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GENE：PDCD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDCD1
FullNmae programmed cell death 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8760
EnsembleID ENSG00000188389
Uniprot Q15116

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDCD1 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature

Go Annotation:

GeneSymbol Go id
PDCD1 GO:0001783,GO:0002250,GO:0002644,GO:0002903,GO:0005515,GO:0005886,GO:0006915,GO:0006959,GO:0009897,GO:0050776,GO:0050777,GO:0070234,GO:0070234,GO:1902482

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDCD1 hsa:5133 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
PDCD1 hsa:5133 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PDCD1 hsa:5133 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTPN11 PDCD1 10358138 11447289 11572860 12138178 12176909 12707331 12773515 12917349 15240681 15699106 15713798 17371980 19833085 22437870 22513334 22952938 23732914 25355530 26192618 26667266 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283 interaction type N/A ACSN
PTPN6 PDCD1 10358138 11447289 11572860 12138178 12176909 12707331 12773515 12917349 15240681 15699106 15713798 17371980 19833085 22437870 22513334 22952938 23732914 25355530 26192618 26667266 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283 interaction type N/A ACSN
TBX21 PDCD1 10761931 12055627 12802010 14614857 15084276 16410834 17440449 18768831 26192618 26885856 interaction type N/A ACSN
FOXO1 PDCD1 15668399 19449109 25464856 26192618 interaction type N/A ACSN
STAT1 PDCD1 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 26192618 8683106 interaction type N/A ACSN
STAT2 PDCD1 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 26192618 8683106 interaction type N/A ACSN
ADORA2A PDCD1 17371980 17909080 18758473 26192618 interaction type N/A ACSN
CD274 PDCD1 11015443 12893276 18841514 23180781 physical association surface plasmon resonance,solid phase assay InnateDB
PDCD1LG2 PDCD1 12893276 23180781 physical association surface plasmon resonance InnateDB
SOCS1 PDCD1 21263070 23180781 physical association anti tag coimmunoprecipitation InnateDB
PDCD1 CD274 21422170 23180781 physical association x-ray crystallography InnateDB
PDCD1 PTPN6 11160222 15240681 15358536 23109003 chemical activation reaction N/A SignaLink
PDCD1 PTPN11 11160222 15240681 15358536 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SMARCA4 PDCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 PDCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000040EE1D PDCD1 21572407 22927820 24906430 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000041CB9C PDCD1 21572407 22927820 24906430 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00000F0F49 PDCD1 21572407 22927820 24906430 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000171CD1 PDCD1 21572407 22927820 24906430 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000007D64A PDCD1 21572407 22927820 24906430 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 PDCD1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PDCD1 CD274 25361965 interaction type N/A PTMCode2
CD274 PDCD1 25361965 interaction type N/A PTMCode2
PDCD1 PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 PDCD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PTPN6 PDCD1 15240681 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
SLC25A6 PDCD1 25348397 N/A physical interaction ComPPI
PTPN9 PDCD1 25348397 N/A physical interaction ComPPI
SOCS1 PDCD1 25348397 N/A physical interaction ComPPI
PTPN11 PDCD1 15240681 24234451 25348397 28046066 colocalization,association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
ARF6 PDCD1 25348397 N/A physical interaction ComPPI
DAD1 PDCD1 25348397 N/A physical interaction ComPPI
CD274 PDCD1 12719480 12893276 14525934 20587542 21982860 23417675 24234451 25348397 physical association experimental interaction detection,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,protein array,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
PDCD1 PDCD1LG2 20587542 23417675 24234451 25348397 physical association isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,physical interaction ComPPI,IntAct
PDCD1 RAB5IF 25348397 N/A physical interaction ComPPI
PDCD1 POP5 25348397 N/A physical interaction ComPPI
PDCD1 SFXN3 25348397 N/A physical interaction ComPPI
PDCD1 SLC25A23 25348397 N/A physical interaction ComPPI
PDCD1 DAGLB 25348397 N/A physical interaction ComPPI
PDCD1 SMDT1 25348397 N/A physical interaction ComPPI
PDCD1 RHBDF2 25348397 N/A physical interaction ComPPI
PDCD1 DENND6A 25348397 N/A physical interaction ComPPI
PDCD1 SLC25A28 25348397 N/A physical interaction ComPPI
PDCD1 INTS4 25348397 N/A physical interaction ComPPI
PDCD1 INTS7 25348397 N/A physical interaction ComPPI
PDCD1 SLC25A16 25348397 N/A physical interaction ComPPI
PDCD1 DCP2 25348397 N/A physical interaction ComPPI
PDCD1 PNPLA6 25348397 N/A physical interaction ComPPI
PDCD1 WDFY3 25348397 N/A physical interaction ComPPI
PDCD1 NOCT 25348397 N/A physical interaction ComPPI
PDCD1 SLC25A46 25348397 N/A physical interaction ComPPI
PDCD1 ACP2 25348397 N/A physical interaction ComPPI
PDCD1 TMEM223 25348397 N/A physical interaction ComPPI
PDCD1 XPR1 25348397 N/A physical interaction ComPPI
PDCD1 SH3BP4 25348397 N/A physical interaction ComPPI
PDCD1 NAV1 25348397 N/A physical interaction ComPPI
PDCD1 SLC25A15 25348397 N/A physical interaction ComPPI
PDCD1 SPPL3 25348397 N/A physical interaction ComPPI
PDCD1 GALNT11 25348397 N/A physical interaction ComPPI
PDCD1 CHPT1 25348397 N/A physical interaction ComPPI
PDCD1 RPTOR 25348397 N/A physical interaction ComPPI
PDCD1 TUBGCP4 25348397 N/A physical interaction ComPPI
PDCD1 ARL5B 25348397 N/A physical interaction ComPPI
PDCD1 GK 25348397 N/A physical interaction ComPPI
PDCD1 TMEM126B 25348397 N/A physical interaction ComPPI
PDCD1 MCU 25348397 N/A physical interaction ComPPI
PDCD1 ARFGEF2 25348397 N/A physical interaction ComPPI
PDCD1 BMPR1A 25348397 N/A physical interaction ComPPI
PDCD1 HEATR6 25348397 N/A physical interaction ComPPI
PDCD1 LGR4 25348397 N/A physical interaction ComPPI
PDCD1 SLC26A6 25348397 N/A physical interaction ComPPI
PDCD1 RTEL1 25348397 N/A physical interaction ComPPI
PDCD1 TMEM184B 25348397 N/A physical interaction ComPPI
PDCD1 AGO1 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PDCD1 DMBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDCD1 CD80 20587542 24234451 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
XPO7 PDCD1 25348397 N/A physical interaction ComPPI
RTL8C PDCD1 25348397 N/A physical interaction ComPPI
FAM3C PDCD1 25348397 N/A physical interaction ComPPI
PDCD1 SOCS1 21263070 27898060 N/A N/A OmniPath
PAX5 PDCD1 15676205 27898060 inhibition N/A OmniPath
CD274 PDCD1 11015443 12719480 12893276 18841514 21422170 21982860 26602187 27898060 stimulant N/A OmniPath
PDCD1LG2 PDCD1 12893276 23954143 27898060 stimulant N/A OmniPath

Visualization










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