Gene Information gene info

  1. Home

GENE：IL18

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL18
FullNmae interleukin 18
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5986
EnsembleID ENSG00000150782
Uniprot Q14116

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL18 pyroptosis 36918839 The pyroptosis-related genes BAX, IL18, and CYCS were significantly different between AD patients and normal controls. retulator signature
IL18 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
IL18 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL18 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL18 GO:0001525,GO:0005125,GO:0005125,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006954,GO:0007267,GO:0008283,GO:0010744,GO:0030101,GO:0030155,GO:0030431,GO:0032148,GO:0032722,GO:0032725,GO:0032729,GO:0032729,GO:0032736,GO:0032740,GO:0032819,GO:0034105,GO:0035655,GO:0038061,GO:0042088,GO:0042092,GO:0042104,GO:0042119,GO:0042267,GO:0042531,GO:0042632,GO:0045515,GO:0045630,GO:0045662,GO:0045944,GO:0048661,GO:0050729,GO:0050729,GO:0050830,GO:0051092,GO:0051142,GO:0051897,GO:0061436,GO:0070328,GO:0120162,GO:0150078,GO:1901224,GO:2000556

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL18 hsa:3606 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL18 hsa:3606 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL18 hsa:3606 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IL18 hsa:3606 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
IL18 hsa:3606 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
IL18 hsa:3606 path:hsa05131 Shigellosis - Homo sapiens (human)
IL18 hsa:3606 path:hsa05132 Salmonella infection - Homo sapiens (human)
IL18 hsa:3606 path:hsa05134 Legionellosis - Homo sapiens (human)
IL18 hsa:3606 path:hsa05135 Yersinia infection - Homo sapiens (human)
IL18 hsa:3606 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
IL18 hsa:3606 path:hsa05144 Malaria - Homo sapiens (human)
IL18 hsa:3606 path:hsa05152 Tuberculosis - Homo sapiens (human)
IL18 hsa:3606 path:hsa05164 Influenza A - Homo sapiens (human)
IL18 hsa:3606 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL18 hsa:3606 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
IL18 hsa:3606 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL18 IL18R1 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 IL18RAP 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IRAK4 IL18 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
MYD88 IL18 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 TGFBR2 10679398 11592085 14504095 14662834 15099563 15802534 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 SMAD2 10679398 11592085 14504095 14662834 15099563 15802534 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 SMAD3 10679398 11592085 14504095 14662834 15099563 15802534 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 CCR7 10679398 11592085 14504095 14662834 15099563 15802534 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 ICAM1 10679398 11592085 14504095 14662834 15099563 15802534 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL13 IL18 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
IL13RA1 IL18 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL4R IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
JAK1 IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
JAK2 IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
TYK2 IL18 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL4 IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL2RG IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
NFKBID IL18 15749903 16243976 16413922 17404308 17485448 23390297 26192618 interaction type N/A ACSN
IL18 IRAK1 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 TBX21 10679398 11592085 14504095 14662834 15099563 15802534 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18 HMGB1 10679398 10952726 11592085 11672593 12646658 12803886 14504095 14662834 15099563 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 26885855 27048821 27066895 27192565 9469432 interaction type N/A ACSN
CASP1 IL18 15326478 23180781 9121587 9334240 cleavage reaction,protein cleavage,physical association anti tag coimmunoprecipitation,protease assay InnateDB
CASP4 IL18 15326478 23180781 9121587 cleavage reaction,protein cleavage protease assay InnateDB
CASP5 IL18 23180781 9121587 cleavage reaction protease assay InnateDB
CASP3 IL18 23180781 9334240 cleavage reaction protease assay InnateDB
IL18BP IL18 10023777 10094485 10655506 11278524 11907126 12381835 23180781 physical association protein cross-linking with a bifunctional reagent,surface plasmon resonance,comigration in sds page InnateDB
IL18R1 IL18 12096920 23180781 9325300 physical association pull down,competition binding InnateDB
IL18 PRTN3 22270365 23180781 protein cleavage protease assay InnateDB
IL18 CASP1 22270365 23180781 protein cleavage protease assay InnateDB
IL18 IL18BP 18203261 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
AR IL18 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IL18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 IL18 11944905 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL18 10227974 15963597 17399992 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL18 10227974 15963597 17399992 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL18 14991611 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000134ADC IL18 19342689 rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000134ADC IL18 19342689 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000F4AC3 IL18 23710316 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000315338 IL18 24801815 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
WASHC3 IL18 25348397 N/A physical interaction ComPPI
CASP3 IL18 14525934 25348397 9334240 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP1 IL18 14525934 25348397 9334240 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASK IL18 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TDGF1 IL18 25348397 N/A physical interaction ComPPI
IL18 IL18BP 25348397 N/A physical interaction,in vitro,in vivo ComPPI
IL18 IL18R1 14525934 24234451 25261253 25348397 9325300 N/A experimental interaction detection,molecular sieving,x-ray crystallography,in vitro,in vivo ComPPI,HPRD,IntAct
IL18 IL18RAP 14525934 25348397 9792649 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL18 IL1RL2 14525934 25348397 9325300 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IL18 CASP4 14525934 15326478 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL18 SHMT2 25348397 N/A physical interaction ComPPI
IL18 TDGF1P3 25348397 N/A physical interaction ComPPI
IL18 CDK15 25348397 N/A physical interaction ComPPI
IL18 ZNF747 25348397 N/A physical interaction ComPPI
IL18 SERPINB4 25348397 N/A physical interaction ComPPI
IL18 A1BG 25348397 N/A physical interaction,biochemical ComPPI
IL18 ADIRF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP1 IL18 15326478 17039247 22270365 27898060 9121587 9334240 stimulant N/A OmniPath
IL18 CASP1 15326478 22270365 27898060 9121587 9334240 N/A N/A OmniPath
CASP4 IL18 15326478 27898060 9121587 N/A N/A OmniPath
CASP3 IL18 27898060 9334240 N/A N/A OmniPath
CASP5 IL18 17039247 27898060 9121587 stimulant N/A OmniPath
IL18 IL18R1 11046021 12096920 25261253 27898060 9325300 9792649 stimulant N/A OmniPath
PRTN3 IL18 22270365 27898060 N/A N/A OmniPath
IL18 IL18BP 10023777 10094485 10655506 11278524 11907126 12381835 18203261 27898060 N/A N/A OmniPath
IL18 IL1RAPL1 11046021 27898060 9325300 stimulant N/A OmniPath

Visualization










  Return