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GENE：LRP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRP1
FullNmae LDL receptor related protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6692
EnsembleID ENSG00000123384
Uniprot Q07954

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRP1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LRP1 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature

Go Annotation:

GeneSymbol Go id
LRP1 GO:0001523,GO:0001540,GO:0002265,GO:0003723,GO:0005041,GO:0005044,GO:0005509,GO:0005515,GO:0005634,GO:0005765,GO:0005769,GO:0005794,GO:0005856,GO:0005886,GO:0005886,GO:0005886,GO:0005905,GO:0005925,GO:0006629,GO:0006898,GO:0006898,GO:0006898,GO:0006909,GO:0006909,GO:0006909,GO:0007041,GO:0007167,GO:0010629,GO:0010715,GO:0010875,GO:0014912,GO:0016020,GO:0016323,GO:0016964,GO:0016964,GO:0030178,GO:0030226,GO:0030666,GO:0031623,GO:0032050,GO:0032092,GO:0032370,GO:0032374,GO:0032429,GO:0032956,GO:0034185,GO:0034185,GO:0034185,GO:0035909,GO:0038023,GO:0038024,GO:0038024,GO:0038024,GO:0038024,GO:0042953,GO:0043235,GO:0043277,GO:0043395,GO:0044877,GO:0045056,GO:0045807,GO:0060392,GO:0070325,GO:0097242,GO:0097242,GO:0098797,GO:0150093,GO:0150093,GO:0150093,GO:0150094,GO:0150094,GO:0150094,GO:0150104,GO:0150104,GO:1900223,GO:1900223,GO:1903078,GO:1904300,GO:1904646,GO:1905049,GO:1905167,GO:2000587

