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GENE：MYD88

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MYD88
FullNmae MYD88 innate immune signal transduction adaptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7562
EnsembleID ENSG00000172936
Uniprot Q99836

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MYD88 pyroptosis 40292295 The AREG-neutralizing antibody reduced LPS-induced epidermal growth factor receptor (EGFR) activation, TLR4 expression, and pyroptosis. Extracellular AREG-induced macrophage pyroptosis decreased with EGFR and NF-κB inhibition, as well as TLR4 and Myd88 knockout. retulator signature
MYD88 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
MYD88 apoptosis 39647467 PHI inhibited inflammatory responses and alleviated apoptosis by reducing the expression levels of IL-6, TNF-α, IL-1β, TLR4, MyD88, NF-κB, and cleaved caspase-3, while enhancing the phosphorylation of PI3K, AKT, GSK3β (Ser9), and pro-caspase-3 in MPCs under HG conditions in vitro. retulator signature

Go Annotation:

GeneSymbol Go id
MYD88 GO:0002238,GO:0002269,GO:0002283,GO:0002755,GO:0005121,GO:0005123,GO:0005149,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006338,GO:0006909,GO:0006915,GO:0007165,GO:0007166,GO:0007249,GO:0007254,GO:0008063,GO:0009682,GO:0009986,GO:0010008,GO:0010467,GO:0010628,GO:0014004,GO:0014070,GO:0014075,GO:0016064,GO:0019897,GO:0031234,GO:0031663,GO:0032481,GO:0032494,GO:0032722,GO:0032731,GO:0032740,GO:0032747,GO:0032755,GO:0032757,GO:0032760,GO:0032991,GO:0034142,GO:0034142,GO:0034158,GO:0035325,GO:0038172,GO:0042742,GO:0042802,GO:0042832,GO:0043123,GO:0043200,GO:0043588,GO:0043621,GO:0045087,GO:0045471,GO:0045944,GO:0046330,GO:0048661,GO:0050671,GO:0050727,GO:0050830,GO:0050830,GO:0051092,GO:0051607,GO:0060090,GO:0060337,GO:0060907,GO:0070498,GO:0070555,GO:0070935,GO:0070944,GO:0070976,GO:0071222,GO:0071260,GO:0090557,GO:0140052,GO:0140674,GO:1900017,GO:1900017,GO:1900227,GO:1902622,GO:2000338,GO:2000341

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MYD88 hsa:4615 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MYD88 hsa:4615 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
MYD88 hsa:4615 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
MYD88 hsa:4615 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
MYD88 hsa:4615 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05131 Shigellosis - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05132 Salmonella infection - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05133 Pertussis - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05134 Legionellosis - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05135 Yersinia infection - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05140 Leishmaniasis - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05142 Chagas disease - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05144 Malaria - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05152 Tuberculosis - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05161 Hepatitis B - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05162 Measles - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05164 Influenza A - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
MYD88 hsa:4615 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MYD88 IL1R1 11274345 12609980 12620219 12659850 12682231 12738796 14660645 15125833 15905496 16252010 16286016 16354686 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 19940113 21614932 23070005 23180781 23681101 23811849 26192618 interaction type,physical association anti tag coimmunoprecipitation,gst pull down ACSN,InnateDB
MYD88 IL1RAP 11274345 12620219 12682231 13679373 14660645 15849357 16878026 17704786 18977329 19161412 23180781 23681101 23811849 26192618 9374458 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MYD88 IRAK4 10679398 11274345 11592085 11960013 11964313 12150927 12620219 12682231 12860405 12907458 14504095 14607900 14660645 14662834 15084582 15099563 15749884 15749903 15802534 15905496 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17486091 17704786 18633355 18977329 19161412 19167362 20485341 20547845 20966070 21372296 21826665 23180781 23508573 23681101 23811849 26192618 26885855 27048821 27066895 9469432 9743347 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,pull down,x-ray crystallography ACSN,InnateDB
MYD88 CD14 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 LY96 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 TIRAP 11274345 11526399 11544529 11964313 12620219 12682231 12888566 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 19506249 20547845 21372296 21826665 21873236 23180781 23508573 23681101 23811849 24265315 26192618 9743347 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,gst pull down,pull down ACSN,InnateDB
