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GENE：IL4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL4
FullNmae interleukin 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6014
EnsembleID ENSG00000113520
Uniprot P05112

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL4 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
IL4 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
IL4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL4 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
IL4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IL4 GO:0000122,GO:0001774,GO:0002227,GO:0002230,GO:0002674,GO:0002677,GO:0005125,GO:0005125,GO:0005136,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0006955,GO:0008083,GO:0008203,GO:0008284,GO:0008284,GO:0010628,GO:0010628,GO:0010633,GO:0010633,GO:0016239,GO:0016239,GO:0030183,GO:0030335,GO:0030890,GO:0031296,GO:0032720,GO:0032733,GO:0032733,GO:0032736,GO:0032736,GO:0035771,GO:0042092,GO:0042102,GO:0042110,GO:0042116,GO:0042325,GO:0042531,GO:0042531,GO:0042976,GO:0042976,GO:0043011,GO:0043011,GO:0043031,GO:0043066,GO:0043306,GO:0045064,GO:0045191,GO:0045348,GO:0045348,GO:0045582,GO:0045582,GO:0045671,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0048260,GO:0048260,GO:0048295,GO:0048295,GO:0048304,GO:0048304,GO:0050728,GO:0050776,GO:0071677,GO:0097028,GO:0097192,GO:0120162,GO:0150076,GO:0150079,GO:1900223,GO:1900223,GO:1901741,GO:1901857,GO:1903660,GO:1903660,GO:1903845,GO:2000320,GO:2000352,GO:2000352,GO:2000424,GO:2000553,GO:2001171,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL4 hsa:3565 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL4 hsa:3565 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL4 hsa:3565 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL4 hsa:3565 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL4 hsa:3565 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
IL4 hsa:3565 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IL4 hsa:3565 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL4 hsa:3565 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
IL4 hsa:3565 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
IL4 hsa:3565 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
IL4 hsa:3565 path:hsa05140 Leishmaniasis - Homo sapiens (human)
IL4 hsa:3565 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL4 hsa:3565 path:hsa05310 Asthma - Homo sapiens (human)
IL4 hsa:3565 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
IL4 hsa:3565 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL4 hsa:3565 path:hsa05330 Allograft rejection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL2RG IL4 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 8266078 9834059 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL4 IL4R 10219247 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 21889455 23124025 23180781 23331499 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type,stimulation,physical association x-ray crystallography ACSN,InnateDB,SignaLink
JAK1 IL4 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
JAK2 IL4 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL4 IL13RA1 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL4 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL4 STAT3 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21398617 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL4 IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL4 STAT6 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL4 MAF 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
IL4 IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL4 IL13 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
IL4 SOCS1 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
IL4 IFNG 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
IL4 HIF1A 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
IL4 CSF2RA 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
IL4 CSF1 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
IRF1 IL4 12479817 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL4 IRF2 12479817 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
A2M IL4 17725582 23180781 physical association comigration in non denaturing gel electrophoresis InnateDB
IL4R IL4 2278997 2307934 23180781 8266078 8639787 physical association anti tag coimmunoprecipitation,protein cross-linking with a bifunctional reagent,saturation binding InnateDB
IL4 IRF4 12374808 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL4 RELA 19915002 21989417 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 EGR1 19915002 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 CEBPB 19915002 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR3 IL4 19915002 23180781 physical association electrophoretic mobility supershift assay InnateDB
NFATC1 IL4 19915002 21398617 21989417 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
EP300 IL4 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 CREM 23180781 9545284 physical association electrophoretic mobility supershift assay InnateDB
CEBPG IL4 23180781 7665092 physical association electrophoretic mobility shift assay InnateDB
IL4 GATA3 21849680 21989417 22039304 22226971 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 MYB 22039304 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 NFATC2 22226971 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 JUN 21989417 23180781 physical association anti tag coimmunoprecipitation InnateDB
YY1 IL4 21989417 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK3 IL4 21989417 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK1 IL4 21989417 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 CYP2E1 15345327 23180781 physical association electrophoretic mobility shift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR IL4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IL4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 IL4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IL4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IL4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NFAM1 IL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 IL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB IL4 15048722 7594540 trascriptional regulation,stimulation inferred by curator TFlink
CIITA IL4 10946277 17645498 trascriptional regulation,stimulation inferred by curator TFlink
CREBBP IL4 10946277 trascriptional regulation,stimulation inferred by curator TFlink
GATA3 IL4 12876556 16498264 22226971 trascriptional regulation,stimulation inferred by curator TFlink
IRF2 IL4 7930616 trascriptional regulation,stimulation inferred by curator TFlink
JUNB IL4 21799768 trascriptional regulation,stimulation inferred by curator TFlink
MAF IL4 11956291 16498264 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL4 12516545 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 IL4 11781715 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL4 12516545 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 IL4 21799768 trascriptional regulation,stimulation inferred by curator TFlink
SPIC IL4 16647686 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 IL4 12082548 12605697 12776189 14993689 16647686 19419769 20214667 20225206 trascriptional regulation,stimulation inferred by curator TFlink
TBX21 IL4 17541280 18504404 19348920 22521571 trascriptional regulation,stimulation inferred by curator TFlink
YY1 IL4 11687571 trascriptional regulation,stimulation inferred by curator TFlink
CEBPG IL4 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETV4 IL4 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 IL4 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A IL4 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 IL4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 IL4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000055BBE5 IL4 25416803 27895317 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000007FBA IL4 25416803 27895317 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000F6E49 IL4 25416803 26580839 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
IL4R IL4 25361965 interaction type N/A PTMCode2
IL4 IL4R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
IL13RA1 IL4 18243101 24234451 25348397 physical association isothermal titration calorimetry,molecular sieving,x-ray crystallography ComPPI,IntAct
IL2RG IL4 14525934 18243101 24234451 25348397 8266078 association anti bait coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,in vivo ComPPI,HPRD,IntAct
A2M IL4 25348397 N/A physical interaction ComPPI
IL4R IL4 10219247 11786020 14525934 18243101 23597562 24234451 25348397 8266078 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cross-linking study,experimental interaction detection,isothermal titration calorimetry,scintillation proximity assay,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CD53 IL4 14525934 25348397 7963560 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL13RA2 IL4 14525934 25348397 27898060 9130652 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
IL4 IL4R 10219247 11786020 11815609 12704343 17312100 18243101 18852293 21889455 2278997 2307934 23597562 27898060 7721786 7918378 8266078 8639787 9874253 stimulant N/A OmniPath
IL4 IL2RG 11418623 27898060 8266078 stimulant N/A OmniPath
A2M IL4 17725582 27898060 N/A N/A OmniPath
IL4 IL13RA1 10641437 12704343 18243101 27898060 stimulant N/A OmniPath

Visualization










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