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GENE：MALT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MALT1
FullNmae MALT1 paracaspase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6819
EnsembleID ENSG00000172175
Uniprot Q9UDY8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MALT1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MALT1 GO:0001650,GO:0001923,GO:0002020,GO:0002096,GO:0002726,GO:0004175,GO:0004197,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006508,GO:0006952,GO:0007250,GO:0008233,GO:0009620,GO:0019209,GO:0031398,GO:0031663,GO:0032449,GO:0032449,GO:0032731,GO:0032743,GO:0032991,GO:0036094,GO:0042098,GO:0042113,GO:0042802,GO:0042981,GO:0043066,GO:0043123,GO:0043280,GO:0043621,GO:0045087,GO:0048471,GO:0050852,GO:0050852,GO:0050856,GO:0051092,GO:0051092,GO:0051168,GO:0051603,GO:2000321

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MALT1 hsa:10892 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
MALT1 hsa:10892 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
MALT1 hsa:10892 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
MALT1 hsa:10892 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
MALT1 hsa:10892 path:hsa05131 Shigellosis - Homo sapiens (human)
MALT1 hsa:10892 path:hsa05152 Tuberculosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL10 MALT1 11090634 11262391 11280761 11356195 11460167 12356734 14660645 14695475 15125833 16356855 16809782 16818229 17052756 17301840 17363905 17428801 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 21966355 24074955 24243840 24560716 24699077 24958845 26192618 29145629 interaction type,physical association inferred by curator ACSN,Reactome
CARD11 MALT1 11090634 11280761 11356195 11460167 12356734 14660645 14695475 15125833 16356855 16809782 16818229 17052756 17301840 17363905 17428801 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24243840 24560716 24699077 24958845 26192618 29145629 interaction type,physical association inferred by curator ACSN,Reactome
MALT1 IKBKG 11280761 11356195 11460167 12356734 14660645 16301747 16356855 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 19909372 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845 26192618 29145629 interaction type,physical association inferred by curator ACSN,Reactome
MALT1 RELB 17948050 18264101 21873235 26192618 interaction type N/A ACSN
TRAF6 MALT1 11274345 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412 26192618 interaction type N/A ACSN
MAPK9 MALT1 17189706 23180781 physical association anti tag coimmunoprecipitation InnateDB
MALT1 BCL10 11090634 14695475 15125833 15520247 16356856 18223652 23109003 23180781 physical association,chemical activation reaction anti tag coimmunoprecipitation,two hybrid,pull down InnateDB,SignaLink
MALT1 TNFAIP3 18223652 23180781 cleavage reaction,physical association anti tag coimmunoprecipitation,protease assay InnateDB
MALT1 MALT1 11262391 14695475 16356855 17428801 21966355 23180781 24074955 24243840 29145629 ubiquitination reaction,physical association anti tag coimmunoprecipitation,inferred by curator,enzymatic study InnateDB,Reactome
MALT1 UBE2V2 14695475 23180781 ubiquitination reaction enzymatic study InnateDB
MALT1 UBE2N 14695475 23180781 ubiquitination reaction enzymatic study InnateDB
MALT1 SQSTM1 16874300 23180781 physical association anti tag coimmunoprecipitation InnateDB
MALT1 GPS1 19444310 23180781 physical association anti tag coimmunoprecipitation InnateDB
GPS1 MALT1 19444310 23180781 physical association anti tag coimmunoprecipitation InnateDB
MALT1 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K7 MALT1 10702308 10838074 10882101 11460167 14695475 15125833 15327770 16056267 16186825 16301747 16356855 17158449 17496917 19909372 20038579 20449947 20538596 22069318 29145629 physical association inferred by curator Reactome
IKBKB MALT1 16301747 16356855 19909372 29145629 physical association inferred by curator Reactome
CHUK MALT1 16301747 16356855 19909372 29145629 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
BCL10 MALT1 20005715 interaction type N/A PSP
TAB2 MALT1 20005715 interaction type N/A PSP,SignaLink
SQSTM1 MALT1 20005715 interaction type N/A PSP
TRAF2 MALT1 20005715 interaction type N/A PSP
SQSTM1 MALT1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MALT1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 MALT1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 MALT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 MALT1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MALT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MALT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MALT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MALT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MALT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D MALT1 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00001E0AEA MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002198F3 MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD MALT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000008DA94 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F MALT1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 MALT1 25416803 28286260 mrna cleavage,inhibition array technology,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCQ MALT1 25361965 interaction type N/A PTMCode2
