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GENE：MMP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MMP3
FullNmae matrix metallopeptidase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7173
EnsembleID ENSG00000149968
Uniprot P08254

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MMP3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MMP3 GO:0004175,GO:0004222,GO:0004222,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006508,GO:0008233,GO:0008237,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0030574,GO:0031012,GO:0031334,GO:0034614,GO:0045087,GO:0071222,GO:0071492,GO:0071732,GO:0150077,GO:1904645,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MMP3 hsa:4314 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
MMP3 hsa:4314 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MMP3 hsa:4314 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
MMP3 hsa:4314 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
MMP3 hsa:4314 path:hsa05215 Prostate cancer - Homo sapiens (human)
MMP3 hsa:4314 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
MMP3 hsa:4314 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MMP3 10048576 15001984 15003528 15111329 15181457 16079281 16391805 16556862 16682805 17615296 17872466 18337545 19208835 19564415 20589835 21041997 21081489 21317430 22439866 22608498 23691193 24376839 26192618 7512751 7528107 8844971 9157999 9811054 interaction type N/A ACSN
MMP3 RAC1 16001073 20015200 21667018 22880008 26192618 interaction type N/A ACSN
MMP3 MMP9 26192618 interaction type N/A ACSN
MMP3 MMP1 26192618 interaction type N/A ACSN
SPARC MMP3 12867428 23180781 protein cleavage protease assay InnateDB
MMP3 LGALS8 12881409 23180781 physical association pull down InnateDB
MMP3 ETS1 23180781 24111521 physical association anti tag coimmunoprecipitation InnateDB
MMP3 RELA 23180781 24416274 physical association anti tag coimmunoprecipitation InnateDB
MMP3 NFKB1 23180781 24416274 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ERG MMP3 8957070 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ETS1 MMP3 10358095 10949659 11556732 12034715 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay,surface plasmon resonance array TFlink
NFKB1 MMP3 11376631 19275880 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ZNF148 MMP3 15003528 19275880 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF MMP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 MMP3 10358095 trascriptional regulation,stimulation inferred by curator TFlink
FOS MMP3 9334186 trascriptional regulation,stimulation inferred by curator TFlink
JUN MMP3 1429874 15777790 9334186 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIA MMP3 11376631 trascriptional regulation,stimulation inferred by curator TFlink
RELA MMP3 11376631 trascriptional regulation,stimulation inferred by curator TFlink
SOX2 MMP3 22184093 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 MMP3 17460772 23967200 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 MMP3 N/A trascriptional regulation,stimulation inferred by curator TFlink
FLI1 MMP3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 MMP3 25416803 25818544 26175939 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
DCN MMP3 25361965 interaction type N/A PTMCode2
MMP3 DCN 25361965 interaction type N/A PTMCode2
SERPINE1 MMP3 25361965 interaction type N/A PTMCode2
MMP3 SERPINE1 25361965 interaction type N/A PTMCode2
MMP3 SPP1 25361965 interaction type N/A PTMCode2
SPP1 MMP3 25361965 interaction type N/A PTMCode2
ACAN MMP3 25361965 interaction type N/A PTMCode2
MMP3 ACAN 25361965 interaction type N/A PTMCode2
TIMP1 MMP3 25361965 interaction type N/A PTMCode2
MMP3 TIMP1 25361965 interaction type N/A PTMCode2
CCL13 MMP3 25361965 interaction type N/A PTMCode2
MMP3 CCL13 25361965 interaction type N/A PTMCode2
TIMP3 MMP3 25361965 interaction type N/A PTMCode2
MMP3 TIMP3 25361965 interaction type N/A PTMCode2
CCL2 MMP3 25361965 interaction type N/A PTMCode2
MMP3 CCL2 25361965 interaction type N/A PTMCode2
MMP3 MMP3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
COL1A2 MMP3 25348397 N/A protease assay ComPPI
HBD MMP3 25348397 N/A physical interaction ComPPI
MEOX2 MMP3 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MMP3 SERPINE1 10967118 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 TIMP3 11827795 14525934 25348397 N/A experimental interaction detection,physical interaction,protease assay,in vitro,in vivo ComPPI,HPRD
MMP3 TIMP1 12475252 12834347 14525934 25348397 27898060 9288970 N/A experimental interaction detection,physical interaction,enzymatic study,in vitro ComPPI,HPRD,OmniPath
MMP3 BCAN 10986281 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MMP3 CCL13 12149192 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 CCL8 12149192 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 SPOCK1 12810672 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 SPOCK3 11751414 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MMP3 HAPLN1 14525934 25348397 7694569 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 TNFSF11 14525934 15894268 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 SPP1 11375993 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 PLG 14525934 25348397 9548733 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 ACAN 14525934 25348397 7998967 N/A experimental interaction detection,protease assay,in vitro ComPPI,HPRD
MMP3 IGFBP3 14525934 25348397 7523391 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP3 CCL2 12149192 14525934 25348397 9558113 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MMP3 CCL7 25348397 N/A in vitro,in vivo ComPPI
MMP3 SPARC 12867428 25348397 27898060 N/A protease assay ComPPI,OmniPath
MMP3 TIMP2 25348397 N/A surface plasmon resonance ComPPI
MMP3 KIAA0319L 25348397 N/A physical interaction ComPPI
MMP3 MMP10 25348397 N/A physical interaction ComPPI
MMP3 CLU 25348397 N/A physical interaction ComPPI
MMP3 PTPRS 25348397 N/A physical interaction ComPPI
MMP3 CLN5 25348397 N/A physical interaction ComPPI
MMP3 NUCB1 25348397 N/A physical interaction ComPPI
MMP3 APOE 25348397 N/A physical interaction ComPPI
MMP3 LTBP1 25348397 N/A physical interaction ComPPI
MMP3 MMP14 25348397 N/A physical interaction ComPPI
MMP3 MMP3 10543949 10639284 10669564 10877850 11297453 11327577 14525934 9733482 9873489 9888835 N/A experimental interaction detection HPRD
MMP3 DCN 14525934 9148753 N/A experimental interaction detection HPRD
MMP3 NFKB1 24416274 27898060 N/A N/A OmniPath
MMP3 RELA 24416274 27898060 N/A N/A OmniPath
MMP3 CCL2 12149192 27898060 9558113 N/A N/A OmniPath
MMP3 HBEGF 11043579 27898060 stimulant N/A OmniPath
MMP3 CCL7 10947989 12149192 27898060 N/A N/A OmniPath

Visualization










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