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GENE：KCNMA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KCNMA1
FullNmae potassium calcium-activated channel subfamily M alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6284
EnsembleID ENSG00000156113
Uniprot Q12791

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KCNMA1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KCNMA1 GO:0001666,GO:0003779,GO:0005249,GO:0005249,GO:0005515,GO:0005886,GO:0005901,GO:0006813,GO:0006970,GO:0008076,GO:0015269,GO:0016020,GO:0016324,GO:0030007,GO:0034465,GO:0034465,GO:0034765,GO:0042311,GO:0042391,GO:0042391,GO:0043065,GO:0045211,GO:0045794,GO:0046872,GO:0051592,GO:0060072,GO:0060072,GO:0060072,GO:0060073,GO:0060083,GO:0071805

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KCNMA1 hsa:3778 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
KCNMA1 hsa:3778 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
KCNMA1 hsa:3778 path:hsa04911 Insulin secretion - Homo sapiens (human)
KCNMA1 hsa:3778 path:hsa04924 Renin secretion - Homo sapiens (human)
KCNMA1 hsa:3778 path:hsa04970 Salivary secretion - Homo sapiens (human)
KCNMA1 hsa:3778 path:hsa04972 Pancreatic secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR KCNMA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 KCNMA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 KCNMA1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C KCNMA1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 KCNMA1 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 KCNMA1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 KCNMA1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 KCNMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF KCNMA1 21072171 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 KCNMA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETV4 KCNMA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB KCNMA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 KCNMA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 KCNMA1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000044FD7 KCNMA1 21072171 rna interference,inhibition array technology,experimental interaction detection miRSponge
URS0000044FD7 KCNMA1 21072171 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS00002075FA KCNMA1 25416803 27245839 mrna cleavage,inhibition array technology,experimental interaction detection,rna immunoprecipitation,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA KCNMA1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CAV1 KCNMA1 25348397 N/A physical interaction ComPPI
PTPRA KCNMA1 25348397 N/A physical interaction ComPPI
HNRNPL KCNMA1 25348397 N/A physical interaction ComPPI
CAV3 KCNMA1 25348397 N/A physical interaction ComPPI
CAV2 KCNMA1 25348397 N/A physical interaction ComPPI
EED KCNMA1 25348397 N/A physical interaction ComPPI
KCNMA1 GGT1 14525934 15528406 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNMA1 KCNMB1 14525934 25348397 27898060 8006036 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
KCNMA1 CACNA1H 14525934 14631046 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
KCNMA1 HMOX2 14525934 15528406 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNMA1 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KCNMA1 ACTA2 25348397 N/A physical interaction ComPPI
KCNMA1 ACTG2 25348397 N/A physical interaction ComPPI
KCNMA1 TBXA2R 20959415 23255603 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,pull down,physical interaction ComPPI,IntAct,OmniPath
KCNMA1 LRRC26 20613726 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KCNMA1 KCNMB2 22710124 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
KCNMA1 KCNMA1 14525934 16081418 N/A experimental interaction detection HPRD
KCNMA1 MAP1A 14525934 15251455 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
TRPC1 KCNMA1 19168436 27898060 N/A N/A OmniPath
KCNMA1 TRPV1 24147119 27898060 N/A N/A OmniPath
PRKCA KCNMA1 19592459 27898060 stimulant N/A OmniPath

Visualization










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