Gene Information gene info

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GENE：IL5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL5
FullNmae interleukin 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6016
EnsembleID ENSG00000113525
Uniprot P05113

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL5 GO:0002639,GO:0005125,GO:0005137,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0006954,GO:0006955,GO:0008083,GO:0030890,GO:0038043,GO:0045645,GO:0045893,GO:0046427,GO:0050731,GO:0071803

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL5 hsa:3567 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL5 hsa:3567 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL5 hsa:3567 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL5 hsa:3567 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
IL5 hsa:3567 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IL5 hsa:3567 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
IL5 hsa:3567 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
IL5 hsa:3567 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
IL5 hsa:3567 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL5 hsa:3567 path:hsa05310 Asthma - Homo sapiens (human)
IL5 hsa:3567 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
IL5 hsa:3567 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL5 hsa:3567 path:hsa05330 Allograft rejection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL5 STAT5A 15735688 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL5 IL5 23180781 2361960 8483502 disulfide bond x-ray crystallography,reverse phase chromatography InnateDB
IL5RA IL5 1732409 23180781 7721873 physical association cosedimentation in solution,protein cross-linking with a bifunctional reagent,isothermal titration calorimetry InnateDB
CSF2RB IL5 1495999 23180781 physical association protein cross-linking with a bifunctional reagent InnateDB
IL5 GATA3 21849680 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL5 NR3C1 18028994 23180781 physical association affinity chromatography technology InnateDB
IL5 STAT3 21398617 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFATC1 IL5 10582349 21398617 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
POU2F1 IL5 12354764 23180781 physical association electrophoretic mobility supershift assay InnateDB
POU2F2 IL5 12354764 23180781 physical association electrophoretic mobility supershift assay InnateDB
JUND IL5 12354764 23180781 physical association electrophoretic mobility supershift assay InnateDB
ETS1 IL5 10212281 23180781 physical association electrophoretic mobility shift assay InnateDB
IL5 IL5RA 22528658 23331499 8567620 phosphorylation reaction,stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
GATA4 IL5 7791790 9209438 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 IL5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NFAM1 IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA3 IL5 10212281 16498264 17270283 18971253 20522714 trascriptional regulation,stimulation inferred by curator TFlink
JUN IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TBP IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL5 10453008 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB IL5 10453008 trascriptional regulation,stimulation inferred by curator TFlink
EP300 IL5 16922677 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 IL5 10212281 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 IL5 10212281 19487701 trascriptional regulation,stimulation inferred by curator TFlink
FOSL2 IL5 10491186 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 IL5 16922677 trascriptional regulation,stimulation inferred by curator TFlink
JUND IL5 10491186 trascriptional regulation,stimulation inferred by curator TFlink
MAF IL5 16498264 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 IL5 10491186 trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 IL5 10491186 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 IL5 20522714 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL5 19487701 trascriptional regulation,stimulation inferred by curator TFlink
YY1 IL5 10518827 17270283 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 IL5 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000031602A IL5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000411752 IL5 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001067D1 IL5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 IL5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C IL5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC IL5 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IL5 CSF2RB 25361965 interaction type N/A PTMCode2
CSF2RB IL5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CSF2RB IL5 1495999 24234451 25348397 physical association cross-linking study,experimental interaction detection,physical interaction,biochemical,saturation binding ComPPI,IntAct
IL5 IL5RA 10880230 14525934 1495999 1732409 24234451 25348397 7721873 physical association cross-linking study,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,saturation binding,surface plasmon resonance array ComPPI,HPRD,IntAct
IL5 IL5 14525934 8483502 N/A experimental interaction detection HPRD
IL5 IL5RA 10880230 1495999 1732409 22153509 27898060 7721873 7957082 8567620 stimulant N/A OmniPath
IL5 CSF2RB 1495999 27898060 7957082 stimulant N/A OmniPath

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