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GENE：NR1I2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NR1I2
FullNmae nuclear receptor subfamily 1 group I member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7968
EnsembleID ENSG00000144852
Uniprot O75469

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NR1I2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NR1I2 GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0004879,GO:0004879,GO:0005515,GO:0005654,GO:0005654,GO:0005667,GO:0006355,GO:0006805,GO:0007165,GO:0008202,GO:0008270,GO:0010628,GO:0016604,GO:0016922,GO:0030154,GO:0030522,GO:0042178,GO:0042908,GO:0045111,GO:0045892,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:1990837

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NR1I2 NLRP3 23180781 25202020 physical association anti tag coimmunoprecipitation InnateDB
NR1I2 SLC13A5 23180781 25628225 physical association anti tag coimmunoprecipitation InnateDB
RXRA NR1I2 10908304 23331499 stimulation N/A SignaLink
NR0B2 NR1I2 12805410 23331499 stimulation N/A SignaLink
NR1I2 HNF4A 15331348 23331499 stimulation N/A SignaLink
NR1I2 RXRA 11706036 15604093 23331499 9489701 9727070 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR NR1I2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 NR1I2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NR1I2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HNF4A NR1I2 12601364 18305375 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
TP73 NR1I2 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NR1I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NR1I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NR1I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NR1I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NR1I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR NR1I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NR1I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DR1 NR1I2 18305375 trascriptional regulation,stimulation inferred by curator TFlink
NCOR2 NR1I2 16219912 trascriptional regulation,stimulation inferred by curator TFlink
NR1H4 NR1I2 21476904 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 NR1I2 12815172 trascriptional regulation,stimulation inferred by curator TFlink
PROX1 NR1I2 22023334 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003BBF48 NR1I2 18268015 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00003BBF48 NR1I2 18268015 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003D5391 NR1I2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000019907A NR1I2 25416803 27085140 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000035CC3E NR1I2 25416803 28408657 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 NR1I2 22135298 phosphorylation N/A PhosphoSite
PRKCA NR1I2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2I NR1I2 25348397 N/A physical interaction ComPPI
RXRG NR1I2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
HSP90AB1 NR1I2 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
SRC NR1I2 12072427 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
POU1F1 NR1I2 11891224 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NCOA3 NR1I2 14525934 16219912 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NCOA1 NR1I2 12072427 12909012 14525934 15604093 19171678 23160820 23602807 24234451 25348397 27898060 physical association experimental interaction detection,fluorescence polarization spectroscopy,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
NCOR2 NR1I2 12072427 16144941 16219912 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
NCOR1 NR1I2 25348397 N/A physical interaction ComPPI
PPARGC1A NR1I2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
HSP90AA1 NR1I2 25348397 N/A physical interaction ComPPI
NR1I2 RXRB 14525934 15604093 25348397 9727070 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
NR1I2 PSMC5 14525934 14702340 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
NR1I2 ACTN2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NR1I2 NUCB2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NR1I2 PRMT1 25348397 N/A physical interaction ComPPI
NR1I2 TADA3 25348397 N/A physical interaction ComPPI
NR1I2 CHMP1A 25348397 N/A physical interaction ComPPI
NR1I2 RXRA 14525934 15604093 25348397 9489701 9727070 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
NR1I2 NCOA6 25348397 N/A physical interaction ComPPI
NR1I2 NCOA2 25348397 N/A physical interaction ComPPI
NR1I2 RBCK1 25348397 N/A physical interaction ComPPI
NR1I2 HSP90AA2P 25348397 N/A physical interaction ComPPI
NR1I2 ATP6AP1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR1I2 FGR 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR1I2 SDF4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR1I2 NFATC4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR1I2 MAPK7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR1I2 TFAP2C 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR1I2 UBR5 25348397 N/A physical interaction ComPPI
NR1I2 DDB1 25348397 N/A physical interaction ComPPI
NR1I2 RBBP7 25348397 N/A physical interaction ComPPI
NR1I2 DYRK2 25348397 N/A physical interaction ComPPI
NR1I2 RPS6KB1 25348397 N/A physical interaction ComPPI
NR1I2 DNMT3L 25348397 N/A physical interaction ComPPI
NR1I2 TP53 25348397 N/A physical interaction ComPPI
NR1I2 CEBPA 25348397 N/A physical interaction ComPPI
NR1I2 HNF4A 25348397 N/A physical interaction ComPPI
NR1I2 NR0B2 25348397 N/A physical interaction ComPPI
NR1I2 NR5A2 25348397 N/A physical interaction ComPPI
NR1I2 NR1I2 12909012 14525934 N/A experimental interaction detection HPRD
TCERG1 NR1I2 24234451 30021884 physical association cross-linking study IntAct
CDK2 NR1I2 18784074 19617467 22829544 23264496 24184507 26119819 27898060 inhibition N/A OmniPath
NR1I2 FOXO1 17684529 27898060 stimulant N/A OmniPath
FOXO1 NR1I2 17684529 27898060 stimulant N/A OmniPath
NR1I2 RXRA 10908304 11706036 15604093 23160820 27898060 9489701 9727070 stimulant N/A OmniPath
RXRA NR1I2 10908304 11706036 15604093 23160820 27898060 9489701 9727070 stimulant N/A OmniPath
NR0B2 NR1I2 12805410 27898060 inhibition,stimulant N/A OmniPath
NR1I2 HNF4A 15331348 27898060 stimulant N/A OmniPath

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