GO:0031966,GO:0032731,GO:0035580,GO:0042742,GO:0045087,GO:0046931,GO:0050729,GO:0050829,GO:0050830,GO:0051260,GO:0055085,GO:0070269,GO:0070269,GO:0070269,GO:0070273,GO:0070273,GO:0070300,GO:0072559,GO:0072559,GO:1901612,GO:1904724,GO:1904813 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GSDMD | hsa:79792 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| GSDMD | hsa:79792 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| GSDMD | hsa:79792 | path:hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| GSDMD | hsa:79792 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | GSDMD | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | GSDMD | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | GSDMD | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | GSDMD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | GSDMD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | GSDMD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GSDMD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GSDMD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GSDMD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KCTD6 | GSDMD | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| GSDMD | CASP4 | 24234451 25348397 26375003 | protein cleavage | protease assay,protein cleavage | ComPPI,IntAct |
| GSDMD | PSMA1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| GSDMD | ZBTB33 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ZNF426 | GSDMD | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |