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GENE：MBL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MBL2
FullNmae mannose binding lectin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6922
EnsembleID ENSG00000165471
Uniprot P11226

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MBL2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MBL2 GO:0001867,GO:0001867,GO:0002752,GO:0005102,GO:0005515,GO:0005537,GO:0005537,GO:0005537,GO:0005576,GO:0005581,GO:0005615,GO:0005615,GO:0005615,GO:0005771,GO:0006508,GO:0006953,GO:0006958,GO:0006979,GO:0008228,GO:0009897,GO:0009986,GO:0042742,GO:0042802,GO:0043129,GO:0045087,GO:0048306,GO:0048525,GO:0050766,GO:0050830,GO:0051873,GO:0140374,GO:1903028,GO:1905370

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MBL2 hsa:4153 path:hsa04145 Phagosome - Homo sapiens (human)
MBL2 hsa:4153 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
MBL2 hsa:4153 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
MBL2 hsa:4153 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MBL2 TLR4 19840833 21383675 23180781 physical association anti tag coimmunoprecipitation,far western blotting,solid phase assay InnateDB
LY96 MBL2 19840833 23180781 physical association anti tag coimmunoprecipitation,solid phase assay InnateDB
PTX3 MBL2 21106539 23180781 physical association enzyme linked immunosorbent assay InnateDB
MBL2 APCS 21106539 23180781 physical association enzyme linked immunosorbent assay InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 MBL2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFIC MBL2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000013ABA3 MBL2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 MBL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058878F MBL2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004977C5 MBL2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRAPPC2B MBL2 25348397 N/A physical interaction ComPPI
YBX1 MBL2 22118625 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CALR MBL2 14525934 25348397 27898060 8062452 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
LRP1 MBL2 21054788 24234451 25348397 N/A surface plasmon resonance,enzyme linked immunosorbent assay ComPPI,IntAct
UBQLN2 MBL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PTPRC MBL2 25348397 N/A in vitro,in vivo ComPPI
TRAPPC2 MBL2 25348397 N/A physical interaction ComPPI
MBL2 CALCR 11560994 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MBL2 MASP2 10878362 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MBL2 CD93 14525934 25348397 9476117 N/A experimental interaction detection,in vitro ComPPI,HPRD
MBL2 KRT1 11549596 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MBL2 MASP1 10878362 14525934 25348397 N/A experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,electron tomography,in vivo ComPPI,HPRD
MBL2 MAD2L1 11804586 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MBL2 TLR3 24234451 24530528 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct,OmniPath
MBL2 FCN2 19632990 24234451 25348397 association pull down ComPPI,IntAct
MBL2 MBL2 10368295 14525934 24234451 25579818 N/A experimental interaction detection,comigration in sds page HPRD,IntAct
SLTM MBL2 24234451 30021884 physical association cross-linking study IntAct
TLR4 MBL2 19840833 21383675 27898060 N/A N/A OmniPath
MBL2 TLR4 19840833 21383675 27898060 N/A N/A OmniPath
LY96 MBL2 19840833 27898060 N/A N/A OmniPath

Visualization










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