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GENE：LAT

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAT
FullNmae linker for activation of T cells
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18874
EnsembleID ENSG00000213658
Uniprot O43561

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAT lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
LAT lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
LAT immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LAT GO:0001772,GO:0001772,GO:0002250,GO:0002260,GO:0005515,GO:0005794,GO:0005886,GO:0005886,GO:0005911,GO:0006954,GO:0006955,GO:0006955,GO:0007229,GO:0007265,GO:0008180,GO:0010467,GO:0016020,GO:0019722,GO:0019901,GO:0019901,GO:0030159,GO:0035556,GO:0035556,GO:0042110,GO:0043303,GO:0045121,GO:0045860,GO:0045860,GO:0050852,GO:0050863,GO:0050863

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAT hsa:27040 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
LAT hsa:27040 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
LAT hsa:27040 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
LAT hsa:27040 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
LAT hsa:27040 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
LAT hsa:27040 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
LAT hsa:27040 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
LAT hsa:27040 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
LAT hsa:27040 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
LAT hsa:27040 path:hsa05135 Yersinia infection - Homo sapiens (human)
LAT hsa:27040 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GRB2 LAT 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26192618 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483 interaction type N/A ACSN
LAT GRAP 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26192618 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483 interaction type N/A ACSN
PLCG1 LAT 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26192618 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483 interaction type N/A ACSN
ITK LAT 11406363 12186560 15661896 25137453 26192618 interaction type N/A ACSN
CD247 LAT 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 26192618 7600293 8478617 8642247 9625766 9738502 interaction type N/A ACSN
ZAP70 LAT 12415267 12731048 15084594 15735648 17371980 20814939 23109003 23620508 26192618 7600293 8642247 interaction type,chemical activation reaction N/A ACSN,SignaLink
VAV1 LAT 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26192618 26552706 8189062 8226994 9438848 interaction type N/A ACSN
TEC LAT 11406363 15214048 26192618 interaction type N/A ACSN
CD101 LAT 26192618 9647226 interaction type N/A ACSN
LAT LCP2 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26192618 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483 interaction type N/A ACSN
CD2 LAT 10359122 15998796 16081768 19398758 19494291 26192618 26794910 interaction type N/A ACSN
CD48 LAT 10358138 10359122 11390470 12515815 15169881 15713798 15905190 15998796 16081768 16177062 16339513 17171759 20189481 22683124 22786724 26192618 26794910 7890616 9535722 interaction type N/A ACSN
SYK LAT 10358164 10426994 11907067 12524384 12731048 15536084 16713974 19909365 20814939 21149606 21378271 21910624 23609447 26192618 8189062 8226994 9000133 9314552 9396765 9632805 interaction type N/A ACSN
SH2D1A LAT 10358138 10359122 11390470 12515815 15169881 15713798 15905190 15998796 16081768 16177062 16339513 17171759 20189481 22683124 22786724 26192618 26794910 7890616 9535722 interaction type N/A ACSN
LAT SHC1 10072481 10781611 10811803 11169415 12640133 14764585 16102570 16329184 19494291 19909365 23620508 25137453 26192618 7523143 7890616 8649391 8976179 9489702 9535722 interaction type N/A ACSN
PTPN1 LAT 12857726 23180781 physical association in gel phosphatase assay InnateDB
FLOT1 LAT 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
LAT GAB2 11572860 12640133 23109003 chemical activation reaction N/A SignaLink
LAT VAV3 12186560 23109003 chemical activation reaction N/A SignaLink
LAT VAV1 12186560 23109003 chemical activation reaction N/A SignaLink
LAT SH3BP2 15751964 23109003 chemical activation reaction N/A SignaLink