MYD88 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 IL18 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
MYD88 IL18R1 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
MYD88 IL18RAP 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
MYD88 IRAK1 10679398 11274345 11592085 11976320 12538665 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16024789 16252010 16878026 16951367 17228323 17276401 17704786 17785432 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 21903422 23070005 23180781 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MYD88 TRAF6 11274345 12620219 12738796 14660645 15125833 16252010 16517750 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23180781 23681101 23811849 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MYD88 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 PYCARD 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 CXCL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
HMGB1 MYD88 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
LTF MYD88 18364398 24088817 26192618 interaction type N/A ACSN
IFNG MYD88 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
STAT1 MYD88 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 26192618 6357187 7594497 8683106 8871614 interaction type N/A ACSN
MYD88 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 VEGFA 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 MAP2K6 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 interaction type N/A ACSN
MYD88 TLR4 12646618 12888566 15728506 17126326 17228323 19717524 23180781 9625770 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB
PIK3R1 MYD88 16644730 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 MYD88 10383454 12659850 20485341 23180781 9374458 physical association anti tag coimmunoprecipitation,gst pull down,pull down,x-ray crystallography InnateDB
MYD88 TLR3 12646618 23180781 physical association gst pull down InnateDB
MYD88 MYD88 11544529 16482509 17228323 17548806 20966070 21325272 23180781 26467481 bind,physical association,up-regulates activity anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer InnateDB,Signor
MYD88 TLR2 16482509 16893894 17126326 19717524 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid InnateDB
IRF7 MYD88 15361868 16484229 17018642 18924132 23180781 physical association anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer InnateDB
MYD88 IRAK3 10383454 12150927 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 BTK 12724322 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 MYD88 15866876 23180781 9430229 physical association anti tag coimmunoprecipitation InnateDB
RAC1 MYD88 11416133 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 PELI1 16951688 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAP2 MYD88 16365431 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 TLR5 16482509 16644730 20855887 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TLR10 MYD88 15728506 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 IRF1 17018642 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
MYD88 IRF5 17018642 23180781 physical association fluorescent resonance energy transfer InnateDB
SIGIRR MYD88 15866876 20364327 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 SYK 17228323 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 TRIP6 15657077 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 TLR7 16482509 23180781 physical association two hybrid InnateDB
MYD88 TLR8 16482509 23180781 physical association two hybrid InnateDB
TLR5 MYD88 16644730 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 FADD 17785432 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR1 MYD88 19717524 22673208 23180781 physical association affinity chromatography technology,two hybrid,pull down InnateDB
TLR6 MYD88 19717524 23180781 physical association affinity chromatography technology,two hybrid InnateDB
MYD88 IRF4 18188453 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 TLR9 15107846 17417641 23180781 physical association anti tag coimmunoprecipitation,unspecified method InnateDB
MYD88 BCL6 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 MYD88 20348427 22673208 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
LRRFIP2 MYD88 21220426 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 IRF3 21248248 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 TNFRSF13B 20676093 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MYD88 EGR1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 CCT8 21827211 23180781 physical association pull down InnateDB
MYD88 YWHAE 21827211 23180781 physical association pull down InnateDB
MYD88 HSP90AA1 21827211 23180781 physical association pull down InnateDB
MYD88 ATXN2L 21827211 23180781 physical association pull down InnateDB
