Gene Information gene info

  1. Home

GENE：MED1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MED1
FullNmae mediator complex subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9234
EnsembleID ENSG00000125686
Uniprot Q15648

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MED1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MED1 GO:0000122,GO:0000151,GO:0000785,GO:0000902,GO:0000978,GO:0001223,GO:0001525,GO:0001889,GO:0001892,GO:0002088,GO:0002154,GO:0003222,GO:0003406,GO:0003682,GO:0003712,GO:0003712,GO:0003713,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0006357,GO:0006590,GO:0006606,GO:0006702,GO:0007420,GO:0007595,GO:0010628,GO:0010628,GO:0010839,GO:0016020,GO:0016567,GO:0016592,GO:0016592,GO:0016592,GO:0016922,GO:0016922,GO:0030216,GO:0030224,GO:0030331,GO:0030374,GO:0030374,GO:0030518,GO:0031100,GO:0031490,GO:0032968,GO:0033148,GO:0035035,GO:0035050,GO:0035116,GO:0035162,GO:0035357,GO:0035729,GO:0035855,GO:0042789,GO:0042809,GO:0042809,GO:0042809,GO:0042809,GO:0042974,GO:0042974,GO:0042975,GO:0043066,GO:0045023,GO:0045444,GO:0045618,GO:0045648,GO:0045665,GO:0045893,GO:0045944,GO:0045944,GO:0046966,GO:0046966,GO:0046966,GO:0048821,GO:0048822,GO:0050693,GO:0051123,GO:0060218,GO:0060261,GO:0060261,GO:0060335,GO:0060744,GO:0060745,GO:0060750,GO:0061630,GO:0070318,GO:0070562,GO:0070847,GO:0071364,GO:0071383,GO:0097067,GO:0097067,GO:0140296,GO:0140297,GO:1990841,GO:2000347,GO:2001141

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MED1 hsa:5469 path:hsa01522 Endocrine resistance - Homo sapiens (human)
MED1 hsa:5469 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MED1 TSC22D3 16239257 23180781 physical association anti tag coimmunoprecipitation InnateDB
IGFBP1 MED1 16239257 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF8 MED1 16239257 23180781 physical association anti tag coimmunoprecipitation InnateDB
MED1 THRA 10891484 23180781 physical association pull down InnateDB
PPARA MED1 10891484 23180781 physical association pull down InnateDB
MED1 RXRA 10891484 23180781 physical association pull down InnateDB
THRB MED1 10891484 23180781 physical association surface plasmon resonance InnateDB