LAT PLCG1 11709089 12941616 15219999 15286727 23109003 chemical activation reaction N/A SignaLink
LAT PIK3R1 14696041 19132916 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
LAT CD4 20005715 interaction type N/A PSP
LAT LCK 20005715 interaction type N/A PSP,SignaLink
LAT FYN 20005715 interaction type N/A PSP,SignaLink
LAT FCGR1A 20005715 interaction type N/A PSP
LAT PLCG2 20005715 interaction type N/A PSP
LAT PTPN1 20005715 interaction type N/A PSP,SignaLink
LAT PLCG1 11368773 16467851 18988627 20005715 21071413 9729044 interaction type N/A PSP,SignaLink
LAT CBL 20005715 interaction type N/A PSP,SignaLink
LAT ZAP70 20005715 interaction type N/A PSP
LAT SYK 20005715 interaction type N/A PSP
LAT ITK 10506192 12186560 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
LAT PTPRJ 20005715 interaction type N/A PSP
LAT MAP4K1 20005715 interaction type N/A PSP,SignaLink
LAT CD244 20005715 interaction type N/A PSP
LAT SYK 11368773 18988627 20005715 20005715 21071413 9891970 N/A N/A SignaLink
LAT ZAP70 11368773 12186560 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 LAT 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LAT 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LAT 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 LAT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LAT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LAT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LAT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LAT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LAT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 LAT 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
LCP2 LAT 14525934 24234451 24584089 25348397 9489702 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SPRY1 LAT 25348397 N/A physical interaction ComPPI
SGTA LAT 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LAT VAV1 11368773 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LAT ZAP70 11368773 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LAT CD8A 10562325 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LAT CD4 10562325 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LAT ITK 10506192 12186560 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LAT GRB2 10811803 14525934 16906159 16938345 24234451 25348397 9489702 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,isothermal titration calorimetry,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
LAT SYK 14525934 25348397 9891970 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT PLCG2 24234451 24642916 25348397 N/A surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,IntAct
LAT SHB 12084069 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT SLA 10449770 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT SH3BP2 11390470 14525934 17306257 24234451 25348397 colocalization cosedimentation through density gradient,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
LAT GRAP2 10021361 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT GAB2 11572860 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT CD244 12077228 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LAT PTPN1 12857726 14525934 24234451 25348397 dephosphorylation reaction,colocalization,physical association cosedimentation,cosedimentation in solution,experimental interaction detection,pull down,physical interaction,phosphatase assay,in vitro ComPPI,HPRD,IntAct
LAT GRAP 14525934 25348397 8995379 9489702 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LAT LCK 12186560 12359715 14525934 16938345 24234451 25348397 phosphorylation reaction,association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
LAT MAP4K1 11279207 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LAT CBL 14525934 25348397 8798643 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT FCGR1A 10781611 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT FCGR2A 10781611 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LAT PLCG1 10811803 11368773 14525934 16467851 16938345 24234451 24642916 25348397 9489702 9729044 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction ComPPI,HPRD,IntAct
LAT PIK3R1 10811803 24234451 25348397 association coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
