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GENE：IL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL2
FullNmae interleukin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6001
EnsembleID ENSG00000109471
Uniprot P60568

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IL2 GO:0001933,GO:0002250,GO:0002366,GO:0002639,GO:0002903,GO:0005125,GO:0005134,GO:0005134,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006366,GO:0006955,GO:0007155,GO:0007204,GO:0007205,GO:0007267,GO:0008083,GO:0008284,GO:0019209,GO:0030101,GO:0030217,GO:0030246,GO:0030307,GO:0030890,GO:0031851,GO:0032729,GO:0032740,GO:0034105,GO:0038110,GO:0042104,GO:0042531,GO:0043066,GO:0043208,GO:0045471,GO:0045591,GO:0045944,GO:0046013,GO:0048304,GO:0050672,GO:0050728,GO:0050729,GO:0050798,GO:0060999,GO:0097192,GO:1900100,GO:1901327,GO:2000320,GO:2000561

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL2 hsa:3558 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL2 hsa:3558 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL2 hsa:3558 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL2 hsa:3558 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
IL2 hsa:3558 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL2 hsa:3558 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IL2 hsa:3558 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL2 hsa:3558 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
IL2 hsa:3558 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
IL2 hsa:3558 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
IL2 hsa:3558 path:hsa05135 Yersinia infection - Homo sapiens (human)
IL2 hsa:3558 path:hsa05142 Chagas disease - Homo sapiens (human)
IL2 hsa:3558 path:hsa05162 Measles - Homo sapiens (human)
IL2 hsa:3558 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
IL2 hsa:3558 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IL2 hsa:3558 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL2 hsa:3558 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
IL2 hsa:3558 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL2 hsa:3558 path:hsa05330 Allograft rejection - Homo sapiens (human)
IL2 hsa:3558 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL2 IL2RB 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26192618 26755705 2965306 6164929 7512720 7521688 8683106 9625766 interaction type N/A ACSN
IL2 IL2RG 10807786 10820393 10849428 11418623 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23180781 23331499 23650441 24829413 26192618 26755705 2965306 6164929 7512720 7521688 7681595 7829965 8683106 9625766 interaction type,stimulation,physical association anti tag coimmunoprecipitation,pull down ACSN,InnateDB,SignaLink
JAK1 IL2 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26192618 26755705 2965306 6164929 7512720 7521688 8683106 9625766 interaction type N/A ACSN
RELA IL2 10679398 12133954 12759422 14668329 15079071 15536066 17056544 17145890 17404308 17550372 19171876 20138012 21224476 23180781 23430059 26192618 8383323 8580069 9743347 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
BCL3 IL2 12907458 14668329 15079071 15465827 15536066 17145890 17404308 19171876 20138012 23430059 26192618 8383323 8580069 interaction type N/A ACSN
CD28 IL2 10426994 11907067 1313950 15197224 15536084 16713974 22437870 26192618 7523569 9359474 interaction type N/A ACSN
KLRG1 IL2 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTPN11 IL2 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
ADORA2A IL2 17371980 17909080 18758473 26192618 interaction type N/A ACSN
TIGIT IL2 22285893 22427644 25866972 26192618 26755705 26763253 27620276 28893624 interaction type N/A ACSN
PTPN6 IL2 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26192618 26667266 26755705 27474009 8976179 8986721 9751747 9765283 interaction type N/A ACSN
CD2 IL2 19398758 19494291 26192618 26794910 interaction type N/A ACSN
IL2 WASF2 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL2 SH2D1A 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL2 KIR2DL4 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL15 IL2 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
CD40LG IL2 11581322 15034038 17200410 17371980 23125331 26192618 8760829 interaction type N/A ACSN
CD247 IL2 10562324 11062502 11353765 11385609 12731048 15536084 20814939 21059766 23414611 26192618 8478617 9625766 9738502 interaction type N/A ACSN
IL2 STAT4 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL2 IKBKG 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL2 TBX21 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL2 IL12RB2 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL2 IL12RB1 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IL2 LTA 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
PML IL2 17928811 19218564 20452955 26192618 interaction type N/A ACSN
IL2 RELA 18045535 23180781 7623820 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL2 REL 1508203 23180781 7623820 physical association electrophoretic mobility supershift assay InnateDB
ATF4 IL2 23180781 9417115 physical association electrophoretic mobility supershift assay InnateDB
IL2 HMGA1 23180781 8934574 physical association electrophoretic mobility supershift assay InnateDB
IL2 XRCC5 17389650 23180781 physical association anti tag coimmunoprecipitation InnateDB
XRCC6 IL2 17389650 23180781 physical association anti tag coimmunoprecipitation InnateDB
ILF3 IL2 17389650 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2 CREM 15841182 20694009 23180781 9545284 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL2 IL2RA 12649439 15178252 1940342 23180781 3095922 6815536 8580082 8894436 8960125 physical association anti tag coimmunoprecipitation,protein cross-linking with a bifunctional reagent,isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,competition binding InnateDB
IL2 CREB1 11313407 15841182 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL2 MSN 11207255 23180781 physical association pull down InnateDB
FOS IL2 20557936 23180781 9590239 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL2 JUN 20557936 23180781 9065434 9590239 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
IL2 FOXK2 23180781 9065434 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
IL2RB IL2 15178252 1940342 23180781 3095922 3098894 8568232 physical association anti tag coimmunoprecipitation,protein cross-linking with a bifunctional reagent,isothermal titration calorimetry,competition binding InnateDB
IL2 RPS3 18045535 23180781 physical association anti tag coimmunoprecipitation InnateDB
