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GENE：KCNJ2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KCNJ2
FullNmae potassium inwardly rectifying channel subfamily J member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6263
EnsembleID ENSG00000123700
Uniprot P63252

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KCNJ2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KCNJ2 GO:0005242,GO:0005242,GO:0005515,GO:0005546,GO:0005886,GO:0005886,GO:0006813,GO:0008076,GO:0014704,GO:0014861,GO:0015693,GO:0016020,GO:0030007,GO:0030315,GO:0034765,GO:0042802,GO:0043025,GO:0043197,GO:0045211,GO:0051289,GO:0055119,GO:0060075,GO:0060306,GO:0071260,GO:0071805,GO:0086002,GO:0086004,GO:0086008,GO:0086011,GO:0086012,GO:0086013,GO:0086013,GO:0086091,GO:0090076,GO:0098978,GO:1901381,GO:1990573,GO:1990573

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KCNJ2 hsa:3759 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
KCNJ2 hsa:3759 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
KCNJ2 hsa:3759 path:hsa04924 Renin secretion - Homo sapiens (human)
KCNJ2 hsa:3759 path:hsa04971 Gastric acid secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KCNJ2 SNTA1 15123239 23180781 physical association peptide array InnateDB

Source Target Pmid Interactiontype Methods Database
AR KCNJ2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 KCNJ2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 KCNJ2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001AFC71 KCNJ2 22880819 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001AFC71 KCNJ2 22880819 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000052E1A6 KCNJ2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000034B6F5 KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC KCNJ2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075D860 KCNJ2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 KCNJ2 25416803 25880778 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA KCNJ2 22135298 phosphorylation N/A PhosphoSite
KCNJ2 AKAP5 25361965 interaction type N/A PTMCode2
AKAP5 KCNJ2 25361965 interaction type N/A PTMCode2
KCNJ2 CASK 25361965 interaction type N/A PTMCode2
CASK KCNJ2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SEC22A KCNJ2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DLG4 KCNJ2 10627592 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FLNA KCNJ2 12923176 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,pull down,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
DLG2 KCNJ2 14525934 15304517 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
KCNJ4 KCNJ2 12032359 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CASK KCNJ2 14525934 15024025 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SDCBP KCNJ2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DLG1 KCNJ2 11181181 14525934 24234451 25348397 30126976 N/A experimental interaction detection,physical interaction,in vitro,in vivo,p8 filamentous phage display ComPPI,HPRD,IntAct
IL16 KCNJ2 25348397 N/A two hybrid,in vivo ComPPI
DLG3 KCNJ2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNJ2 KCNJ8 10559219 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
KCNJ2 KCNJ11 25348397 N/A in vitro ComPPI
KCNJ2 PATJ 25348397 N/A in vitro ComPPI
KCNJ2 TRAK2 14525934 16895905 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
KCNJ2 AKAP5 11287423 14525934 24234451 25348397 27898060 physical association experimental interaction detection,pull down ComPPI,HPRD,IntAct,OmniPath
KCNJ2 ARL13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KCNJ2 KCNJ18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KCNJ2 KCNJ2 24234451 physical association two hybrid array,two hybrid prey pooling approach IntAct
KCNJ2 SCRIB 24234451 30126976 N/A p8 filamentous phage display IntAct
KCNJ2 KCNJ16 11240146 27898060 N/A N/A OmniPath
PRKACA KCNJ2 19843922 27898060 N/A N/A OmniPath

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