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GENE：LRP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRP2
FullNmae LDL receptor related protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6694
EnsembleID ENSG00000081479
Uniprot P98164

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LRP2 GO:0001523,GO:0001822,GO:0001843,GO:0003139,GO:0003148,GO:0003223,GO:0003281,GO:0005041,GO:0005509,GO:0005515,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0005905,GO:0006629,GO:0006897,GO:0006898,GO:0006898,GO:0006898,GO:0007605,GO:0008584,GO:0009897,GO:0015031,GO:0015889,GO:0016324,GO:0016324,GO:0016324,GO:0017124,GO:0030001,GO:0030424,GO:0030425,GO:0030514,GO:0030669,GO:0030900,GO:0031526,GO:0031904,GO:0031994,GO:0034311,GO:0035904,GO:0038024,GO:0038024,GO:0042359,GO:0042562,GO:0043066,GO:0043235,GO:0043235,GO:0043235,GO:0044321,GO:0045056,GO:0050769,GO:0051087,GO:0051087,GO:0051897,GO:0060068,GO:0060982,GO:0061156,GO:0070062,GO:0070447,GO:0071363,GO:0097242,GO:0140058,GO:0140318,GO:0150104,GO:1904447,GO:1905167

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LRP2 hsa:4036 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
LRP2 hsa:4036 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
LRP2 hsa:4036 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LRP2 LCN2 15670845 23180781 physical association surface plasmon resonance InnateDB
EGR1 LRP2 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
LRP2 SHH 11964399 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 LRP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LRP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LRP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 LRP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 LRP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 LRP2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 LRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFBE3 LRP2 25416803 27241555 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SERPINE1 LRP2 25361965 interaction type N/A PTMCode2
LRP2 SERPINE1 25361965 interaction type N/A PTMCode2
APOE LRP2 25361965 interaction type N/A PTMCode2
LRP2 APOE 25361965 interaction type N/A PTMCode2
APOB LRP2 25361965 interaction type N/A PTMCode2
LRP2 APOB 25361965 interaction type N/A PTMCode2
MAPK8IP1 LRP2 25361965 interaction type N/A PTMCode2
LRP2 MAPK8IP1 25361965 interaction type N/A PTMCode2
LRP2 LCN2 25361965 interaction type N/A PTMCode2
LCN2 LRP2 25361965 interaction type N/A PTMCode2
LRP2 DLG4 25361965 interaction type N/A PTMCode2
DLG4 LRP2 25361965 interaction type N/A PTMCode2
LRP2 ALB 25361965 interaction type N/A PTMCode2
ALB LRP2 25361965 interaction type N/A PTMCode2
LRP2 ANKRA2 25361965 interaction type N/A PTMCode2
ANKRA2 LRP2 25361965 interaction type N/A PTMCode2
LRP2 APBB1 25361965 interaction type N/A PTMCode2
APBB1 LRP2 25361965 interaction type N/A PTMCode2
LRP2 LPL 25361965 interaction type N/A PTMCode2
LPL LRP2 25361965 interaction type N/A PTMCode2
LRP2 DAB2 25361965 interaction type N/A PTMCode2
DAB2 LRP2 25361965 interaction type N/A PTMCode2
LRP2 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 LRP2 25361965 interaction type N/A PTMCode2
LRP2 GIPC1 25361965 interaction type N/A PTMCode2
GIPC1 LRP2 25361965 interaction type N/A PTMCode2
LRP2 DAB1 25361965 interaction type N/A PTMCode2
DAB1 LRP2 25361965 interaction type N/A PTMCode2
LRP2 LDLRAP1 25361965 interaction type N/A PTMCode2
LDLRAP1 LRP2 25361965 interaction type N/A PTMCode2
LRP2 CUBN 25361965 interaction type N/A PTMCode2
CUBN LRP2 25361965 interaction type N/A PTMCode2
LRP2 MAGI1 25361965 interaction type N/A PTMCode2
MAGI1 LRP2 25361965 interaction type N/A PTMCode2
APOH LRP2 25361965 interaction type N/A PTMCode2
LRP2 APOH 25361965 interaction type N/A PTMCode2
TG LRP2 25361965 interaction type N/A PTMCode2
LRP2 TG 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF408 LRP2 25348397 N/A physical interaction ComPPI
ZNF264 LRP2 25348397 N/A physical interaction ComPPI
ZBTB48 LRP2 25348397 N/A physical interaction ComPPI
ZNF223 LRP2 25348397 N/A physical interaction ComPPI
SCGB1A1 LRP2 11278724 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TAFA4 LRP2 25348397 N/A physical interaction ComPPI
LDLRAP1 LRP2 14525934 14528014 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
APPL1 LRP2 21971085 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
DLG4 LRP2 12713445 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
DAB2 LRP2 10769163 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct,OmniPath
CLU LRP2 17260971 25348397 27898060 7768901 9228033 N/A physical interaction ComPPI,OmniPath
DAB1 LRP2 10827173 14525934 25348397 9837937 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
THBS1 LRP2 25348397 N/A physical interaction ComPPI
PDGFD LRP2 25348397 N/A physical interaction ComPPI
MAGI1 LRP2 11274227 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
SNX17 LRP2 25348397 N/A physical interaction ComPPI
DLG2 LRP2 12713445 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