A2M IL2 23180781 9780213 physical association comigration in non denaturing gel electrophoresis InnateDB
EP300 IL2 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2RG IL2 23180781 8568232 physical association protein cross-linking with a bifunctional reagent InnateDB
IL2 NFATC2 12560487 20557936 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
NFATC1 IL2 12560487 20557936 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IL2 IKZF3 20676092 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2 NFATC3 15980153 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL2 EGR1 12560487 23180781 physical association electrophoretic mobility shift assay InnateDB
IL2 EGR4 12560487 23180781 physical association electrophoretic mobility shift assay InnateDB
SP1 IL2 12560487 23180781 physical association electrophoretic mobility shift assay InnateDB
FOXP3 IL2 22806628 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2 FOXP3 23180781 23954131 physical association anti tag coimmunoprecipitation InnateDB
IL2 CTNNB1 23180781 23954131 physical association anti tag coimmunoprecipitation InnateDB
IL2 TCF7 23180781 23954131 physical association anti tag coimmunoprecipitation InnateDB
IL2 NFATC1 16498406 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2 POU2F1 16498406 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUNX1 IL2 22253733 23180781 physical association anti tag coimmunoprecipitation InnateDB
HDAC1 IL2 17056544 21976679 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREM IL2 17056544 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CREM IL2 12370343 12626549 15841182 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IL2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
JUN IL2 7642615 8468462 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
MYC IL2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NFAM1 IL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL2 11035116 11145913 12027419 15477007 18207244 18971253 19968887 7623820 7957556 8814256 8834450 8977179 9135552 9233628 9737979 trascriptional regulation,stimulation inferred by curator TFlink
TBP IL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL2 12560487 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BACH2 IL2 18769450 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 IL2 8814256 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 IL2 7876544 trascriptional regulation,stimulation inferred by curator TFlink
FOXK2 IL2 16624804 trascriptional regulation,stimulation inferred by curator TFlink
FOXP3 IL2 18324310 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 IL2 17056544 trascriptional regulation,stimulation inferred by curator TFlink
ILF2 IL2 9065434 trascriptional regulation,stimulation inferred by curator TFlink
ILF3 IL2 18097023 trascriptional regulation,stimulation inferred by curator TFlink
KAT5 IL2 11145913 trascriptional regulation,stimulation inferred by curator TFlink
KLF2 IL2 16116194 trascriptional regulation,stimulation inferred by curator TFlink
NFATC1 IL2 12560487 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 IL2 11781715 9135552 trascriptional regulation,stimulation inferred by curator TFlink
REL IL2 8920856 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL2 11035116 11145913 12027419 15477007 18207244 19968887 7623820 8814256 8977179 9135552 9233628 9737979 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IL2 17466384 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 IL2 15713622 trascriptional regulation,stimulation inferred by curator TFlink
SP1 IL2 8814256 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 IL2 8814256 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 IL2 18550668 trascriptional regulation,stimulation inferred by curator TFlink
TOB1 IL2 11694881 trascriptional regulation,stimulation inferred by curator TFlink
VDR IL2 7565732 trascriptional regulation,stimulation inferred by curator TFlink
ZFP36 IL2 15634918 trascriptional regulation,stimulation inferred by curator TFlink
ZNF823 IL2 15634918 trascriptional regulation,stimulation inferred by curator TFlink
AR IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
EGR4 IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS2 IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
FOS IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARG IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 IL2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000018C928 IL2 21112091 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr miRSponge
URS000018C928 IL2 21112091 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase
URS00005651EE IL2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000338542 IL2 22785227 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS0000237CBD IL2 25416803 27145859 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000F6E49 IL2 25416803 26580839 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
SHC1 IL2 10662798 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IL2RB IL2 11035066 14525934 16477002 22446627 24234451 25348397 8049354 physical association biophysical,experimental interaction detection,isothermal titration calorimetry,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
NGFR IL2 1316918 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
IL2RG IL2 10662798 14525934 25348397 8049354 N/A biophysical,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL17A IL2 25348397 N/A physical interaction ComPPI
IL2RA IL2 14525934 16477002 17032757 1993646 24234451 25348397 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vivo,solid phase assay ComPPI,HPRD,IntAct
IFNA1 IL2 14525934 25348397 3262520 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD53 IL2 14525934 25348397 7963560 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL2 FOXK2 14525934 25348397 27898060 9065434 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
IL2 IL2 12582206 14525934 N/A experimental interaction detection HPRD
MSN IL2 11207255 27898060 N/A N/A OmniPath
IL2 IL2RG 10662798 11418623 16477002 27898060 7681595 7829965 8006584 8049354 8568232 inhibition,stimulant N/A OmniPath
IL2 IL2RB 11035066 15178252 15265897 15933202 16477002 1940342 22446627 27898060 3095922 3098894 8006584 8049354 8568232 stimulant N/A OmniPath
IL2 IL2RA 12649439 15178252 15265897 15933202 16477002 17032757 1940342 1993646 27898060 3095922 6815536 8580082 8894436 8960125 stimulant N/A OmniPath

Visualization










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