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GENE：NELFE

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NELFE
FullNmae negative elongation factor complex member E
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13974
EnsembleID ENSG00000204356
Uniprot P18615

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NELFE immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NELFE GO:0000122,GO:0000785,GO:0003682,GO:0003723,GO:0003723,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005886,GO:0016604,GO:0032021,GO:0032021,GO:0032021,GO:0034244,GO:0034244,GO:0045944,GO:0051179,GO:0051571,GO:0070374

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NELFE hsa:7936 path:hsa03250 Viral life cycle - HIV-1 - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SRPK2 NELFE 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 NELFE 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 NELFE 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NELFE 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF NELFE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NELFE 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 NELFE 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D NELFE 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004B83FE NELFE 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000058878F NELFE 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 NELFE 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 NELFE 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AURKB NELFE 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
LMNA NELFE 25348397 N/A physical interaction ComPPI
YWHAG NELFE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HSP90AB1 NELFE 22579285 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
NELFB NELFE 12612062 14667819 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,IntAct
SF3B1 NELFE 25348397 N/A physical interaction ComPPI
PSMA3 NELFE 25348397 N/A physical interaction ComPPI
NCOR1 NELFE 14525934 14667819 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
NTRK1 NELFE 25348397 N/A physical interaction ComPPI
PSMA1 NELFE 25348397 N/A physical interaction ComPPI
PSMA6 NELFE 25348397 N/A physical interaction ComPPI
PSMA5 NELFE 25348397 N/A physical interaction ComPPI
NELFCD NELFE 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
FECH NELFE 25348397 N/A physical interaction ComPPI
SRPK1 NELFE 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
VAMP3 NELFE 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLR2A NELFE 25348397 N/A physical interaction ComPPI
NCBP1 NELFE 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCBP2 NELFE 24234451 25348397 26382858 26496610 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
IGHMBP2 NELFE 25348397 N/A physical interaction ComPPI
SRPK2 NELFE 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
TRIM27 NELFE 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMB4 NELFE 25348397 N/A physical interaction ComPPI
DIS3 NELFE 25348397 N/A physical interaction ComPPI
POLR2C NELFE 18562274 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NELFA NELFE 12612062 24234451 25348397 26496610 colocalization,association anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
RSRC1 NELFE 25348397 N/A physical interaction ComPPI
MTUS2 NELFE 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NELFE CACTIN 25348397 N/A physical interaction ComPPI
NELFE WDR48 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NELFE RPAP2 25348397 N/A physical interaction ComPPI
NELFE TMEM141 25348397 N/A physical interaction ComPPI
NELFE CCDC57 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NELFE TTC29 25348397 N/A physical interaction ComPPI
NELFE PSMB6 25348397 N/A physical interaction ComPPI
NELFE PYM1 25348397 N/A physical interaction ComPPI
NELFE NELFE 10199401 12612062 14525934 N/A experimental interaction detection HPRD

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