APOE LRP2 11421580 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CCN2 LRP2 25348397 N/A physical interaction ComPPI
SCN3A LRP2 25348397 N/A physical interaction ComPPI
LPL LRP2 14525934 25348397 27898060 7686151 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
SYT1 LRP2 25348397 N/A physical interaction ComPPI
APBA2 LRP2 10827173 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
MAPK8IP1 LRP2 10827173 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
GIPC1 LRP2 10827173 11912251 14525934 16908842 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
ITGB1BP1 LRP2 10827173 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
MAPK8IP2 LRP2 10827173 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
NOS1AP LRP2 10827173 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
SYNJ2BP LRP2 10827173 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
ANAPC10 LRP2 25348397 N/A physical interaction ComPPI
EEA1 LRP2 21971085 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
CBX5 LRP2 21888893 24234451 25348397 association tandem affinity purification ComPPI,IntAct
OCRL LRP2 21971085 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
DLG3 LRP2 12713445 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
CTNNB1 LRP2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ANKS1B LRP2 12508107 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
LRP2BP LRP2 12508107 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
ANKRA2 LRP2 11095640 14525934 22649097 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
VIP LRP2 25348397 N/A physical interaction ComPPI
ARHGAP19 LRP2 25348397 N/A physical interaction ComPPI
LPA LRP2 10073957 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GC LRP2 11717447 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
M6PR LRP2 21971085 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
APOH LRP2 14525934 25348397 27898060 9727058 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
PRSS23 LRP2 25348397 N/A physical interaction ComPPI
RIBC2 LRP2 25348397 N/A physical interaction ComPPI
DLK2 LRP2 25348397 N/A physical interaction ComPPI
LRPAP1 LRP2 11912251 14525934 25348397 27898060 7512726 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
EGFL6 LRP2 25348397 N/A physical interaction ComPPI
FGFRL1 LRP2 25348397 N/A physical interaction ComPPI
OBP2A LRP2 25348397 N/A physical interaction ComPPI
APP LRP2 25348397 N/A physical interaction ComPPI
ABL1 LRP2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
LRP2 RBP1 10203351 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
LRP2 PLAU 14525934 25348397 8344937 N/A experimental interaction detection,physical interaction ComPPI,HPRD
LRP2 ATN1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LRP2 RNASE13 25348397 N/A physical interaction ComPPI
LRP2 ZFP41 25348397 N/A physical interaction ComPPI
LRP2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LRP2 ZSCAN29 25348397 N/A physical interaction ComPPI
LRP2 CCDC59 25348397 N/A physical interaction ComPPI
LRP2 MANSC1 25348397 N/A physical interaction ComPPI
LRP2 SOST 25348397 N/A physical interaction ComPPI
LRP2 INSL6 25348397 N/A physical interaction ComPPI
LRP2 AMBN 25348397 N/A physical interaction ComPPI
LRP2 TAFA3 25348397 N/A physical interaction ComPPI
LRP2 MEPE 25348397 N/A physical interaction ComPPI
ZNF224 LRP2 25348397 N/A physical interaction ComPPI
LRP2 SERPINE1 14525934 8344937 N/A experimental interaction detection HPRD
LRP2 TTR 10982792 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
LRP2 INS 14525934 27898060 9773776 N/A experimental interaction detection HPRD,OmniPath
LRP2 APOB 10330424 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
LRP2 SLC9A3 10364184 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
LRP2 TLN1 10827173 14525934 N/A two hybrid HPRD
LRP2 TG 14525934 9492085 N/A experimental interaction detection HPRD
LRP2 GPRASP1 11274227 14525934 N/A experimental interaction detection,two hybrid HPRD
LRP2 LRP2 11095640 12713445 14525934 N/A experimental interaction detection,two hybrid HPRD
DLG1 LRP2 12713445 14525934 N/A experimental interaction detection,two hybrid HPRD
APBB1 LRP2 14525934 9837937 N/A experimental interaction detection,two hybrid HPRD
CUBN LRP2 11595644 11994745 14525934 N/A experimental interaction detection HPRD
PIP5K1C LRP2 10827173 14525934 N/A experimental interaction detection,two hybrid HPRD
LRP2 LCN2 14525934 15670845 27898060 N/A experimental interaction detection HPRD,OmniPath
LRP2 ALB 11158855 14525934 27898060 8898021 N/A experimental interaction detection HPRD,OmniPath
LRP2 MDK 10772929 14525934 N/A experimental interaction detection HPRD
VDAC2 LRP2 24234451 30021884 physical association cross-linking study IntAct
PPIB LRP2 24234451 30021884 physical association cross-linking study IntAct
LRP2 SHH 11964399 27898060 stimulant N/A OmniPath
SHH LRP2 22340494 27898060 N/A N/A OmniPath
AGT LRP2 15467006 27898060 stimulant N/A OmniPath

Visualization










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