Gene Information gene info

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GENE：ITK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITK
FullNmae IL2 inducible T cell kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6171
EnsembleID ENSG00000113263
Uniprot Q08881

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITK immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITK GO:0001819,GO:0001865,GO:0002250,GO:0002250,GO:0004715,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0006968,GO:0007165,GO:0007202,GO:0016310,GO:0035556,GO:0042110,GO:0046629,GO:0046872,GO:0050852,GO:0050852,GO:0050853

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITK hsa:3702 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
ITK hsa:3702 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
ITK hsa:3702 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CD4 ITK 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
LCK ITK 10652356 12731048 12740575 15771581 17544292 19132916 19290918 20814939 21127503 22513334 23109003 23620508 26192618 3263576 8478617 8986721 9312162 9438848 9738502 9751747 interaction type,chemical activation reaction N/A ACSN,SignaLink
ITK LAT 11406363 12186560 15661896 25137453 26192618 interaction type N/A ACSN
ITK PLCG1 10586033 11406363 11709089 12163161 12186560 12941616 15661896 23109003 23331499 25137453 26192618 interaction type,stimulation,chemical activation reaction N/A ACSN,SignaLink,SignaLink
ITK GRB2 11406363 12186560 15661896 25137453 26192618 interaction type N/A ACSN
ITK GRAP 11406363 12186560 15661896 25137453 26192618 interaction type N/A ACSN
ITK LCP2 15388330 23180781 physical association gst pull down InnateDB
EP300 ITK 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG ITK 20098747 23180781 physical association protein array InnateDB
ITK VAV3 12186560 23109003 chemical activation reaction N/A SignaLink
ITK VAV1 12186560 23109003 chemical activation reaction N/A SignaLink
CD28 ITK 15771581 19132916 23109003 9312162 chemical activation reaction N/A SignaLink
ZAP70 ITK 11709089 15084594 23109003 chemical activation reaction N/A SignaLink
LCP2 ITK 11709089 15084594 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BLNK ITK 20005715 interaction type N/A PSP
GRB2 ITK 20005715 interaction type N/A PSP
LAT ITK 10506192 12186560 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
LCP2 ITK 10556826 10636929 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
SH2D2A ITK 20005715 interaction type N/A PSP
SOCS1 ITK 20005715 interaction type N/A PSP
GRB2 ITK 10636929 20005715 21071413 8985255 N/A N/A SignaLink
SOCS1 ITK 10022833 10022833 18988627 20005715 20005715 21071413 N/A N/A SignaLink
BLNK ITK 10556826 18988627 20005715 20005715 N/A N/A SignaLink
SH2D2A ITK 10587356 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 ITK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ITK 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ITK 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITK 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 ITK 22785227 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000004BACE ITK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 ITK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F ITK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 ITK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D ITK 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TEC ITK 22135298 phosphorylation N/A PhosphoSite
LCK ITK 22135298 phosphorylation N/A PhosphoSite
ITK BTK 22135298 phosphorylation N/A PhosphoSite
ITK ITK 22135298 phosphorylation N/A PhosphoSite
ITK DEF6 22135298 phosphorylation N/A PhosphoSite
ITK PLCG1 22135298 phosphorylation N/A PhosphoSite
ITK BMX 22135298 phosphorylation N/A PhosphoSite
ITK SIGLEC10 22135298 phosphorylation N/A PhosphoSite
ITK HAVCR2 22135298 phosphorylation N/A PhosphoSite
ITK LCP2 22135298 phosphorylation N/A PhosphoSite
ITK TEC 22135298 phosphorylation N/A PhosphoSite
BTK ITK 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
KPNA2 ITK 11581171 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HNRNPK ITK 14525934 25348397 8810341 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LCP2 ITK 10556826 10636929 14525934 17420479 21725281 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
LAT ITK 10506192 12186560 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
WAS ITK 14525934 24234451 25348397 8810341 8892607 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD4 ITK 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSP90AB1 ITK 22939624 24234451 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
ERBB2 ITK 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
CBL ITK 14525934 25348397 8810341 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BTK ITK 11598012 12445832 12573241 14525934 25348397 8629002 8630736 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SOCS1 ITK 10022833 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BLNK ITK 10556826 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC ITK 25348397 N/A physical interaction ComPPI
DOK1 ITK 25348397 N/A physical interaction ComPPI
LCK ITK 14525934 15144186 25348397 9312162 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PLCG2 ITK 25348397 N/A in vitro ComPPI
CD2 ITK 25348397 N/A physical interaction ComPPI
KHDRBS1 ITK 14525934 25348397 8810341 8985255 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRB2 ITK 10636929 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITK CD28 10586033 14525934 15144186 25348397 8992971 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITK PPIA 11830645 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ITK FYN 14525934 25348397 8810341 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITK PLCG1 10586033 12163161 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ITK IKBKG 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
ITK FASLG 19807924 24234451 25348397 physical association phage display,pull down,physical interaction ComPPI,IntAct
ITK IBTK 25348397 N/A physical interaction ComPPI
ITK FGFR1 25348397 N/A physical interaction ComPPI
ITK HSP90AA1 25348397 N/A physical interaction ComPPI
ITK HSP90AA2P 25348397 N/A physical interaction ComPPI
ITK ERBB3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
ITK SPRR2A 18155796 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
ITK FUS 25348397 N/A physical interaction ComPPI
ITK EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
ITK NSUN6 25348397 N/A physical interaction ComPPI
ITK SMURF1 25348397 N/A physical interaction ComPPI
ITK DYNC1I2 25348397 N/A physical interaction ComPPI
ITK GAPDHS 25348397 N/A physical interaction ComPPI
ITK CDC37 25348397 N/A physical interaction ComPPI
ITK G3BP1 15743820 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ITK ABI1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
ITK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GAB1 ITK 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BMX ITK 12573241 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITK ITK 14525934 17192257 7567982 N/A experimental interaction detection HPRD
SH2D2A ITK 10587356 14525934 N/A two hybrid HPRD
ITK TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
AHNAK ITK 24234451 30021884 physical association cross-linking study IntAct
ITK PLCG1 10586033 11564877 1216316 12163161 15215251 15951569 17389395 19534553 19690332 20519342 27898060 8657103 stimulant N/A OmniPath
LCK ITK 12842872 15144186 17192257 19690332 27898060 9312162 stimulant N/A OmniPath
ITK CD28 10586033 15144186 19901323 22936936 27898060 8946678 8992971 stimulant N/A OmniPath
IKBKG ITK 20098747 27898060 N/A N/A OmniPath
BTK ITK 11598012 12445832 12573241 27898060 8629002 8630736 stimulant N/A OmniPath
ITK BTK 11598012 12445832 12573241 16497976 27898060 8629002 8630736 N/A N/A OmniPath
ITK KIF2C 17081983 27898060 N/A N/A OmniPath
LCP2 ITK 10556826 10636929 12190313 15388330 27898060 N/A N/A OmniPath
ITK CSF2RB 10329850 10362354 10949031 16437163 27898060 9257712 N/A N/A OmniPath
ITK TEC 12573241 27898060 stimulant N/A OmniPath
ITK SIGLEC10 11733002 27898060 stimulant N/A OmniPath
ITK SDC4 12377772 27898060 N/A N/A OmniPath
ITK DEF6 22829599 27898060 N/A N/A OmniPath
ITK CD6 27898060 9394826 N/A N/A OmniPath
ITK HAVCR2 17069754 26492563 27898060 N/A N/A OmniPath

Visualization










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