Source Target Pmid Interactiontype Methods Database
YWHAH MED1 20005715 interaction type N/A PSP
YWHAQ MED1 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MED1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MED1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA MED1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MED1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MED1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AR MED1 17483314 trascriptional regulation,stimulation inferred by curator TFlink
PPARD MED1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG MED1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000016914 MED1 20065103 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000016914 MED1 20065103 22473208 22869146 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000016FF9C MED1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016D2D4 MED1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E3523 MED1 25416803 26461474 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 MED1 22135298 phosphorylation N/A PhosphoSite
MAPK3 MED1 22135298 phosphorylation N/A PhosphoSite
PRKDC MED1 22135298 phosphorylation N/A PhosphoSite
CDK2 MED1 22135298 phosphorylation N/A PhosphoSite
MAPK1 MED1 22135298 phosphorylation N/A PhosphoSite
ATM MED1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 MED1 25348397 N/A physical interaction ComPPI
HNRNPC MED1 25348397 N/A physical interaction ComPPI
BAG3 MED1 25348397 N/A physical interaction ComPPI
RARA MED1 14525934 17641689 21478865 24234451 25303530 25348397 9653119 association,physical association two hybrid,cosedimentation in solution,experimental interaction detection,molecular sieving,pull down,physical interaction,x ray scattering ComPPI,HPRD,IntAct
TP53BP1 MED1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
MED21 MED1 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED8 MED1 12584197 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPAG5 MED1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
STN1 MED1 25348397 N/A physical interaction ComPPI
EMC2 MED1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EZH2 MED1 25348397 N/A physical interaction ComPPI
FBXW7 MED1 25348397 N/A physical interaction ComPPI
POU1F1 MED1 25348397 N/A physical interaction ComPPI
AR MED1 12218053 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
VDR MED1 12796488 14525934 21478865 24234451 25348397 9653119 physical association two hybrid,cosedimentation in solution,experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TRIP4 MED1 25348397 N/A physical interaction ComPPI
GATA1 MED1 11724781 14525934 17132730 24234451 25348397 27898060 association,physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
THRA MED1 14525934 24234451 25348397 9653119 physical association anti tag coimmunoprecipitation,experimental interaction detection,far western blotting,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
THRB MED1 14525934 25348397 9325263 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPARA MED1 24234451 25348397 9653119 physical association pull down,in vitro,in vivo ComPPI,IntAct
MED1 MED14 14525934 15175163 20098423 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MED1 MED12 14525934 15175163 20098423 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MED1 HNF4A 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MED1 RORA 10478845 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
MED1 YWHAH 11266503 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED1 PPARG 12037571 14525934 15604093 16554032 24234451 25348397 9325263 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MED1 ESR2 11867769 14525934 21182203 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MED1 PPARGC1A 14525934 14636573 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MED1 GATA4 11724781 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED1 MED25 14525934 14983011 17641689 20098423 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MED1 MED9 14525934 14638676 15175163 24234451 24882805 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MED1 NR1I3 14525934 15572376 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MED1 MDM2 14525934 15848166 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MED1 BRCA1 14525934 15208681 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
MED1 NR1H2 14525934 15604093 24234451 25348397 26120082 N/A two hybrid,fluorescent resonance energy transfer,physical interaction,two hybrid ComPPI,HPRD,IntAct
MED1 GATA3 11724781 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED1 ESR1 14525934 24234451 25348397 9653119 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MED1 NR4A1 12082103 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED1 MED10 14576168 14638676 15175163 24234451 24882805 25348397 association,physical association anti tag coimmunoprecipitation,electron microscopy,physical interaction,ion exchange chromatography ComPPI,IntAct
MED1 MED29 14638676 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED19 14576168 14638676 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED26 15175163 20098423 21729782 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 NR3C1 25348397 N/A physical interaction ComPPI
MED1 TGS1 25348397 N/A physical interaction ComPPI
MED1 TP53 11118038 14525934 15848166 24234451 25348397 9444950 physical association affinity chromatography technology,anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
