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GENE：IL2RA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL2RA
FullNmae interleukin 2 receptor subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6008
EnsembleID ENSG00000134460
Uniprot P01589

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL2RA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL2RA GO:0002437,GO:0002664,GO:0004911,GO:0004911,GO:0005515,GO:0005886,GO:0005886,GO:0005893,GO:0006915,GO:0006924,GO:0006954,GO:0006955,GO:0007166,GO:0007219,GO:0009897,GO:0019976,GO:0038110,GO:0042104,GO:0042130,GO:0045582,GO:0046013,GO:0050728,GO:0050798,GO:2000561

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL2RA hsa:3559 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL2RA hsa:3559 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL2RA hsa:3559 path:hsa04144 Endocytosis - Homo sapiens (human)
IL2RA hsa:3559 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL2RA hsa:3559 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL2RA hsa:3559 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL2RA hsa:3559 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IL2RA hsa:3559 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL2RA hsa:3559 path:hsa05162 Measles - Homo sapiens (human)
IL2RA hsa:3559 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
IL2RA hsa:3559 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELF1 IL2RA 23180781 7862168 physical association electrophoretic mobility supershift assay InnateDB
IL2RA HMGA1 23180781 7862168 physical association electrophoretic mobility supershift assay InnateDB
IL2RA REL 1508203 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL2RA SNTA1 15123239 23180781 physical association peptide array InnateDB
IL2 IL2RA 12649439 15178252 1940342 23180781 3095922 6815536 8580082 8894436 8960125 physical association anti tag coimmunoprecipitation,protein cross-linking with a bifunctional reagent,isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,competition binding InnateDB
IL2RA STAT5A 23180781 8896456 physical association electrophoretic mobility supershift assay InnateDB
STAT5B IL2RA 23180781 24497979 8896456 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
EIF1 IL2RA 23180781 8896456 physical association electrophoretic mobility supershift assay InnateDB
IL2RA GATA1 23180781 8896456 physical association electrophoretic mobility supershift assay InnateDB
IL2RA RELA 18045535 21399639 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 IL2RA 12244150 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL2RA STAT4 12244150 23180781 physical association electrophoretic mobility shift assay InnateDB
IL2RB IL2RA 15178252 1545122 23180781 8568232 physical association anti tag coimmunoprecipitation,protein cross-linking with a bifunctional reagent,isothermal titration calorimetry InnateDB
TCF4 IL2RA 16126178 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2RG IL2RA 23180781 8568232 physical association protein cross-linking with a bifunctional reagent InnateDB
TBX21 IL2RA 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL2RA 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 IL2RA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IL2RA 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 IL2RA 20554955 21036387 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 IL2RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL2RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL2RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL2RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IL2RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MSC IL2RA 19561533 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL2RA 11781710 9135552 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 IL2RA 9135552 trascriptional regulation,stimulation inferred by curator TFlink
REL IL2RA 1508203 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL2RA 11781710 9135552 trascriptional regulation,stimulation inferred by curator TFlink
RXRA IL2RA 12149223 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 IL2RA 15713622 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IL2RA 10068671 12244150 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 IL2RA 10068671 11368440 24159173 trascriptional regulation,stimulation inferred by curator TFlink
STAT4 IL2RA 10068671 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL2RA N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A IL2RA N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B IL2RA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048D44E IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000321A1A IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AF45F IL2RA 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA IL2RA 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CD4 IL2RA 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
HGS IL2RA 25348397 N/A physical interaction ComPPI
STAT5B IL2RA 10602027 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL2RB IL2RA 11886175 14525934 25348397 N/A biophysical,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SNTA1 IL2RA 25348397 N/A physical interaction ComPPI
NFKB1 IL2RA 14525934 2497520 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STAT3 IL2RA 10602027 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL2RA IL2 14525934 16477002 17032757 1993646 24234451 25348397 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vivo,solid phase assay ComPPI,HPRD,IntAct
IL2RA ICAM1 14525934 1976256 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PASK IL2RA 21418524 24234451 25348397 phosphorylation reaction peptide array ComPPI,IntAct
IL2RA IL2RA 11886175 14525934 N/A experimental interaction detection HPRD
SRC IL2RA 27898060 2941417 N/A N/A OmniPath
PRKCA IL2RA 2303462 27898060 2941417 N/A N/A OmniPath
SNTA1 IL2RA 15123239 27898060 N/A N/A OmniPath
IL15 IL2RA 27898060 8734356 N/A N/A OmniPath
IL2 IL2RA 12649439 15178252 15265897 15933202 16477002 17032757 1940342 1993646 27898060 3095922 6815536 8580082 8894436 8960125 stimulant N/A OmniPath
IL2RG IL2RA 15265897 15933202 27898060 8568232 N/A N/A OmniPath
IL2RA IL2RB 11886175 15178252 15265897 1545122 15933202 27898060 8006584 8568232 N/A N/A OmniPath
IL2RB IL2RA 11886175 15178252 15265897 1545122 15933202 27898060 8006584 8568232 stimulant N/A OmniPath

Visualization










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