GENE：KCNE1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KCNE1 |
| FullNmae | potassium voltage-gated channel subfamily E regulatory subunit 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6240 |
| EnsembleID | ENSG00000180509 |
| Uniprot | P15382 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KCNE1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KCNE1 | GO:0002070,GO:0005249,GO:0005251,GO:0005251,GO:0005515,GO:0005764,GO:0005886,GO:0005886,GO:0005886,GO:0007605,GO:0008076,GO:0008076,GO:0008584,GO:0009986,GO:0015459,GO:0015459,GO:0016324,GO:0021750,GO:0030018,GO:0031433,GO:0033363,GO:0044325,GO:0044877,GO:0045121,GO:0060307,GO:0060307,GO:0071320,GO:0071468,GO:0071482,GO:0071805,GO:0086002,GO:0086005,GO:0086005,GO:0086008,GO:0086009,GO:0086011,GO:0086011,GO:0086013,GO:0086013,GO:0086091,GO:0086091,GO:0090315,GO:0097623,GO:0097623,GO:0098915,GO:1901379,GO:1901381,GO:1902259,GO:1902260,GO:1902260,GO:1902282,GO:1902282 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| KCNE1 | hsa:3753 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | KCNE1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | KCNE1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | KCNE1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KCNE1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | KCNE1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KCNE1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KCNE1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | KCNE1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | KCNE1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBASH3A | KCNE1 | 25348397 | N/A | physical interaction | ComPPI |
| CALM1 | KCNE1 | 25348397 | N/A | molecular sieving | ComPPI |
| KCNQ1 | KCNE1 | 11101505 11104781 14525934 16914890 19114714 19521339 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction | ComPPI,HPRD,IntAct,OmniPath |
| TPM3 | KCNE1 | 25348397 | N/A | physical interaction | ComPPI |
| ADRB2 | KCNE1 | 25348397 | N/A | physical interaction | ComPPI |
| KCNH2 | KCNE1 | 14525934 25348397 9230439 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| PRKCA | KCNE1 | 14525934 1553557 | N/A | experimental interaction detection | HPRD |
| CALM2 | KCNE1 | 19521339 24234451 | N/A | molecular sieving | IntAct |
| KCNE1 | KCNQ4 | 16301825 27898060 | stimulant | N/A | OmniPath |