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GENE：HLA-DRB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HLA-DRB1
FullNmae major histocompatibility complex, class II, DR beta 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4948
EnsembleID ENSG00000196126
Uniprot P01911

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HLA-DRB1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HLA-DRB1 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature

Go Annotation:

GeneSymbol Go id
HLA-DRB1 GO:0000139,GO:0001772,GO:0001916,GO:0001934,GO:0002437,GO:0002469,GO:0002491,GO:0002503,GO:0002503,GO:0002842,GO:0002862,GO:0005200,GO:0005515,GO:0005615,GO:0005765,GO:0005765,GO:0005765,GO:0005882,GO:0005886,GO:0006955,GO:0006955,GO:0006955,GO:0006955,GO:0006959,GO:0007010,GO:0007165,GO:0007165,GO:0008544,GO:0009897,GO:0009986,GO:0012507,GO:0016020,GO:0016020,GO:0016020,GO:0016045,GO:0019886,GO:0019886,GO:0023026,GO:0023026,GO:0030225,GO:0030247,GO:0030658,GO:0030666,GO:0030669,GO:0031902,GO:0031902,GO:0032395,GO:0032395,GO:0032395,GO:0032588,GO:0032653,GO:0032673,GO:0032689,GO:0032831,GO:0033674,GO:0035774,GO:0042088,GO:0042130,GO:0042605,GO:0042605,GO:0042608,GO:0042609,GO:0042613,GO:0042613,GO:0042613,GO:0043123,GO:0043382,GO:0043410,GO:0045622,GO:0045657,GO:0045893,GO:0046598,GO:0050778,GO:0050852,GO:0050870,GO:0051262,GO:0070062,GO:0070374,GO:0098553,GO:2000516

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HLA-DRB1 hsa:3123 path:hsa04145 Phagosome - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05140 Leishmaniasis - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05152 Tuberculosis - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05164 Influenza A - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05310 Asthma - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05330 Allograft rejection - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
HLA-DRB1 hsa:3123 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HLA-DMA HLA-DRB1 21131964 23180781 physical association surface plasmon resonance InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 HLA-DRB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HLA-DRB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HLA-DRB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HLA-DRB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CIITA HLA-DRB1 10886240 trascriptional regulation,stimulation inferred by curator TFlink
ILF3 HLA-DRB1 7651394 trascriptional regulation,stimulation inferred by curator TFlink
RFX5 HLA-DRB1 11258423 18723135 trascriptional regulation,stimulation inferred by curator TFlink
RFXANK HLA-DRB1 11258423 trascriptional regulation,stimulation inferred by curator TFlink
RFXAP HLA-DRB1 11258423 18723135 trascriptional regulation,stimulation inferred by curator TFlink
VDR HLA-DRB1 19956544 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 HLA-DRB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 HLA-DRB1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000096022 HLA-DRB1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000544FF1 HLA-DRB1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRIM21 HLA-DRB1 25348397 N/A physical interaction ComPPI
HSPA8 HLA-DRB1 25348397 N/A physical interaction ComPPI
VCP HLA-DRB1 25348397 N/A physical interaction ComPPI
HSP90AB1 HLA-DRB1 25348397 N/A physical interaction ComPPI
INS HLA-DRB1 24234451 25348397 26437244 physical association x-ray crystallography ComPPI,IntAct
CD9 HLA-DRB1 23289620 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HSP90AA1 HLA-DRB1 25348397 N/A physical interaction ComPPI
HSPA1A HLA-DRB1 17357109 24234451 24428437 25348397 physical association solid phase assay ComPPI,IntAct
HLA-DRB3 HLA-DRB1 25348397 N/A physical interaction ComPPI
PKM HLA-DRB1 25348397 N/A physical interaction ComPPI
ATP1B1 HLA-DRB1 25348397 N/A physical interaction ComPPI
ANXA11 HLA-DRB1 25348397 N/A physical interaction ComPPI
ZDHHC17 HLA-DRB1 25348397 N/A physical interaction ComPPI
YWHAE HLA-DRB1 25348397 N/A physical interaction ComPPI
ITGA6 HLA-DRB1 25348397 N/A physical interaction ComPPI
MBP HLA-DRB1 21131964 23260142 24234451 25348397 association,physical association fluorescence polarization spectroscopy ComPPI,IntAct
MME HLA-DRB1 23289620 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MS4A1 HLA-DRB1 25348397 N/A physical interaction ComPPI
EIF2AK3 HLA-DRB1 25348397 N/A physical interaction ComPPI
SEMA4F HLA-DRB1 25348397 N/A physical interaction ComPPI
CNDP1 HLA-DRB1 25348397 N/A physical interaction ComPPI
HLA-DRB5 HLA-DRB1 25348397 N/A physical interaction ComPPI
HLA-DRB1 CTAG1A 11782380 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HLA-DRB1 HLA-DRA 11432818 11877480 14525934 21131964 23260142 24234451 25348397 26437244 7477400 9354468 association,physical association experimental interaction detection,fluorescence polarization spectroscopy,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
HLA-DRB1 HLA-DMA 21131964 23260142 24234451 25348397 association,physical association fluorescence polarization spectroscopy,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,IntAct
HLA-DRB1 HSP90AA2P 25348397 N/A physical interaction ComPPI
HLA-DRB1 MAGEA3 25348397 N/A physical interaction ComPPI
HLA-DRB1 HLA-DRB1 25348397 N/A physical interaction ComPPI
HLA-DRB1 PHOSPHO1 25348397 N/A physical interaction ComPPI
HLA-DRB1 OGN 25348397 N/A physical interaction ComPPI
HLA-DRB1 NAALADL2 25348397 N/A physical interaction ComPPI
HLA-DRB1 FNDC4 25348397 N/A physical interaction ComPPI
HLA-DRB1 EMC6 25348397 N/A physical interaction ComPPI
HLA-DRB1 CNNM1 25348397 N/A physical interaction ComPPI
HLA-DRB1 SQLE 25348397 N/A physical interaction ComPPI
HLA-DRB1 RNF149 25348397 N/A physical interaction ComPPI
HLA-DRB1 PDE3B 25348397 N/A physical interaction ComPPI
HLA-DRB1 KIAA0319L 25348397 N/A physical interaction ComPPI
HLA-DRB1 BTN2A2 25348397 N/A physical interaction ComPPI
HLA-DRB1 CTDNEP1 25348397 N/A physical interaction ComPPI
HLA-DRB1 BPNT2 25348397 N/A physical interaction ComPPI
HLA-DMB HLA-DRB1 21131964 23260142 24234451 25348397 association,physical association fluorescence polarization spectroscopy,x-ray crystallography ComPPI,IntAct
HLA-DRB1 TRAC 11877480 24234451 25348397 physical association x-ray crystallography ComPPI,IntAct
HLA-DRB1 TRBC1 11877480 24234451 25348397 physical association x-ray crystallography ComPPI,IntAct
CD74 HLA-DRB1 2391366 27898060 N/A N/A OmniPath
HLA-DRB1 CTSS 14966190 27898060 N/A N/A OmniPath
HLA-DRB1 CTSL 14966190 27898060 N/A N/A OmniPath
HLA-DRB1 LGMN 14966190 27898060 N/A N/A OmniPath
HLA-DRB1 CTSV 14966190 27898060 N/A N/A OmniPath
HLA-DRB1 CTSF 14966190 27898060 N/A N/A OmniPath

Visualization










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