LAT PTPRJ 11259588 14525934 24234451 25348397 dephosphorylation reaction experimental interaction detection,physical interaction,biochemical ComPPI,HPRD,IntAct
LAT USP19 25348397 N/A physical interaction ComPPI
LAT CD247 25348397 N/A physical interaction ComPPI
LAT CD3E 25348397 N/A physical interaction ComPPI
LAT FYN 16938345 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
LAT SOS1 25348397 N/A physical interaction ComPPI
LAT ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LAT ZHX2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LAT EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
LAT CREB3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAT USP12 25348397 N/A physical interaction ComPPI
LAT PTPN6 25348397 N/A physical interaction ComPPI
LAT LMNA 25348397 N/A physical interaction ComPPI
LAT UBB 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
LAT UBC 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
LAT RPS27A 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
LAT UBA52 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
LAT KASH5 25348397 N/A barcode fusion genetics two hybrid ComPPI
LAT SAR1A 25348397 N/A two hybrid ComPPI
LAT GJB1 25348397 N/A two hybrid ComPPI
LAT CDIP1 25348397 N/A two hybrid ComPPI
LAT BCL2L13 25348397 N/A two hybrid ComPPI
LAT CYBC1 25348397 N/A two hybrid ComPPI
LAT MFSD5 25348397 N/A two hybrid ComPPI
LAT MRPS18B 25348397 N/A two hybrid ComPPI
LAT SGTB 25348397 N/A two hybrid ComPPI
LAT JSRP1 25348397 N/A two hybrid ComPPI
LAT TMEM45B 25348397 N/A two hybrid ComPPI
LAT KCTD17 25348397 N/A two hybrid ComPPI
LAT CLDN2 25348397 N/A two hybrid ComPPI
LAT TM4SF18 25348397 N/A two hybrid ComPPI
LAT MFSD14B 25348397 N/A two hybrid ComPPI
LAT THAP4 25348397 N/A two hybrid ComPPI
LAT SLC19A3 25348397 N/A two hybrid ComPPI
LAT KIR2DL3 25348397 N/A two hybrid ComPPI
LAT CD53 25348397 N/A two hybrid ComPPI
LAT SLPI 25348397 N/A two hybrid ComPPI
LAT MS4A7 25348397 N/A two hybrid ComPPI
LAT TNFRSF10D 25348397 N/A two hybrid ComPPI
LAT CLDN7 25348397 N/A two hybrid ComPPI
LAT SLC51B 25348397 N/A two hybrid ComPPI
LAT CD3G 25348397 N/A two hybrid ComPPI
LAT SYT2 25348397 N/A two hybrid ComPPI
LAT CAMLG 25348397 N/A two hybrid ComPPI
LAT GPR152 25348397 N/A two hybrid ComPPI
LAT LHFPL1 25348397 N/A two hybrid ComPPI
LAT SLC14A2 25348397 N/A two hybrid ComPPI
LAT MAP1LC3C 25348397 N/A two hybrid ComPPI
LAT SSMEM1 25348397 N/A two hybrid ComPPI
LAT CLDN5 25348397 N/A two hybrid ComPPI
LAT GJA8 25348397 N/A two hybrid ComPPI
LAT GPR151 25348397 N/A two hybrid ComPPI
LAT GPR42 25348397 N/A two hybrid ComPPI
LAT LHFPL5 25348397 N/A two hybrid ComPPI
LAT TMEM80 25348397 N/A two hybrid ComPPI
LAT FKBP7 25348397 N/A two hybrid ComPPI
LAT GOLM1 25348397 N/A two hybrid ComPPI
LAT FFAR3 25348397 N/A two hybrid ComPPI
LAT NDUFAF2 25348397 N/A two hybrid ComPPI
LAT LEUTX 25348397 N/A two hybrid ComPPI
LAT THEMIS 21189249 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
TRAF6 LAT 23514740 25348397 25907557 27898060 N/A physical interaction ComPPI,OmniPath
LAT PLCG1 10811803 11368773 16467851 16938345 24642916 27898060 9489702 9729044 stimulant N/A OmniPath
LCK LAT 12186560 12359715 14523017 16938345 27898060 stimulant N/A OmniPath
PTPN1 LAT 12857726 27898060 inhibition N/A OmniPath
LAT PIK3R2 11368773 27898060 stimulant N/A OmniPath
FYN LAT 16938345 27898060 stimulant N/A OmniPath
LAT GRB2 10811803 11368773 12186560 16906159 16938345 23150273 27898060 8063801 9489702 stimulant N/A OmniPath
MAPK3 LAT 15192708 27898060 inhibition N/A OmniPath
LAT PIK3CA 11368773 27898060 stimulant N/A OmniPath
LAT PIK3R1 10811803 11368773 27898060 stimulant N/A OmniPath
SP1 LAT 18343609 27898060 stimulant N/A OmniPath
MAPK8 LAT 15192708 27898060 inhibition N/A OmniPath
ZAP70 LAT 11368773 11395491 12186560 12496416 15029250 16906159 23460737 23514740 23901140 24642916 27898060 stimulant N/A OmniPath
LAT RGS14 23250758 27898060 N/A N/A OmniPath
RGS14 LAT 23250758 27898060 N/A N/A OmniPath
LAT VAV1 11368773 12186560 27898060 stimulant N/A OmniPath
ACP1 LAT 17537991 27898060 N/A N/A OmniPath
PTPRJ LAT 11259588 27898060 inhibition N/A OmniPath

Visualization










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