MYD88 TUBA1B 21827211 23180781 physical association pull down InnateDB
MYD88 TUBA1A 21827211 23180781 physical association pull down InnateDB
MYD88 CCT2 21827211 23180781 physical association pull down InnateDB
MYD88 CCT4 21827211 23180781 physical association pull down InnateDB
MYD88 CCT7 21827211 23180781 physical association pull down InnateDB
MYD88 DDX6 21827211 23180781 physical association pull down InnateDB
MYD88 HSPA8 21827211 23180781 physical association pull down InnateDB
MYD88 TUBB 21827211 23180781 physical association pull down InnateDB
MYD88 HSPA1L 21827211 23180781 physical association pull down InnateDB
MYD88 SF3A3 21827211 23180781 physical association pull down InnateDB
MYD88 HSPA6 21827211 23180781 physical association pull down InnateDB
AGER MYD88 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 MYD88 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 MAL 22485159 23180781 physical association pull down InnateDB
MYD88 TICAM2 23180781 24265315 physical association anti tag coimmunoprecipitation InnateDB
IRF4 MYD88 23180781 24670424 physical association anti tag coimmunoprecipitation,proximity ligation assay InnateDB
MYD88 TXN 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MYD88 SPOP 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MYD88 SMAD3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 SIAH1 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 USP7 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM2 MYD88 22685567 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TIRAP MYD88 22673208 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
FADD MYD88 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ESR1 MYD88 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 MYD88 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MYD88 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 MYD88 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MYD88 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 MYD88 12244150 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 MYD88 21030878 rna interference,inhibition western blot miRSponge
URS00004DA9DB MYD88 23522925 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB MYD88 23522925 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000338542 MYD88 21030878 22012620 25416803 mrna cleavage,inhibition western blot,clip TarBase
URS000009262D MYD88 23633945 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001C770D MYD88 24375488 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
IRAK1 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRAK1 25361965 interaction type N/A PTMCode2
IL1R1 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IL1R1 25361965 interaction type N/A PTMCode2
IRF7 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRF7 25361965 interaction type N/A PTMCode2
IRAK2 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRAK2 25361965 interaction type N/A PTMCode2
IL1RAP MYD88 25361965 interaction type N/A PTMCode2
MYD88 IL1RAP 25361965 interaction type N/A PTMCode2
IL1RL1 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IL1RL1 25361965 interaction type N/A PTMCode2
RAC1 MYD88 25361965 interaction type N/A PTMCode2
MYD88 RAC1 25361965 interaction type N/A PTMCode2
TIRAP MYD88 25361965 interaction type N/A PTMCode2
MYD88 TIRAP 25361965 interaction type N/A PTMCode2
TRAF6 MYD88 25361965 interaction type N/A PTMCode2
MYD88 TRAF6 25361965 interaction type N/A PTMCode2
STAP2 MYD88 25361965 interaction type N/A PTMCode2
MYD88 STAP2 25361965 interaction type N/A PTMCode2
IRAK4 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRAK4 25361965 interaction type N/A PTMCode2
FADD MYD88 25361965 interaction type N/A PTMCode2
MYD88 FADD 25361965 interaction type N/A PTMCode2
IRF4 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRF4 25361965 interaction type N/A PTMCode2
IRAK3 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRAK3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SPOPL MYD88 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF6 MYD88 20676093 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
TNIP1 MYD88 25348397 N/A physical interaction ComPPI
RAC1 MYD88 25348397 N/A physical interaction ComPPI
BTK MYD88 12724322 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SYK MYD88 25348397 N/A physical interaction ComPPI
PTK2B MYD88 22581261 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SIAH2 MYD88 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
CBLB MYD88 17618294 20639876 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD3 MYD88 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
USP7 MYD88 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
IRF4 MYD88 14525934 16236719 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SIAH1 MYD88 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
