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GENE：IL18R1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL18R1
FullNmae interleukin 18 receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5988
EnsembleID ENSG00000115604
Uniprot Q13478

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL18R1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL18R1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL18R1 GO:0004908,GO:0005515,GO:0005886,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0030101,GO:0032729,GO:0032729,GO:0035655,GO:0035655,GO:0038023,GO:0038061,GO:0042007,GO:0042007,GO:0042008,GO:0042008,GO:0045063,GO:0045092,GO:0050135,GO:0051092,GO:0061809,GO:0120163,GO:1901224,GO:2000556

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL18R1 hsa:8809 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL18R1 hsa:8809 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL18R1 hsa:8809 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
IL18R1 hsa:8809 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL18 IL18R1 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18RAP IL18R1 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 association N/A ACSN
IRAK4 IL18R1 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
MYD88 IL18R1 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL18R1 IRAK1 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL15 IL18R1 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL21 IL18R1 12244150 16081783 16785506 24751819 26192618 interaction type N/A ACSN
IFNG IL18R1 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
IL18R1 IL18 12096920 23180781 9325300 physical association pull down,competition binding InnateDB
IL18R1 IL37 12096920 23180781 25654981 physical association pull down,solid phase assay InnateDB
EGR1 IL18R1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
TBX21 IL18R1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL18R1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
TICAM2 IL18R1 22685567 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 IL18R1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 IL18R1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 IL18R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
IL1RAP IL18R1 14525934 25348397 27898060 8626725 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CD48 IL18R1 14525934 15760905 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IL18 IL18R1 14525934 24234451 25261253 25348397 9325300 N/A experimental interaction detection,molecular sieving,x-ray crystallography,in vitro,in vivo ComPPI,HPRD,IntAct
IL18R1 IL37 12096920 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VAPB IL18R1 24234451 30021884 physical association cross-linking study IntAct
SPTBN1 IL18R1 24234451 30021884 physical association cross-linking study IntAct
TICAM2 IL18R1 22685567 27898060 N/A N/A OmniPath
IL18 IL18R1 11046021 12096920 25261253 27898060 9325300 9792649 stimulant N/A OmniPath
IL18R1 IL18RAP 27898060 9792649 N/A N/A OmniPath
IL18R1 IL1RAPL1 11046021 27898060 9325300 N/A N/A OmniPath
IL1RAPL1 IL18R1 11046021 27898060 9325300 N/A N/A OmniPath

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