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GENE：MSX2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MSX2
FullNmae msh homeobox 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7392
EnsembleID ENSG00000120149
Uniprot P35548

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MSX2 pyroptosis 34041852 Our data delineate a putative mechanism: the absence of Msx2 causes the proliferation and keratinization of squamous epithelial cells, which caused ameloblasts to separate from the epithelial layers and pyroptosis occurred in the enamel organ from the early stage of enamel secretion. retulator signature
MSX2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MSX2 GO:0000122,GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000981,GO:0000981,GO:0000981,GO:0001227,GO:0001649,GO:0002063,GO:0002076,GO:0003148,GO:0003161,GO:0003198,GO:0003416,GO:0005515,GO:0005634,GO:0005667,GO:0005829,GO:0006357,GO:0008285,GO:0009952,GO:0016607,GO:0023019,GO:0030509,GO:0030513,GO:0035115,GO:0035116,GO:0035313,GO:0035880,GO:0043066,GO:0043565,GO:0045599,GO:0045617,GO:0045669,GO:0045892,GO:0048598,GO:0048863,GO:0051795,GO:0060346,GO:0060363,GO:0060364,GO:0060444,GO:0061311,GO:0070166,GO:0071392,GO:0090427,GO:0097152,GO:1990837,GO:2000678,GO:2001055

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MSX2 hsa:4488 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 MSX2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 MSX2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 MSX2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 MSX2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MSX2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 MSX2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MSX2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MSX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MSX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MSX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MSX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MSX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MSX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000214763 MSX2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F MSX2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004DB7E MSX2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000057FDB8 MSX2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001067D1 MSX2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F6E49 MSX2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000D6C3F MSX2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA MSX2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 MSX2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C MSX2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 MSX2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 MSX2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003D5391 MSX2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCB MSX2 22135298 phosphorylation N/A PhosphoSite
MSX2 MAGED1 25361965 interaction type N/A PTMCode2
MAGED1 MSX2 25361965 interaction type N/A PTMCode2
MSX2 SPEN 25361965 interaction type N/A PTMCode2
SPEN MSX2 25361965 interaction type N/A PTMCode2
MSX2 GTF2F1 25361965 interaction type N/A PTMCode2
GTF2F1 MSX2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIAS2 MSX2 14525934 25348397 9256341 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TSSK3 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK1IP1L MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RHOXF2 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ROR2 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATXN1 MSX2 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
ZC3H10 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ANKRD40 MSX2 25348397 N/A physical interaction ComPPI
PITX1 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TLE1 MSX2 25348397 N/A physical interaction ComPPI
MAPK1 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POU1F1 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GTF2F2 MSX2 14525934 25348397 9265625 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RUNX2 MSX2 11683913 14525934 15060165 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
XRCC5 MSX2 12145310 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
XRCC6 MSX2 12145307 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPARG MSX2 25348397 N/A physical interaction ComPPI
POLR3D MSX2 25348397 N/A physical interaction ComPPI
GTF2F1 MSX2 14525934 25348397 9265625 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ZBTB17 MSX2 14525934 25348397 9256341 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAGED1 MSX2 11084035 11959851 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DLX5 MSX2 14525934 25348397 9111364 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NR3C1 MSX2 25348397 N/A physical interaction ComPPI
TOLLIP MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TLE2 MSX2 25348397 N/A physical interaction ComPPI
SPEN MSX2 10451362 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
POU2AF1 MSX2 25348397 N/A physical interaction ComPPI
FOXH1 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TLX3 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GATA2 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLIC3 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CEBPA MSX2 12925529 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
MSX2 DLX2 14525934 25348397 9111364 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MSX2 MSX1 14525934 25348397 9111364 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MSX2 ZDHHC2 25348397 N/A physical interaction ComPPI
MSX2 HBS1L 25348397 N/A physical interaction ComPPI
MSX2 ZNF703 25348397 N/A physical interaction ComPPI
MSX2 NAF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 PRR13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 LENG8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 YTHDF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 SMAP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 CCDC102B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 VEZF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 POU6F2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 RBPMS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TENT5D MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HOXC9 MSX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSX2 MSX2 14525934 9111364 N/A experimental interaction detection HPRD
PRKCB MSX2 22633971 27898060 N/A N/A OmniPath
MSX2 SPEN 10451362 19835636 27898060 stimulant N/A OmniPath

Visualization










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