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LRP1 hsa:4035 path:hsa04148 Efferocytosis - Homo sapiens (human)
LRP1 hsa:4035 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)
LRP1 hsa:4035 path:hsa05010 Alzheimer disease - Homo sapiens (human)
LRP1 hsa:4035 path:hsa05144 Malaria - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR LRP1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 LRP1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
HIF1A LRP1 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 LRP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PPARG LRP1 12551936 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
RXRB LRP1 12551936 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
SREBF1 LRP1 20980003 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SREBF2 LRP1 16697011 20980003 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
FOXP3 LRP1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 LRP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000016914 LRP1 19665999 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000254A6 LRP1 19665999 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002E1509 LRP1 19665999 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000016914 LRP1 18927107 19665999 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000254A6 LRP1 19665999 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002E1509 LRP1 19665999 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 LRP1 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA LRP1 22135298 phosphorylation N/A PhosphoSite
SRC LRP1 22135298 phosphorylation N/A PhosphoSite
PRKCA LRP1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MAPRE1 LRP1 25348397 N/A physical interaction ComPPI
SKIL LRP1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
FOXB1 LRP1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAG LRP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CTSG LRP1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SLC25A6 LRP1 25348397 N/A physical interaction ComPPI
PTGES2 LRP1 25348397 N/A physical interaction ComPPI
MMP14 LRP1 14525934 14645246 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DLG4 LRP1 10827173 14525934 17360663 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
CD82 LRP1 14525934 25348397 9804823 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DAB2 LRP1 25348397 N/A physical interaction ComPPI
SNRNP70 LRP1 25348397 N/A physical interaction ComPPI
SRC LRP1 11854294 12789267 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SHC1 LRP1 12069755 12789267 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
COPS5 LRP1 25348397 N/A physical interaction ComPPI
ELANE LRP1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKACA LRP1 11158305 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSP90AA1 LRP1 20558745 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
FURIN LRP1 14525934 2112085 25348397 8546712 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DAB1 LRP1 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CANX LRP1 14525934 14980518 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SERPINE1 LRP1 14525934 15001579 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PLAT LRP1 10632583 14525934 1502153 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
THBS1 LRP1 14525934 14991768 25348397 27898060 7775583 9045712 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PLAUR LRP1 11359936 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PDGFB LRP1 11854294 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CAV1 LRP1 14525934 14593097 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
SNX17 LRP1 12169628 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DIAPH1 LRP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CALR LRP1 12821648 14525934 14980518 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
APBB1 LRP1 11729193 14525934 15115822 16382151 21968187 24234451 25348397 27898060 9837937 physical association two hybrid,experimental interaction detection,nuclear magnetic resonance,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
HSPA5 LRP1 25348397 N/A physical interaction ComPPI
HSP90B1 LRP1 11861214 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SERPINA1 LRP1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F8 LRP1 12522143 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
APOE LRP1 11421580 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LRP1 C3 10608878 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LRP1 C4BPA 11705989 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
LRP1 CCN2 14525934 14585398 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
LRP1 LTF 14525934 1464627 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LRP1 MDK 10772929 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LRP1 SCN3A 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
LRP1 LPL 1281473 14525934 25348397 27898060 7510694 7989348 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
LRP1 F9 12522212 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LRP1 MMP13 10514495 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LRP1 GTPBP1 14525934 25348397 27898060 9820815 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
LRP1 MMP15 14525934 14645246 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LRP1 MMP16 14525934 14645246 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LRP1 APBA2 10827173 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
LRP1 MAPK8IP1 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
LRP1 GIPC1 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
LRP1 MAPK8IP2 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
LRP1 NOS1AP 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
