Gene Information gene info

GENE:GZMA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GZMA
FullNmae granzyme A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4708
EnsembleID ENSG00000145649
Uniprot P12544

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GZMA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GZMA GO:0001772,GO:0004252,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0006915,GO:0006955,GO:0009617,GO:0031640,GO:0032078,GO:0042803,GO:0043065,GO:0043065,GO:0043392,GO:0051354,GO:0051354,GO:0051603,GO:0051604,GO:0070269,GO:0140507,GO:1902483

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GZMA hsa:3001 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
M6PR GZMA 11081635 20634814 26192618 8432729 interaction type N/A ACSN
GZMA MT-ND1 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA MT-ND2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA MT-ND3 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA MT-ND4 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA MT-ND4L 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA MT-ND5 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA MT-ND6 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA1 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA10 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA11 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA12 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA13 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA3 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA4 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA5 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA6 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA7 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA8 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFA9 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFAB1 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB1 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB10 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB11 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB3 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB4 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB5 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB6 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB7 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB8 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFB9 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFC1 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFC2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS1 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS3 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS4 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS5 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS6 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS7 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFS8 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFV1 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFV2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
GZMA NDUFV3 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
PRKCQ GZMA 10652356 12811837 15214048 15536066 16606694 17544292 17548359 18784374 19201850 19833085 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
DEPTOR GZMA 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 GZMA 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MTOR GZMA 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR GZMA 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
GZMA SET 11555662 19059912 23180781 9256474 protein cleavage,physical association anti tag coimmunoprecipitation,enzymatic study,protease assay InnateDB
GZMA HSPB2 23180781 9647220 physical association anti tag coimmunoprecipitation InnateDB
ANP32A GZMA 23180781 9647220 protein cleavage protease assay InnateDB
A2M GZMA 10666226 23180781 physical association anti tag coimmunoprecipitation InnateDB
GZMA GZMA 10666226 12819769 18951048 19059912 23180781 physical association x-ray crystallography,comigration in non denaturing gel electrophoresis InnateDB
GZMA SERPINC1 10666226 23180781 physical association anti tag coimmunoprecipitation,solid phase assay InnateDB
SERPINC1 GZMA 10666226 23180781 physical association anti tag coimmunoprecipitation InnateDB
GZMA H1-4 11060286 23180781 protein cleavage enzymatic study,protease assay InnateDB
GZMA NR3C1 17180578 23180781 physical association anti tag coimmunoprecipitation InnateDB
XRCC6 GZMA 16440001 23180781 protein cleavage,physical association anti tag coimmunoprecipitation,pull down,protease assay InnateDB
GZMA XRCC5 16440001 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
APEX1 GZMA 12524539 23180781 protein cleavage,physical association anti tag coimmunoprecipitation,protease assay InnateDB
GZMA HNRNPK 19059912 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 GZMA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR3C1 GZMA 17180578 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GZMA 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GZMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GZMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GZMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
GZMA NCL 25361965 interaction type N/A PTMCode2
NCL GZMA 25361965 interaction type N/A PTMCode2
GZMA SET 25361965 interaction type N/A PTMCode2
SET GZMA 25361965 interaction type N/A PTMCode2
APEX1 GZMA 25361965 interaction type N/A PTMCode2
GZMA APEX1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK GZMA 25348397 N/A physical interaction ComPPI
GOLGA2 GZMA 25348397 N/A physical interaction ComPPI
ACTG1 GZMA 25348397 N/A physical interaction ComPPI
SET GZMA 11555662 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LMNA GZMA 25348397 N/A physical interaction ComPPI
HSP90AA1 GZMA 18485875 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC5 GZMA 25348397 N/A physical interaction ComPPI
HSPA1A GZMA 18485875 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HSPA1B GZMA 25348397 N/A anti bait coimmunoprecipitation ComPPI
GZMA LMNB1 11331782 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GZMA NDUFS3 18485875 24234451 25348397 protein cleavage physical interaction,protease assay ComPPI,IntAct
GZMA H1-1 25348397 N/A physical interaction ComPPI
GZMA H2BC21 25348397 N/A physical interaction ComPPI
GZMA HDC 25348397 N/A physical interaction ComPPI
GZMA XRCC6 25348397 N/A physical interaction ComPPI
GZMA APEX1 12524539 12555094 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GZMA HSPA4 25348397 N/A physical interaction ComPPI
GZMA HSP90AA2P 25348397 N/A physical interaction ComPPI
HMGB2 GZMA 11909973 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GZMA GZMA 12819770 14525934 24234451 covalent binding experimental interaction detection,x-ray crystallography HPRD,IntAct
NCL GZMA 14525934 1860869 27898060 N/A experimental interaction detection HPRD,OmniPath
H1-4 GZMA 11060286 27898060 N/A N/A OmniPath
GZMA HMGB2 11909973 17008916 27898060 inhibition N/A OmniPath
GZMA APEX1 12524539 12555094 27898060 inhibition,stimulant N/A OmniPath
GZMA SET 11555662 19059912 19254476 27898060 9256474 inhibition N/A OmniPath
GZMA IL1B 19254476 27898060 stimulant N/A OmniPath
GZMA LMNB1 11331782 27898060 N/A N/A OmniPath

Visualization