IL1RAP MYD88 11880380 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PFKL MYD88 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CISH MYD88 25348397 N/A physical interaction ComPPI
PRDX1 MYD88 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IKBKB MYD88 16365431 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TIRAP MYD88 11544529 17258210 17583698 21334391 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,mammalian protein protein interaction trap,in vivo ComPPI,IntAct
TRAF3 MYD88 25348397 N/A physical interaction ComPPI
TXN MYD88 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct
AGER MYD88 21829704 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
HNRNPL MYD88 25348397 N/A physical interaction ComPPI
CYTH2 MYD88 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
IRAK1 MYD88 10383454 10854325 14525934 17567694 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SQSTM1 MYD88 25348397 N/A physical interaction ComPPI
FADD MYD88 10880445 11828002 14525934 21988832 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TRAF2 MYD88 20676093 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
MDM2 MYD88 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK2 MYD88 10383454 12659850 14525934 24234451 25348397 9374458 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
HDAC6 MYD88 25348397 N/A physical interaction ComPPI
STAP2 MYD88 14525934 16365431 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
TLR2 MYD88 14525934 16293622 16482509 17126326 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
TLR4 MYD88 10952994 11743586 14525934 15728506 17126326 17258210 21829704 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MYD88 TLR3 12646618 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MYD88 IRAK3 10383454 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MYD88 IRAK4 11960013 12860405 14525934 24234451 25348397 25910212 26871637 physical association two hybrid,experimental interaction detection,light scattering,molecular sieving,nuclear magnetic resonance,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid ComPPI,HPRD,IntAct
MYD88 PELI2 12860405 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MYD88 SPOP 14525934 16189514 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
MYD88 TLR7 14525934 16482509 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MYD88 TLR8 14525934 16482509 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MYD88 FLII 14525934 16424162 19265123 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
MYD88 IL1RL1 14525934 15004556 16286016 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MYD88 TLR5 14525934 16482509 17583698 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MYD88 IRF7 14525934 15361868 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MYD88 TLR10 14525934 15728506 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
MYD88 IRF5 14525934 15665823 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MYD88 IL1R1 12659850 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MYD88 TLR9 25348397 N/A physical interaction ComPPI
MYD88 LRRFIP1 15952741 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MYD88 LRRFIP2 25348397 N/A physical interaction ComPPI
MYD88 SARM1 17258210 24234451 25348397 26592460 colocalization,physical association pull down,physical interaction,mammalian protein protein interaction trap,confocal microscopy ComPPI,IntAct
MYD88 SMAD6 25348397 N/A physical interaction ComPPI
MYD88 SMURF1 25348397 N/A physical interaction ComPPI
MYD88 BST2 25348397 N/A physical interaction ComPPI
MYD88 TNFRSF13B 20676093 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction,confocal microscopy ComPPI,IntAct
MYD88 IKBKE 25348397 N/A physical interaction ComPPI
MYD88 SASH1 25348397 N/A physical interaction ComPPI
MYD88 MBIP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MYD88 POLR1C 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
MYD88 MAL 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
MYD88 CD93 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MYD88 IKBKG 25348397 N/A physical interaction ComPPI
MYD88 CYLD 25348397 N/A physical interaction ComPPI
MYD88 DOCK8 22581261 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
MYD88 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MYD88 ZNF35 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MYD88 DMBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MYD88 RNF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CAMLG MYD88 20676093 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
PELI1 MYD88 25348397 N/A physical interaction ComPPI
MYD88 MYD88 11544529 11909531 14525934 17258210 21516116 21988832 22155231 24234451 25416956 25910212 27107012 physical association two hybrid,experimental interaction detection,mammalian protein protein interaction trap,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid HPRD,IntAct
