GENE：ISG20
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ISG20 |
| FullNmae | interferon stimulated exonuclease gene 20 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6130 |
| EnsembleID | ENSG00000172183 |
| Uniprot | Q96AZ6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ISG20 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ISG20 | GO:0000175,GO:0000932,GO:0004527,GO:0004527,GO:0005634,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006308,GO:0006364,GO:0006401,GO:0006401,GO:0008310,GO:0008859,GO:0009615,GO:0015030,GO:0016605,GO:0030619,GO:0030620,GO:0034511,GO:0045071,GO:0045071,GO:0045087,GO:0046872,GO:0051607,GO:0051607 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ISG20 | RELA | 15064705 23180781 | physical association | affinity chromatography technology | InnateDB |
| ISG20 | NFKB1 | 15064705 23180781 | physical association | affinity chromatography technology | InnateDB |
| ISG20 | IRF1 | 15064705 23180781 | physical association | affinity chromatography technology | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | ISG20 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | ISG20 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ISG20 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ISG20 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | ISG20 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | ISG20 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | ISG20 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ISG20 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | ISG20 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ISG20 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CEBPA | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ISG20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | ISG20 | 10871365 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | ISG20 | 10871365 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | ISG20 | 10871365 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DDIT4L | ISG20 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SRC | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| GNAQ | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRG | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| EPB41L1 | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| NCAM1 | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK1G3 | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| GNAZ | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| EFR3A | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| EEPD1 | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| ERICH5 | ISG20 | 25348397 | N/A | physical interaction | ComPPI |
| IRF1 | ISG20 | 15064705 27898060 | stimulant | N/A | OmniPath |
| NFKB1 | ISG20 | 15064705 27898060 | N/A | N/A | OmniPath |
| RELA | ISG20 | 15064705 27898060 | N/A | N/A | OmniPath |