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GENE：MASP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MASP2
FullNmae MBL associated serine protease 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6902
EnsembleID ENSG00000009724
Uniprot O00187

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MASP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MASP2 GO:0001855,GO:0001867,GO:0001867,GO:0004252,GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006958,GO:0008233,GO:0048306,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MASP2 hsa:10747 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
MASP2 hsa:10747 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
MASP2 hsa:10747 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MASP2 C2 11527969 23180781 cleavage reaction protease assay InnateDB
C3 MASP2 11527969 23180781 cleavage reaction protease assay InnateDB
MASP2 C4B 11527969 23180781 cleavage reaction protease assay InnateDB
MASP2 FCN1 16116205 23180781 physical association anti tag coimmunoprecipitation InnateDB
PITX3 MASP2 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB
MASP2 C4A 22949645 23180781 physical association x-ray crystallography InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 MASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
SERPING1 MASP2 25361965 interaction type N/A PTMCode2
MASP2 SERPING1 25361965 interaction type N/A PTMCode2
FCN2 MASP2 25361965 interaction type N/A PTMCode2
MASP2 FCN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SERPING1 MASP2 10946292 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MBL2 MASP2 10878362 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FCN2 MASP2 12421953 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MASP1 MASP2 25348397 N/A physical interaction ComPPI
MASP2 MASP2 14525934 15117939 N/A experimental interaction detection HPRD

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