MED1 CDK8 18418385 20098423 23602568 24234451 25348397 26496610 29568061 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,ion exchange chromatography,biochemical,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
MED1 THRAP3 24234451 25348397 9653119 association molecular sieving,physical interaction ComPPI,IntAct
MED1 MED24 20098423 24234451 25348397 9653119 association anti bait coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
MED1 MED13 20098423 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED6 25348397 N/A physical interaction ComPPI
MED1 MED16 20098423 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED17 20098423 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED20 25348397 N/A physical interaction ComPPI
MED1 MED23 20098423 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED27 25348397 N/A physical interaction ComPPI
MED1 MED4 11470794 11555651 12468546 15989967 20133760 22939629 24234451 24882805 25281560 25348397 26344197 27898060 9892641 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
MED1 MED30 25348397 N/A physical interaction ComPPI
MED1 MED22 25348397 N/A physical interaction ComPPI
MED1 MED31 25348397 N/A physical interaction ComPPI
MED1 MED15 20098423 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED11 25348397 N/A physical interaction ComPPI
MED1 POLR2A 25348397 N/A physical interaction ComPPI
MED1 POLR2F 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 GABPA 16574658 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MED1 ATM 25348397 N/A physical interaction ComPPI
MED1 GATA2 25348397 N/A physical interaction ComPPI
MED1 PARP1 25348397 N/A physical interaction ComPPI
MED1 RXRA 14525934 21478865 24234451 25348397 9653119 physical association cosedimentation in solution,experimental interaction detection,molecular sieving,pull down,physical interaction,x ray scattering ComPPI,HPRD,IntAct
MED1 TRRAP 18418385 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 SREBF1 25348397 N/A pull down,pull down,physical interaction,physical interaction ComPPI
MED1 KAT2A 18418385 24234451 25348397 association physical interaction,biochemical ComPPI,IntAct
MED1 SUPT3H 25348397 N/A physical interaction ComPPI
MED1 SUPT7L 25348397 N/A physical interaction ComPPI
MED1 MYC 25348397 N/A physical interaction ComPPI
MED1 CCNC 20098423 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 CDK19 15175163 23602568 24234451 25348397 association,physical association physical interaction,ion exchange chromatography,tandem affinity purification ComPPI,IntAct
MED1 POLR2E 25348397 N/A physical interaction ComPPI
MED1 CDK9 25348397 N/A physical interaction ComPPI
MED1 ZC3H13 25348397 N/A physical interaction ComPPI
MED1 QKI 25348397 N/A physical interaction ComPPI
MED1 TADA2A 20508642 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 KIF1A 25348397 N/A physical interaction ComPPI
MED1 BRD4 25348397 N/A anti bait coimmunoprecipitation,anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
MED1 CTDP1 25348397 N/A physical interaction ComPPI
MED1 NCOA6 25348397 N/A physical interaction ComPPI
MED1 ELAVL1 25348397 N/A physical interaction ComPPI
MED1 ZNF281 25348397 N/A physical interaction ComPPI
MED1 ZNF326 25348397 N/A physical interaction ComPPI
MED1 RALY 25348397 N/A physical interaction ComPPI
MED1 SETD7 25348397 N/A physical interaction ComPPI
MED1 MED13L 25348397 N/A physical interaction ComPPI
MED1 EPAS1 25348397 N/A physical interaction ComPPI
MED1 GJB5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MED1 POLL 25348397 N/A physical interaction ComPPI
MED1 TCL1B 25348397 N/A physical interaction ComPPI
MED1 NTRK1 25348397 N/A physical interaction ComPPI
MED1 POLR2G 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 PPP4R3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED1 MED12L 25348397 N/A physical interaction ComPPI
MED1 RPAP2 25348397 N/A physical interaction ComPPI
MED1 POLR2D 25348397 N/A physical interaction ComPPI
MED1 BIRC5 25348397 N/A physical interaction ComPPI
MED1 PLK1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
MED1 AHR 25348397 N/A physical interaction ComPPI
MED1 SREBF2 16799563 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
MED1 NR1H3 24234451 25348397 26120082 N/A fluorescent resonance energy transfer ComPPI,IntAct
MED1 NUTM1 25348397 N/A anti bait coimmunoprecipitation ComPPI
YWHAQ MED1 25348397 N/A physical interaction ComPPI
MED28 MED1 25348397 N/A physical interaction ComPPI
MED18 MED1 25348397 N/A physical interaction ComPPI
MED7 MED1 24234451 24882805 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEUR MED1 25348397 N/A anti tag coimmunoprecipitation ComPPI
MED1 GRK 15710747 24234451 25348397 physical association physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
MED1 MED1 12037571 12562779 14525934 9444950 N/A experimental interaction detection HPRD
GATA6 MED1 11724781 14525934 N/A experimental interaction detection HPRD
STC2 MED1 23746844 24234451 association chromatin immunoprecipitation assay IntAct
MED1 ANKRD37 23746844 24234451 association chromatin immunoprecipitation assay IntAct
MED1 GREB1 24234451 25303530 association chromatin immunoprecipitation assay IntAct
NUDCD1 MED1 24234451 29021621 association anti tag coimmunoprecipitation IntAct
LRRC59 MED1 24234451 30021884 physical association cross-linking study IntAct
CEBPB MED1 18339625 27898060 N/A N/A OmniPath
MAPK3 MED1 12356758 16314496 27898060 stimulant N/A OmniPath
MAPK1 MED1 12356758 16314496 27898060 stimulant N/A OmniPath
PRKDC MED1 12356758 16314496 23850489 25481872 27898060 N/A N/A OmniPath

Visualization










  Return