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GENE：IL5RA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL5RA
FullNmae interleukin 5 receptor subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6017
EnsembleID ENSG00000091181
Uniprot Q01344

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL5RA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL5RA GO:0002437,GO:0004896,GO:0004914,GO:0005515,GO:0005615,GO:0005886,GO:0005886,GO:0007165,GO:0009897,GO:0016020,GO:0019221,GO:0019955,GO:0032674,GO:0038043,GO:0043235,GO:0070665

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL5RA hsa:3568 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL5RA hsa:3568 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL5RA hsa:3568 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL5RA hsa:3568 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL5RA IL5 1732409 23180781 7721873 physical association cosedimentation in solution,protein cross-linking with a bifunctional reagent,isothermal titration calorimetry InnateDB
CSF2RB IL5RA 1495999 23180781 physical association protein cross-linking with a bifunctional reagent InnateDB
IL5 IL5RA 22528658 23331499 8567620 phosphorylation reaction,stimulation N/A SignaLink,SignaLink
IL5RA JAK2 15795318 23331499 9516124 stimulation N/A SignaLink
IL5RA STAT5A 10582086 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 IL5RA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 IL5RA 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 IL5RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IL5RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL5RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 IL5RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL5RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 IL5RA 9742933 trascriptional regulation,stimulation inferred by curator TFlink
CREM IL5RA 9742933 trascriptional regulation,stimulation inferred by curator TFlink
JUN IL5RA 9742933 trascriptional regulation,stimulation inferred by curator TFlink
RFX1 IL5RA 10330134 10706293 trascriptional regulation,stimulation inferred by curator TFlink
RFX2 IL5RA 10330134 10706293 trascriptional regulation,stimulation inferred by curator TFlink
RFX3 IL5RA 10330134 10706293 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L1 IL5RA 19231596 trascriptional regulation,stimulation inferred by curator TFlink
TCF3 IL5RA 19231596 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000001EB3 IL5RA 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A IL5RA 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D IL5RA 22012620 23824327 24906430 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006372A IL5RA 22012620 23824327 24906430 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000085F64 IL5RA 22012620 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000076B539 IL5RA 22012620 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UNC119 IL5RA 12496276 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
GRB2 IL5RA 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
JAK1 IL5RA 14525934 24234451 25348397 9516124 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
SDCBP IL5RA 11498591 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
JAK2 IL5RA 14525934 24234451 25348397 9516124 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
CSF2RB IL5RA 14525934 1495999 24234451 25348397 9516124 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,saturation binding ComPPI,HPRD,IntAct
IL5 IL5RA 10880230 14525934 1495999 1732409 24234451 25348397 7721873 physical association cross-linking study,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,saturation binding,surface plasmon resonance array ComPPI,HPRD,IntAct
IL5RA STAT5A 10582086 27898060 stimulant N/A OmniPath
IL5RA JAK2 15795318 17312100 27898060 7602114 9516124 stimulant N/A OmniPath
IL5RA CSF2RB 1495999 27898060 9516124 N/A N/A OmniPath
IL5 IL5RA 10880230 1495999 1732409 22153509 27898060 7721873 7957082 8567620 stimulant N/A OmniPath

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