LRP1 GULP1 11729193 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LRP1 ANAPC10 10827173 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
LRP1 KAT5 12888553 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
LRP1 WNT3A 14525934 14739301 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LRP1 BACE1 14525934 15749709 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
LRP1 A2M 10652313 12194978 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LRP1 LRPAP1 10747918 1374383 14525934 1718973 17326667 24234451 25348397 physical association experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
LRP1 PDIA2 25348397 N/A physical interaction ComPPI
LRP1 CALCR 25348397 N/A physical interaction ComPPI
LRP1 LIPC 14525934 25348397 27898060 7721852 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
LRP1 USP3 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LRP1 RIC8B 25348397 N/A physical interaction ComPPI
LRP1 CC2D1A 25348397 N/A physical interaction ComPPI
LRP1 ANKS1B 25348397 N/A physical interaction ComPPI
LRP1 PID1 25348397 N/A physical interaction ComPPI
LRP1 HNRNPDL 25348397 N/A physical interaction ComPPI
LRP1 FBXO6 25348397 N/A physical interaction ComPPI
LRP1 CUBN 25348397 N/A physical interaction ComPPI
LRP1 CHFR 25348397 N/A physical interaction ComPPI
LRP1 RANBP9 25348397 N/A physical interaction ComPPI
LRP1 APP 12212791 14525934 25348397 27898060 7543026 N/A experimental interaction detection,pull down,physical interaction ComPPI,HPRD,OmniPath
LRP1 EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
LRP1 ZFP41 25348397 N/A physical interaction ComPPI
LRP1 KCTD18 25348397 N/A physical interaction ComPPI
LRP1 INTS6 25348397 N/A physical interaction ComPPI
LRP1 TNKS2 25348397 N/A physical interaction ComPPI
LRP1 TNKS 25348397 N/A physical interaction ComPPI
LRP1 FOXF2 25348397 N/A physical interaction ComPPI
LRP1 BCKDHB 25348397 N/A physical interaction ComPPI
LRP1 TUBB8 25348397 N/A physical interaction ComPPI
LRP1 SAMD1 25348397 N/A physical interaction ComPPI
LRP1 TUBA4A 25348397 N/A physical interaction ComPPI
LRP1 MC1R 25348397 N/A physical interaction ComPPI
LRP1 TUBB3 25348397 N/A physical interaction ComPPI
LRP1 LOXL2 25348397 N/A physical interaction ComPPI
LRP1 MTG2 25348397 N/A physical interaction ComPPI
LRP1 SLC25A30 25348397 N/A physical interaction ComPPI
LRP1 GATB 25348397 N/A physical interaction ComPPI
LRP1 SMOC1 25348397 N/A physical interaction ComPPI
LRP1 C17ORF80 25348397 N/A physical interaction ComPPI
LRP1 HASPIN 25348397 N/A physical interaction ComPPI
LRP1 NME4 25348397 N/A physical interaction ComPPI
LRP1 HARS2 25348397 N/A physical interaction ComPPI
LRP1 TUBA1A 25348397 N/A physical interaction ComPPI
LRP1 TUBB4A 25348397 N/A physical interaction ComPPI
LRP1 SLC25A23 25348397 N/A physical interaction ComPPI
LRP1 LCOR 25348397 N/A physical interaction ComPPI
LRP1 NOCT 25348397 N/A physical interaction ComPPI
LRP1 TCAF1 25348397 N/A physical interaction ComPPI
LRP1 SLC25A25 25348397 N/A physical interaction ComPPI
LRP1 MTO1 25348397 N/A physical interaction ComPPI
LRP1 GLMP 25348397 N/A physical interaction ComPPI
LRP1 PC 25348397 N/A physical interaction ComPPI
LRP1 SLC26A6 25348397 N/A physical interaction ComPPI
LRP1 GFPT2 25348397 N/A physical interaction ComPPI
LRP1 GFPT1 25348397 N/A physical interaction ComPPI
LRP1 TUBB2A 25348397 N/A physical interaction ComPPI
LRP1 NPC2 25348397 N/A physical interaction ComPPI
LRP1 MTPAP 25348397 N/A physical interaction ComPPI
LRP1 TUBB4B 25348397 N/A physical interaction ComPPI
LRP1 RPUSD3 25348397 N/A physical interaction ComPPI
LRP1 GNB2 25348397 N/A physical interaction ComPPI
LRP1 NPRL3 25348397 N/A physical interaction ComPPI
LRP1 ERFE 25348397 N/A physical interaction ComPPI
LRP1 ERAL1 25348397 N/A physical interaction ComPPI
LRP1 GCNT1 25348397 N/A physical interaction ComPPI
LRP1 TUBB2B 25348397 N/A physical interaction ComPPI
LRP1 PTCD2 25348397 N/A physical interaction ComPPI
LRP1 SENP1 25348397 N/A physical interaction ComPPI
LRP1 MAP2K7 25348397 N/A physical interaction ComPPI
LRP1 RTEL1 25348397 N/A physical interaction ComPPI
LRP1 LGALS9 25348397 N/A physical interaction ComPPI
LRP1 HNRNPL 25348397 N/A physical interaction ComPPI
LRP1 GRIN2A 17360663 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP1 C1QA 21054788 24234451 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
LRP1 FCN2 21054788 24234451 25348397 N/A surface plasmon resonance,enzyme linked immunosorbent assay ComPPI,IntAct
LRP1 MBL2 21054788 24234451 25348397 N/A surface plasmon resonance,enzyme linked immunosorbent assay ComPPI,IntAct
LRP1 NOTCH3 20472562 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
ITGB1BP1 LRP1 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SYNJ2BP LRP1 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RPL23 LRP1 25348397 N/A physical interaction ComPPI
HSCB LRP1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
MMP17 LRP1 14525934 14645246 N/A experimental interaction detection HPRD
LRP1 LRP1 14525934 8703036 N/A experimental interaction detection HPRD
EXOSC10 LRP1 12837249 12972615 17704127 19046973 21135092 23580640 24106327 24937447 25319414 27898060 N/A N/A OmniPath
SRC LRP1 11158305 11854294 12789267 18381291 21650223 27898060 stimulant N/A OmniPath
PRKACA LRP1 11158305 19651622 27898060 N/A N/A OmniPath
PRKCA LRP1 15272003 27898060 stimulant N/A OmniPath
AXL LRP1 12069755 27898060 N/A N/A OmniPath
FURIN LRP1 2112085 27898060 8546712 N/A N/A OmniPath
SERPINC1 LRP1 27898060 8626456 stimulant N/A OmniPath
SERPINA1 LRP1 15131125 27898060 8626456 stimulant N/A OmniPath
F2 LRP1 27898060 8626456 stimulant N/A OmniPath
C1QB LRP1 11560994 27898060 N/A N/A OmniPath
FCN2 LRP1 21054788 27898060 N/A N/A OmniPath

Visualization










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