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GENE：MAOA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAOA
FullNmae monoamine oxidase A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6833
EnsembleID ENSG00000189221
Uniprot P21397

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAOA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAOA ferroptosis 39722679 Mechanistic studies indicated that Cur protected AKI against ferroptosis via inhibition of MAOA thereby regulating 5-hydroxy-L-tryptophan metabolism. retulator signature

Go Annotation:

GeneSymbol Go id
MAOA GO:0005515,GO:0005739,GO:0005739,GO:0005739,GO:0005741,GO:0005829,GO:0006576,GO:0008131,GO:0008131,GO:0009967,GO:0042135,GO:0042420,GO:0050660,GO:0052595,GO:0052596,GO:0097621

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAOA hsa:4128 path:hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human)
MAOA hsa:4128 path:hsa00330 Arginine and proline metabolism - Homo sapiens (human)
MAOA hsa:4128 path:hsa00340 Histidine metabolism - Homo sapiens (human)
MAOA hsa:4128 path:hsa00350 Tyrosine metabolism - Homo sapiens (human)
MAOA hsa:4128 path:hsa00360 Phenylalanine metabolism - Homo sapiens (human)
MAOA hsa:4128 path:hsa00380 Tryptophan metabolism - Homo sapiens (human)
MAOA hsa:4128 path:hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human)
MAOA hsa:4128 path:hsa01100 Metabolic pathways - Homo sapiens (human)
MAOA hsa:4128 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
MAOA hsa:4128 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
MAOA hsa:4128 path:hsa05012 Parkinson disease - Homo sapiens (human)
MAOA hsa:4128 path:hsa05030 Cocaine addiction - Homo sapiens (human)
MAOA hsa:4128 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
MAOA hsa:4128 path:hsa05034 Alcoholism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 MAOA 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA MAOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 MAOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MAOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NHLH2 MAOA 22169038 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 MAOA 16728402 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 MAOA 21168126 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS0000096022 MAOA 21168126 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS0000016914 MAOA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000039A052 MAOA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000284586 MAOA 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 MAOA 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HNRNPL MAOA 25348397 N/A physical interaction ComPPI
NDRG1 MAOA 14525934 17220478 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
MIEF1 MAOA 25348397 N/A physical interaction ComPPI
A2M MAOA 17174955 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
COQ9 MAOA 25348397 N/A physical interaction ComPPI
COX6B1 MAOA 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
MAOB MAOA 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
MAOA MAOA 14525934 16129825 N/A experimental interaction detection HPRD
MAPK14 MAOA 19645722 19650872 27898060 N/A N/A OmniPath

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