Gene Information gene info

  1. Home

GENE：NR4A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NR4A1
FullNmae nuclear receptor subfamily 4 group A member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7980
EnsembleID ENSG00000123358
Uniprot P22736

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NR4A1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NR4A1 GO:0000785,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001228,GO:0001530,GO:0001938,GO:0001975,GO:0002042,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005739,GO:0005829,GO:0006357,GO:0006366,GO:0006915,GO:0006954,GO:0007165,GO:0008270,GO:0014860,GO:0030522,GO:0031965,GO:0032497,GO:0035259,GO:0035767,GO:0035914,GO:0035924,GO:0042802,GO:0043065,GO:0044344,GO:0045444,GO:0045786,GO:0045944,GO:0046982,GO:0051602,GO:0061469,GO:0071376,GO:0071376,GO:0098793,GO:0160075,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NR4A1 hsa:3164 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
NR4A1 hsa:3164 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
NR4A1 hsa:3164 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
NR4A1 hsa:3164 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
NR4A1 hsa:3164 path:hsa04934 Cushing syndrome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NR4A1 EGR1 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
GK NR4A1 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
NR4A1 STAT3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
NR4A1 NR2F2 23331499 9130711 stimulation N/A SignaLink,SignaLink
RXRA NR4A1 10772826 14980220 23331499 stimulation N/A SignaLink
RARA NR4A1 10772826 23331499 stimulation N/A SignaLink
NR0B1 NR4A1 15155786 23331499 stimulation N/A SignaLink
NR3C1 NR4A1 15591535 21900206 23331499 stimulation N/A SignaLink
NR4A1 NR3C1 15591535 23331499 stimulation N/A SignaLink
NR4A1 NR2F1 23331499 9130711 stimulation N/A SignaLink
NR4A1 NR4A2 12529383 23331499 stimulation N/A SignaLink
NR4A2 NR4A1 12529383 23331499 stimulation N/A SignaLink
NR4A1 NR4A3 12529383 23331499 stimulation N/A SignaLink
NR4A3 NR4A1 12529383 23331499 stimulation N/A SignaLink
CTNNB1 NR4A1 21362399 21986938 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
YWHAZ NR4A1 20005715 interaction type N/A PSP
YWHAZ NR4A1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 NR4A1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NR4A1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RELA NR4A1 20018891 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 NR4A1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NR4A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NR4A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NR4A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NR4A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NR4A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NR4A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC7 NR4A1 15623513 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 NR4A1 15623513 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A NR4A1 14729605 trascriptional regulation,stimulation inferred by curator TFlink
MEF2C NR4A1 18079734 trascriptional regulation,stimulation inferred by curator TFlink
PML NR4A1 12032831 trascriptional regulation,stimulation inferred by curator TFlink
SP1 NR4A1 8961265 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 NR4A1 8961265 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 NR4A1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000A07C1 NR4A1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 NR4A1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 NR4A1 22135298 phosphorylation N/A PhosphoSite
MAPK1 NR4A1 22135298 phosphorylation N/A PhosphoSite
MAPK8 NR4A1 22135298 phosphorylation N/A PhosphoSite
AKT1 NR4A1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PGBD1 NR4A1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMARCE1 NR4A1 25348397 N/A physical interaction ComPPI
KRTAP10-5 NR4A1 24234451 25348397 25416956 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-1 NR4A1 25348397 N/A physical interaction ComPPI
VASP NR4A1 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
SMARCC1 NR4A1 25348397 N/A physical interaction ComPPI
FABP3 NR4A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
RXRG NR4A1 12082103 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDKN2D NR4A1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ATXN1 NR4A1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HSP90AB1 NR4A1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK1 NR4A1 11883936 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CD2AP NR4A1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RNF111 NR4A1 25348397 N/A physical interaction ComPPI
MAPK8 NR4A1 25348397 N/A physical interaction ComPPI
SMAD7 NR4A1 25348397 N/A physical interaction ComPPI
MPDZ NR4A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NCOA3 NR4A1 12082103 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NCOA1 NR4A1 12082103 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EP300 NR4A1 12082103 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
SMAD3 NR4A1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HIF1A NR4A1 14525934 18305400 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MYBBP1A NR4A1 25348397 N/A physical interaction ComPPI
MAPK14 NR4A1 25348397 N/A anti tag coimmunoprecipitation,pull down,phosphorylation reaction,physical interaction,protein kinase assay ComPPI
KAT2B NR4A1 12082103 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CLU NR4A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NCOR2 NR4A1 11559707 16002533 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
MED1 NR4A1 12082103 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
YWHAZ NR4A1 14525934 16223362 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPM1A NR4A1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FAF1 NR4A1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRMT1 NR4A1 19095693 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
SERPING1 NR4A1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AXIN2 NR4A1 25348397 N/A physical interaction ComPPI
HSP90B1 NR4A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRDX4 NR4A1 21900206 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PELP1 NR4A1 25348397 N/A physical interaction ComPPI
EEF1A1 NR4A1 25348397 N/A physical interaction ComPPI
RPS6KA3 NR4A1 14525934 16223362 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPARG NR4A1 25348397 N/A physical interaction ComPPI
RPS6KA1 NR4A1 14525934 16223362 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NDRG1 NR4A1 25348397 N/A physical interaction ComPPI
RELA NR4A1 25348397 N/A anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
