GENE：IL17A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IL17A |
| FullNmae | interleukin 17A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5981 |
| EnsembleID | ENSG00000112115 |
| Uniprot | Q16552 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IL17A | immunogenic | 37275552 | To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IL17A | GO:0002225,GO:0002250,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0006915,GO:0006954,GO:0006955,GO:0007219,GO:0007267,GO:0008219,GO:0009611,GO:0009897,GO:0010467,GO:0030216,GO:0032731,GO:0032735,GO:0032739,GO:0032747,GO:0032755,GO:0032760,GO:0038173,GO:0042803,GO:0043616,GO:0045087,GO:0045672,GO:0045944,GO:0046982,GO:0050829,GO:0050830,GO:0050832,GO:0060729,GO:0071347,GO:0072537,GO:0097400,GO:0097530,GO:0106015,GO:1900017,GO:1903348,GO:2000340 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IL17A | hsa:3605 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| IL17A | hsa:3605 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| IL17A | hsa:3605 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| IL17A | hsa:3605 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| IL17A | hsa:3605 | path:hsa05321 | Inflammatory bowel disease - Homo sapiens (human) |
| IL17A | hsa:3605 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IL17RA | IL17A | 11058597 17911633 18684971 19838198 23180781 9367539 | physical association | fluorescence-activated cell sorting,surface plasmon resonance,competition binding,solid phase assay | InnateDB |
| IL17RC | IL17A | 17911633 18684971 19838198 23180781 | physical association | fluorescence-activated cell sorting,surface plasmon resonance,solid phase assay | InnateDB |
| IL17A | IL17RA | 19838198 23180781 | physical association | surface plasmon resonance | InnateDB |
| IL17A | IL17RC | 19838198 23180781 | physical association | surface plasmon resonance | InnateDB |
| BCL3 | IL17A | 23180781 25089799 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | IL17A | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | IL17A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | IL17A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | IL17A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC11 | IL17A | 21239696 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | IL17A | 21243522 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | IL17A | 21243522 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RORC | IL17A | 19578368 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | IL17A | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000338542 | IL17A | 25416803 26589478 | mrna cleavage,inhibition | quantitative reverse transcription pcr | TarBase |
| URS00004BCD9C | IL17A | 25416803 27596960 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TRAF6 | IL17A | 25348397 | N/A | physical interaction | ComPPI |
| IL17A | IL17RA | 14525934 25348397 9367539 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| IL17A | TRAF3IP2 | 25348397 | N/A | physical interaction | ComPPI |
| IL17A | DPH2 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| IL17A | ATP1A3 | 25348397 | N/A | physical interaction | ComPPI |
| IL17A | DPP8 | 25348397 | N/A | physical interaction | ComPPI |
| IL17A | LONP2 | 25348397 | N/A | physical interaction | ComPPI |
| IL17A | IL2 | 25348397 | N/A | physical interaction | ComPPI |
| IL17A | TXNDC15 | 25348397 | N/A | physical interaction | ComPPI |
| IL17A | A1BG | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| IL17A | KCNIP4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| IL17A | IL17A | 14525934 9518462 | N/A | experimental interaction detection | HPRD |
| IL17A | IL17RA | 11058597 17911633 18684971 19838198 27898060 9367539 | stimulant | N/A | OmniPath |
| IL17A | IL17RC | 17911633 18684971 19838198 27898060 | N/A | N/A | OmniPath |