MALT1 PRKCQ 25361965 interaction type N/A PTMCode2
BCL10 MALT1 25361965 interaction type N/A PTMCode2
MALT1 BCL10 25361965 interaction type N/A PTMCode2
CARD10 MALT1 25361965 interaction type N/A PTMCode2
MALT1 CARD10 25361965 interaction type N/A PTMCode2
TRAF6 MALT1 25361965 interaction type N/A PTMCode2
MALT1 TRAF6 25361965 interaction type N/A PTMCode2
MALT1 TRAF3 25361965 interaction type N/A PTMCode2
TRAF3 MALT1 25361965 interaction type N/A PTMCode2
MALT1 MAP3K20 25361965 interaction type N/A PTMCode2
MAP3K20 MALT1 25361965 interaction type N/A PTMCode2
MALT1 CARD11 25361965 interaction type N/A PTMCode2
CARD11 MALT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TNFAIP3 MALT1 25348397 N/A physical interaction ComPPI
TRAF6 MALT1 14525934 15125833 17948050 22528498 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
DAB2 MALT1 25348397 N/A physical interaction ComPPI
PRKCQ MALT1 17363905 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCD MALT1 22528498 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS5 MALT1 19444310 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2G2 MALT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC MALT1 17948050 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
UBE2N MALT1 25348397 N/A physical interaction ComPPI
CASP8 MALT1 22267217 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
IKBKB MALT1 19118383 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF3 MALT1 19917778 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIB1 MALT1 25348397 N/A physical interaction ComPPI
NFKBIA MALT1 25348397 N/A physical interaction ComPPI
HNRNPL MALT1 25348397 N/A physical interaction ComPPI
SQSTM1 MALT1 14525934 16874300 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CAMK2G MALT1 25348397 N/A physical interaction ComPPI
XPO1 MALT1 25348397 N/A physical interaction ComPPI
SUV39H1 MALT1 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRAF2 MALT1 14525934 15125833 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VHL MALT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GPS1 MALT1 19444310 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATXN3 MALT1 25348397 N/A physical interaction ComPPI
PYCARD MALT1 22267217 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MAP3K7 MALT1 17948050 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TAB2 MALT1 17948050 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DIABLO MALT1 25348397 N/A physical interaction ComPPI
CARM1 MALT1 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BIRC3 MALT1 24234451 25348397 27070702 association anti bait coimmunoprecipitation ComPPI,IntAct
BCL10 MALT1 11090634 14525934 17948050 19118383 19444310 21157432 22267217 22528498 24234451 25348397 27070702 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
KDM1A MALT1 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STUB1 MALT1 25348397 N/A physical interaction ComPPI
UBE2V2 MALT1 25348397 N/A physical interaction ComPPI
CARD11 MALT1 17948050 22528498 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CARD14 MALT1 25348397 N/A physical interaction ComPPI
CARD9 MALT1 22267217 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MALT1 CSNK1A1 19118383 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MALT1 IKBKG 17948050 18931663 19494296 24234451 25348397 25748427 27070702 27898060 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
MALT1 RELB 25348397 N/A physical interaction ComPPI
MALT1 USP2 25348397 N/A physical interaction ComPPI
MALT1 HECTD3 23358872 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MALT1 USP9X 25348397 N/A physical interaction ComPPI
MALT1 PRMT6 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MALT1 RNF31 25348397 N/A physical interaction ComPPI
MALT1 RBCK1 25348397 N/A physical interaction ComPPI
MALT1 SHARPIN 24234451 25348397 27070702 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MALT1 MALT1 14525934 14695475 19917778 22158899 24234451 N/A experimental interaction detection,molecular sieving,x-ray crystallography HPRD,IntAct
FADD MALT1 15746428 27898060 N/A N/A OmniPath
MALT1 TNFAIP3 18223652 27898060 N/A N/A OmniPath
TRAF6 MALT1 15125833 17948050 19234489 23264041 25569716 27898060 stimulant N/A OmniPath
MALT1 TAB2 17948050 25748427 27898060 stimulant N/A OmniPath
CARD11 MALT1 17948050 19118383 20685844 23322406 25748427 27898060 stimulant N/A OmniPath

Visualization










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