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GENE：ITGA2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGA2B
FullNmae integrin subunit alpha 2b
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6138
EnsembleID ENSG00000005961
Uniprot P08514

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGA2B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITGA2B GO:0001525,GO:0002687,GO:0005178,GO:0005515,GO:0005886,GO:0005886,GO:0005925,GO:0007160,GO:0007229,GO:0007229,GO:0008305,GO:0009897,GO:0009986,GO:0031092,GO:0033627,GO:0042802,GO:0046872,GO:0050840,GO:0060090,GO:0070051,GO:0070062,GO:0072562,GO:0098609

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGA2B hsa:3674 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa04510 Focal adhesion - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa04611 Platelet activation - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
ITGA2B hsa:3674 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL7R ITGA2B 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT6 ITGA2B 20652946 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GRB2 ITGA2B 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
GATA1 ITGA2B 19941826 8408012 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ITGA2B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ITGA2B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ITGA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITGA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITGA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITGA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITGA2B 18971253 9305885 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITGA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 ITGA2B 15466856 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ITGA2B 12576332 17725493 18316480 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 ITGA2B 20652946 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 ITGA2B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
VWF ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B VWF 25361965 interaction type N/A PTMCode2
ITGB3 ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B ITGB3 25361965 interaction type N/A PTMCode2
ITGA2B COL1A2 25361965 interaction type N/A PTMCode2
COL1A2 ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B FGA 25361965 interaction type N/A PTMCode2
FGA ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B RNF181 25361965 interaction type N/A PTMCode2
RNF181 ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B CD36 25361965 interaction type N/A PTMCode2
CD36 ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B CIB1 25361965 interaction type N/A PTMCode2
CIB1 ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B GRB2 25361965 interaction type N/A PTMCode2
GRB2 ITGA2B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
COL1A2 ITGA2B 11359786 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CLNS1A ITGA2B 14525934 15075326 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD36 ITGA2B 11238109 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRB2 ITGA2B 11964172 14525934 25348397 8631894 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLNA ITGA2B 25348397 N/A nuclear magnetic resonance,physical interaction,surface plasmon resonance array ComPPI
PRKACA ITGA2B 25348397 N/A physical interaction ComPPI
CIB1 ITGA2B 10358085 14525934 20034469 25348397 27898060 9030514 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
F2 ITGA2B 11487023 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
ITGB3 ITGA2B 11606749 1429573 14525934 14681217 15067009 15379538 19279667 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,nuclear magnetic resonance,pull down,x-ray crystallography,physical interaction,lex-a dimerization assay,in vitro,in vivo,tandem affinity purification,surface plasmon resonance array ComPPI,HPRD,IntAct
TLN1 ITGA2B 14525934 16546176 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGA2B VWF 14525934 1737795 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGA2B CALR 14525934 14985176 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ITGA2B AUP1 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
ITGA2B COL2A1 10772239 14525934 25348397 7520045 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGA2B FGA 11460491 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGA2B RNF181 25348397 N/A physical interaction ComPPI
ITGA2B CAMK2A 25348397 N/A physical interaction ComPPI
ITGA2B FBXO6 25348397 N/A physical interaction ComPPI
ITGA2B PLA2G4A 25348397 N/A physical interaction ComPPI
ITGA2B FN1 25348397 N/A physical interaction ComPPI
ITGA2B FGG 25348397 N/A physical interaction ComPPI
ITGA2B ITGA2B 11606749 14525934 14681217 15067009 24234451 physical association cosedimentation in solution,experimental interaction detection,lex-a dimerization assay,tox-r dimerization assay,comigration in non denaturing gel electrophoresis HPRD,IntAct
ITGA2B PPP1CA 15205468 20034469 27898060 N/A N/A OmniPath
THBS1 ITGA2B 2478219 27898060 stimulant N/A OmniPath
FN1 ITGA2B 27898060 8663002 stimulant N/A OmniPath
IL7R ITGA2B 20167604 27898060 N/A N/A OmniPath
FGG ITGA2B 2018974 27898060 N/A N/A OmniPath
ITGB3 ITGA2B 10358085 11606749 1429573 14681217 15067009 15379538 19279667 19805198 22178926 25849143 27898060 7531639 8663002 N/A N/A OmniPath
FGB ITGA2B 2018974 27898060 N/A N/A OmniPath

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