MYD88 IRF1 17018642 27898060 N/A N/A OmniPath
MYD88 SIAH1 21988832 27898060 N/A N/A OmniPath
FADD MYD88 10880445 11606776 11828002 17785432 21131052 21988832 27898060 inhibition N/A OmniPath
TICAM2 MYD88 20072711 22685567 24265315 27898060 stimulant N/A OmniPath
MYD88 TLR8 16482509 27898060 N/A N/A OmniPath
TLR8 MYD88 16482509 19775907 27898060 stimulant N/A OmniPath
MYD88 TXN 21988832 27898060 N/A N/A OmniPath
MYD88 TRAF6 16517750 22011580 23381138 27898060 stimulant N/A OmniPath
TLR4 MYD88 10952994 11743586 12646618 12888566 15107846 15728506 17126326 17228323 17258210 17618294 17635639 18221795 18772134 19378012 19717524 19898473 20048342 21829704 21911421 27898060 9625770 stimulant N/A OmniPath
MYD88 TLR4 10952994 11743586 12646618 12888566 15107846 15728506 17126326 17228323 17258210 17618294 17635639 18221795 18772134 19378012 19717524 19898473 20048342 21829704 21911421 27898060 9625770 N/A N/A OmniPath
TLR5 MYD88 16410796 16482509 16644730 17583698 20855887 27898060 stimulant N/A OmniPath
MYD88 TLR5 16482509 16644730 17583698 20855887 27898060 N/A N/A OmniPath
MYD88 TLR10 15728506 27898060 N/A N/A OmniPath
TLR10 MYD88 15728506 27898060 stimulant N/A OmniPath
TLR2 MYD88 16293622 16482509 16798732 16893894 17126326 19717524 20348427 22673208 27898060 stimulant N/A OmniPath
MYD88 RAC1 11416133 27898060 N/A N/A OmniPath
MYD88 BTK 12724322 27898060 N/A N/A OmniPath
MYD88 TLR9 12791976 15107846 17417641 21911421 27898060 N/A N/A OmniPath
TLR9 MYD88 12791976 15107846 16410796 17417641 21911421 27898060 stimulant N/A OmniPath
IRF5 MYD88 15665823 16236719 17018642 27898060 N/A N/A OmniPath
MYD88 IRF5 15665823 16236719 17018642 27898060 N/A N/A OmniPath
MYD88 IRF3 21248248 27898060 N/A N/A OmniPath
MYD88 PIK3R1 16644730 27898060 N/A N/A OmniPath
MYD88 IRF7 15361868 16484229 17018642 18924132 27898060 N/A N/A OmniPath
IL1R1 MYD88 10217414 10854325 12609980 12659850 15866876 15905496 16286016 16354686 17507369 19940113 22904187 24735611 27898060 9374458 9430229 9575168 stimulant N/A OmniPath
MYD88 IL1R1 10217414 10854325 12609980 12659850 15866876 15905496 16286016 16354686 17507369 19940113 22904187 24735611 27898060 9374458 9430229 9575168 inhibition N/A OmniPath
MYD88 USP7 21988832 27898060 N/A N/A OmniPath
MYD88 TLR3 12646618 27898060 N/A N/A OmniPath
MYD88 TLR7 12791976 16482509 21988832 27898060 N/A N/A OmniPath
TLR7 MYD88 12791976 16410796 16482509 21988832 27898060 stimulant N/A OmniPath
TIRAP MYD88 11526399 11544529 12888566 16410796 17258210 17583698 18221795 19506249 20048342 21334391 21873236 22673208 24265315 25948473 27898060 stimulant N/A OmniPath
IRAK1 MYD88 10217414 10383454 10811644 10854325 11544529 11960013 11976320 12034707 12360211 12538665 16024789 16461741 16951367 16951688 17228323 17276401 17510469 17548806 17567694 17785432 17920759 18524972 19679662 21179087 21743479 21903422 22011580 27898060 9430229 N/A N/A OmniPath
MYD88 IRAK1 10217414 10383454 10811644 10854325 11544529 11960013 11976320 12034707 12360211 12538665 16024789 16461741 16951367 16951688 17228323 17276401 17510469 17548806 17567694 17785432 17920759 18524972 19679662 19775907 21179087 21743479 21903422 22011580 27898060 9430229 stimulant N/A OmniPath
MYD88 IRAK4 11960013 12150927 12297423 12538665 12860405 15084582 15905496 16410796 17486091 17548806 18221795 19167362 19592493 19679662 20485341 20966070 21179087 22011580 24735611 25416956 27898060 stimulant N/A OmniPath
IRAK4 MYD88 11960013 12150927 12538665 12860405 15084582 15905496 17486091 17548806 18221795 19167362 19592493 19679662 20485341 20966070 21179087 22011580 24735611 25416956 27898060 N/A N/A OmniPath
MYD88 SMAD3 21988832 27898060 N/A N/A OmniPath
MYD88 IL1RAP 11880380 13679373 15849357 27898060 9374458 inhibition N/A OmniPath
TNFRSF13B MYD88 20676093 27898060 N/A N/A OmniPath
MYD88 LRRFIP2 21220426 27898060 N/A N/A OmniPath
IRF4 MYD88 16236719 18188453 24670424 27898060 N/A N/A OmniPath
MYD88 TRIP6 15657077 27898060 N/A N/A OmniPath
MYD88 IRAK3 10383454 12150927 27898060 N/A N/A OmniPath
IRAK3 MYD88 10383454 12150927 27898060 N/A N/A OmniPath
STAP2 MYD88 16365431 27898060 N/A N/A OmniPath
MYD88 TLR6 19717524 27898060 N/A N/A OmniPath
MYD88 SYK 17228323 27898060 N/A N/A OmniPath
PELI1 MYD88 16951688 27898060 N/A N/A OmniPath
MYD88 PELI1 16951688 27898060 N/A N/A OmniPath
MYD88 IRAK2 10383454 12659850 20485341 22011580 27898060 9374458 N/A N/A OmniPath
MAL MYD88 21988832 22485159 27898060 stimulant N/A OmniPath
MYD88 TLR1 19717524 22673208 27898060 N/A N/A OmniPath
MYD88 SPOP 16189514 21988832 26186194 27898060 N/A N/A OmniPath
SIGIRR MYD88 15866876 20364327 27898060 inhibition N/A OmniPath
MYD88 SIGIRR 15866876 20364327 27898060 N/A N/A OmniPath

Visualization










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