GENE：NECTIN1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NECTIN1 |
| FullNmae | nectin cell adhesion molecule 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9706 |
| EnsembleID | ENSG00000110400 |
| Uniprot | Q15223 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NECTIN1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NECTIN1 | GO:0001618,GO:0002089,GO:0002934,GO:0005515,GO:0005576,GO:0005886,GO:0005912,GO:0005912,GO:0005912,GO:0006826,GO:0006955,GO:0007155,GO:0007156,GO:0007156,GO:0007157,GO:0007157,GO:0007411,GO:0015026,GO:0016020,GO:0030246,GO:0030425,GO:0032584,GO:0042802,GO:0042803,GO:0043296,GO:0044291,GO:0044877,GO:0046718,GO:0046790,GO:0048787,GO:0050839,GO:0051963,GO:0060041,GO:0070166,GO:0098609,GO:0098686,GO:1902414 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NECTIN1 | hsa:5818 | path:hsa03266 | Virion - Herpesvirus - Homo sapiens (human) |
| NECTIN1 | hsa:5818 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
| NECTIN1 | hsa:5818 | path:hsa04520 | Adherens junction - Homo sapiens (human) |
| NECTIN1 | hsa:5818 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | NECTIN1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| GATA2 | NECTIN1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | NECTIN1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | NECTIN1 | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | NECTIN1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | NECTIN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003D5391 | NECTIN1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001C770D | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002367FA | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000014F13C | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BE495 | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000045ED38 | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000027F5F3 | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000759B6A | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CE046 | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000334286 | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C403E | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077DDE | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EC1BE | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000235862 | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | NECTIN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PICK1 | NECTIN1 | 24234451 25348397 26787460 | physical association | two hybrid | ComPPI,IntAct |
| SOCS1 | NECTIN1 | 25348397 | N/A | physical interaction | ComPPI |
| FGFR2 | NECTIN1 | 25348397 | N/A | physical interaction | ComPPI |
| CDH1 | NECTIN1 | 25348397 | N/A | physical interaction | ComPPI |
| PRNP | NECTIN1 | 14525934 15146195 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PVR | NECTIN1 | 22902367 24234451 25348397 | N/A | surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array | ComPPI,IntAct |
| NECTIN1 | PKHD1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| NECTIN1 | PARD3 | 12515806 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| NECTIN1 | NECTIN3 | 12011057 14525934 21982860 24234451 25348397 | physical association | cosedimentation in solution,experimental interaction detection,fluorescence-activated cell sorting,protein array,physical interaction,in vitro,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| NECTIN1 | NECTIN4 | 12011057 14525934 21982860 22902367 24234451 25348397 | physical association | cosedimentation in solution,experimental interaction detection,fluorescence-activated cell sorting,protein array,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| NECTIN1 | AFDN | 10225955 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| NECTIN1 | LGALS8 | 25348397 | N/A | physical interaction | ComPPI |
| NECTIN1 | FGFR1 | 25348397 | N/A | physical interaction | ComPPI |
| NECTIN1 | FGFR3 | 25348397 | N/A | physical interaction | ComPPI |
| NECTIN1 | SDCBP | 24234451 25348397 26787460 | colocalization,physical association | anti bait coimmunoprecipitation,two hybrid,phage display,surface plasmon resonance,fluorescence microscopy | ComPPI,IntAct |
| NECTIN1 | GRIP2 | 24234451 25348397 26787460 | physical association | two hybrid | ComPPI,IntAct |
| NECTIN1 | NECTIN1 | 12011057 14525934 21982860 22902367 24234451 | physical association | cosedimentation in solution,experimental interaction detection,fluorescence-activated cell sorting,protein array,surface plasmon resonance,x-ray crystallography | HPRD,IntAct |
| AFDN | NECTIN1 | 10225955 10617658 15811349 27898060 | N/A | N/A | OmniPath |
| NECTIN1 | NECTIN4 | 12011057 21982860 22902367 27898060 | N/A | N/A | OmniPath |
| NECTIN4 | NECTIN1 | 12011057 21982860 22902367 27898060 | N/A | N/A | OmniPath |
| NECTIN1 | CD96 | 24658051 27898060 | N/A | N/A | OmniPath |