ERC1 NR4A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ATM NR4A1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GRK6 NR4A1 25348397 N/A physical interaction ComPPI
XPO1 NR4A1 25348397 N/A physical interaction ComPPI
PSMC5 NR4A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NCOA2 NR4A1 12082103 14525934 19095693 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
RLIM NR4A1 25348397 N/A physical interaction ComPPI
HNRNPA2B1 NR4A1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VHL NR4A1 14525934 18305400 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NR4A1 RPS6KA5 14525934 16223362 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
NR4A1 PML 12032831 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NR4A1 RPS6KA6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NR4A1 FXYD3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NR4A1 ARHGEF10L 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NR4A1 GADD45GIP1 14525934 15459248 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
NR4A1 BCL2L10 14525934 18835031 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
NR4A1 BCL2A1 14525934 18835031 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
NR4A1 BCL2 14525934 14980220 18835031 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,circular dichroism,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NR4A1 AKT1 11274386 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NR4A1 RXRA 25348397 N/A physical interaction ComPPI
NR4A1 TP53 14525934 17139261 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
NR4A1 CHD4 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
NR4A1 TOP2A 25348397 N/A physical interaction ComPPI
NR4A1 MTA2 25348397 N/A physical interaction ComPPI
NR4A1 TRIM28 25348397 N/A physical interaction ComPPI
NR4A1 TMOD3 25348397 N/A physical interaction ComPPI
NR4A1 EEF1A1P5 25348397 N/A physical interaction ComPPI
NR4A1 HDAC6 25348397 N/A physical interaction ComPPI
NR4A1 POLA2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ROBO2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 NR3C1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ZNF579 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 MED31 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 RPL7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 RTN4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 BBS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 NACAD 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ZNF331 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 GLOD4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 TCF4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 CHD3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 SERPINA4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 PPBP 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 CTNNB1 25348397 N/A physical interaction ComPPI
NR4A1 MAP3K1 25348397 N/A physical interaction ComPPI
NR4A1 STAT3 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
NR4A1 CHEK2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 DIABLO 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 SUGT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 RBL1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ABCC6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 CPT1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 GK 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
NR4A1 GLUD1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 HADHA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 LSS 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 NFKB1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ARHGEF5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ABCB11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 CHD1L 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 PRDX6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ABCA5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 ABCG8 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 SOCS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 TUBB4A 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
NR4A1 CUTA 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
NR4A1 ANKIB1 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
NR4A1 LONRF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NR4A1 MIDN 25348397 N/A physical interaction ComPPI
NR4A1 ACAD11 25348397 N/A physical interaction ComPPI
NR4A1 TMTC4 25348397 N/A physical interaction ComPPI
NR4A1 PCK1 25348397 N/A physical interaction ComPPI
NR4A1 BNIP3L 24234451 24316735 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
NR4A1 SLC25A4 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
NR4A1 STK11 25348397 N/A pull down,physical interaction ComPPI
NR4A1 ESF1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 MATR3 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 MYT1L 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 CHMP2B 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 PCDHGC3 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 PHIP 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 TERF1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 HSPH1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 DCAF1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 PREPL 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 CENPB 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 SEPTIN4 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A1 PLXND1 24139859 24234451 25348397 27898060 physical association two hybrid,pull down ComPPI,IntAct,OmniPath
NR4A1 NR4A1 12082103 14525934 N/A experimental interaction detection HPRD
CTNNB1 NR4A1 21362399 2198694 27898060 stimulant N/A OmniPath
RPS6KA5 NR4A1 11274386 16223362 18669648 25241761 27898060 N/A N/A OmniPath
MAPK9 NR4A1 11274386 27898060 N/A N/A OmniPath
RPS6KA1 NR4A1 11274386 16223362 18669648 27898060 stimulant N/A OmniPath
MAPK7 NR4A1 18429814 27898060 stimulant N/A OmniPath
AKT1 NR4A1 11274386 18669648 27898060 inhibition N/A OmniPath
RARA NR4A1 10772826 27898060 stimulant N/A OmniPath
RXRA NR4A1 10772826 1498022 14980220 17761950 27898060 7705655 stimulant N/A OmniPath
RPS6KA3 NR4A1 11274386 16223362 18669648 27898060 N/A N/A OmniPath
MAPK1 NR4A1 11883936 22002310 27898060 N/A N/A OmniPath
CSNK2A1 NR4A1 22789442 27898060 N/A N/A OmniPath
NR4A1 STAT3 21988832 27898060 N/A N/A OmniPath
MAPK8 NR4A1 14612408 17023523 27898060 inhibition N/A OmniPath
NR3C1 NR4A1 15591535 21900206 2190021 27898060 stimulant N/A OmniPath
NR4A1 NR3C1 15591535 21900206 2190021 27898060 stimulant N/A OmniPath
GK NR4A1 21988832 27898060 N/A N/A OmniPath
NR4A1 NR2F2 27898060 9130711 stimulant N/A OmniPath

Visualization










  Return