Gene Information gene info

GENE:MC4R

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MC4R
FullNmae melanocortin 4 receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6932
EnsembleID ENSG00000166603
Uniprot P32245

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MC4R immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MC4R GO:0002024,GO:0004977,GO:0004980,GO:0004980,GO:0004980,GO:0005515,GO:0005737,GO:0005886,GO:0005886,GO:0006112,GO:0007188,GO:0007189,GO:0007189,GO:0007631,GO:0016020,GO:0017046,GO:0019222,GO:0030073,GO:0031625,GO:0032868,GO:0042923,GO:0045780,GO:1903998,GO:1990680,GO:2000252,GO:2000821

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MC4R hsa:4160 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMARCA4 MC4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MC4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MC4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MC4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 MC4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MC4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D MC4R 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA MC4R 22135298 phosphorylation N/A PhosphoSite
MC4R TUBB 25361965 interaction type N/A PTMCode2
TUBB MC4R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NPM1 MC4R 25348397 N/A physical interaction ComPPI
PRKACA MC4R 12639913 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IL1RAP MC4R 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
POMC MC4R 11101306 12165561 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRK2 MC4R 12639913 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ASIP MC4R 14525934 25348397 9058374 N/A experimental interaction detection,in vitro ComPPI,HPRD
MC4R MC1R 12165561 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MC4R NPY 12015205 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MC4R AGRP 10318826 11747427 12815165 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MC4R ATRNL1 14525934 14531729 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
MC4R MGRN1 25348397 N/A physical interaction ComPPI
MC4R MRAP2 19329486 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MC4R MRAP 19329486 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MC4R AIG1 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R ATP6V0E2 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R CD81 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R MAL 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R NPC1 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R PLLP 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R PDIA6 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R TSPAN3 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R TMEM19 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R YIPF3 24234451 28298427 physical association ubiquitin reconstruction IntAct
MC4R TMEM94 24234451 28298427 physical association ubiquitin reconstruction IntAct
PRKACA MC4R 12639913 27898060 stimulant N/A OmniPath
CDK1 MC4R 12639913 27898060 N/A N/A OmniPath
GRK2 MC4R 12639913 27898060 inhibition N/A OmniPath
POMC MC4R 11101306 12165561 20694162 27898060 9058374 stimulant N/A OmniPath
AGRP MC4R 10318826 11747427 12815165 27898060 9299416 9311920 inhibition,stimulant N/A OmniPath

Visualization