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GENE：JAG1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol JAG1
FullNmae jagged canonical Notch ligand 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6188
EnsembleID ENSG00000101384
Uniprot P78504

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
JAG1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
JAG1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
JAG1 GO:0001525,GO:0001709,GO:0001953,GO:0001974,GO:0002011,GO:0002085,GO:0002456,GO:0003180,GO:0003184,GO:0003215,GO:0005112,GO:0005112,GO:0005112,GO:0005198,GO:0005509,GO:0005515,GO:0005543,GO:0005576,GO:0005886,GO:0005886,GO:0005886,GO:0005912,GO:0007219,GO:0007219,GO:0007219,GO:0007399,GO:0008083,GO:0016020,GO:0016020,GO:0016324,GO:0022408,GO:0030097,GO:0030216,GO:0030336,GO:0032495,GO:0035909,GO:0042127,GO:0042491,GO:0045445,GO:0045446,GO:0045599,GO:0045602,GO:0045639,GO:0045665,GO:0045669,GO:0045747,GO:0045944,GO:0050678,GO:0060090,GO:0060090,GO:0060411,GO:0061073,GO:0061101,GO:0061156,GO:0061309,GO:0061314,GO:0061314,GO:0061444,GO:0062043,GO:0072006,GO:0072015,GO:0072017,GO:0072070,GO:0097150,GO:2000241,GO:2000737

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
JAG1 hsa:182 path:hsa01522 Endocrine resistance - Homo sapiens (human)
JAG1 hsa:182 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
JAG1 hsa:182 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
JAG1 hsa:182 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
JAG1 hsa:182 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
JAG1 hsa:182 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
JAG1 hsa:182 path:hsa05200 Pathways in cancer - Homo sapiens (human)
JAG1 hsa:182 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
JAG1 hsa:182 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOTCH1 JAG1 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 22390640 23343194 24023259 25730849 26192618 7542250 8666229 interaction type,stimulation N/A ACSN,SignaLink
JAG1 NUMB 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 26192618 7542250 8666229 interaction type N/A ACSN
MIB2 JAG1 26192618 interaction type N/A ACSN
PSEN1 JAG1 22330899 22363130 26192618 interaction type N/A ACSN
JAG1 TP63 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
JAG1 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
JAG1 NOTCH2 10551863 10958687 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
JAG1 NOTCH1 10958687 11006133 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
MIB1 JAG1 12530964 20720151 21071413 23331499 stimulation N/A SignaLink,SignaLink
LFNG JAG1 15574878 23331499 inhibition N/A SignaLink
MFNG JAG1 12036964 15574878 23331499 inhibition N/A SignaLink
NEURL1 JAG1 15380241 23331499 stimulation N/A SignaLink
RAB11A JAG1 16137758 23331499 stimulation N/A SignaLink
GALM JAG1 15574878 23331499 inhibition N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR JAG1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TP63 JAG1 11641404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 JAG1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 JAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KDM4C JAG1 23698634 trascriptional regulation,stimulation inferred by curator TFlink
PPARG JAG1 20436223 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 JAG1 21637926 trascriptional regulation,stimulation inferred by curator TFlink
SNAI2 JAG1 20509143 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D JAG1 19398721 22618231 \N rna interference,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 JAG1 19398721 20351093 \N rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000027352D JAG1 22113133 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00003BD367 JAG1 22871495 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D JAG1 18591254 18927107 19398721 22618231 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000EED18 JAG1 18927107 19398721 20351093 24307639 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000171525 JAG1 21224848 25416803 26302069 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry TarBase
URS000027352D JAG1 22113133 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000008A99 JAG1 21685392 25416803 mrna cleavage,inhibition array technology,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F4657 JAG1 21685392 25416803 mrna cleavage,inhibition array technology,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BD367 JAG1 22871495 25172935 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000ED600 JAG1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 JAG1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 JAG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000029EBD JAG1 24659709 25416803 27957826 mrna cleavage,inhibition experimental interaction detection,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000160683 JAG1 22336710 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000040EC3B JAG1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000B59A2 JAG1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001E3523 JAG1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD JAG1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 JAG1 25416803 25998143 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS000003ABC4 JAG1 25416803 28203521 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
JAG1 NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 JAG1 25361965 interaction type N/A PTMCode2
JAG1 NOTCH1 25361965 interaction type N/A PTMCode2
NOTCH1 JAG1 25361965 interaction type N/A PTMCode2
JAG1 DLL1 25361965 interaction type N/A PTMCode2
DLL1 JAG1 25361965 interaction type N/A PTMCode2
JAG1 POFUT1 25361965 interaction type N/A PTMCode2
POFUT1 JAG1 25361965 interaction type N/A PTMCode2
LFNG JAG1 25361965 interaction type N/A PTMCode2
JAG1 LFNG 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FBXW7 JAG1 25348397 N/A physical interaction ComPPI
NOTCH1 JAG1 11006133 14525934 18660822 23086448 24234451 25348397 colocalization experimental interaction detection,nuclear magnetic resonance,pull down,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,confocal microscopy,surface plasmon resonance array ComPPI,HPRD,IntAct
HGS JAG1 25348397 N/A physical interaction ComPPI
CANX JAG1 22487239 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CALR JAG1 22487239 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
APBB1 JAG1 25348397 26276215 27898060 N/A physical interaction ComPPI,OmniPath
ADAM17 JAG1 23375636 24234451 25348397 27898060 N/A cleavage assay ComPPI,IntAct,OmniPath
SDCBP2 JAG1 11102519 24234451 25348397 physical association two hybrid ComPPI,IntAct
NOTCH2 JAG1 10551863 10958687 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NOTCH3 JAG1 12482954 14525934 14714274 22487239 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
MIB1 JAG1 25348397 N/A physical interaction ComPPI
CD46 JAG1 23086448 24234451 25348397 colocalization nuclear magnetic resonance,surface plasmon resonance,enzyme linked immunosorbent assay,confocal microscopy ComPPI,IntAct
AFDN JAG1 25348397 N/A physical interaction ComPPI
JAG1 NEURL1 25348397 N/A physical interaction ComPPI
MFNG JAG1 12036964 14525934 N/A experimental interaction detection HPRD
JAG1 POFUT1 12036964 14525934 N/A experimental interaction detection HPRD
JAG1 THBS1 14525934 15258909 27898060 N/A two hybrid HPRD,OmniPath
RAB11A JAG1 16137758 27898060 stimulant N/A OmniPath
WNT1 JAG1 18495817 27898060 stimulant N/A OmniPath
JAG1 CDKN1B 16495313 27898060 stimulant N/A OmniPath
JAG2 JAG1 27898060 9315665 stimulant N/A OmniPath
LFNG JAG1 15574878 27898060 inhibition N/A OmniPath
NOTCH1 JAG1 11006133 16713569 17537801 18495817 18660822 20720151 21820430 23086448 27898060 stimulant N/A OmniPath
JAG1 NOTCH1 11006133 16713569 17537801 18495817 18660822 20720151 21820430 23086448 27898060 7697721 inhibition,stimulant N/A OmniPath
MIB1 JAG1 12530964 18043734 27898060 stimulant N/A OmniPath
JAG1 NOTCH2 10551863 10958687 1095869 11346656 18660822 27898060 inhibition,stimulant N/A OmniPath
JAG1 NOTCH3 11006133 12482954 14714274 18660822 22487239 27898060 inhibition,stimulant N/A OmniPath
JAG1 NOTCH4 24563863 27898060 inhibition N/A OmniPath

Visualization










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