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GENE：PECAM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PECAM1
FullNmae platelet and endothelial cell adhesion molecule 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8823
EnsembleID ENSG00000261371
Uniprot P16284

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PECAM1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PECAM1 GO:0001934,GO:0004888,GO:0005515,GO:0005615,GO:0005886,GO:0005886,GO:0005911,GO:0006909,GO:0007156,GO:0007159,GO:0007165,GO:0007166,GO:0008037,GO:0030335,GO:0030667,GO:0031092,GO:0032991,GO:0035633,GO:0035696,GO:0042803,GO:0045121,GO:0050731,GO:0050904,GO:0061028,GO:0070062,GO:0070830,GO:0072011,GO:0072672,GO:0098609,GO:0098742,GO:0098742,GO:0150107

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PECAM1 hsa:5175 path:hsa04148 Efferocytosis - Homo sapiens (human)
PECAM1 hsa:5175 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
PECAM1 hsa:5175 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PECAM1 hsa:5175 path:hsa05144 Malaria - Homo sapiens (human)
PECAM1 hsa:5175 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PECAM1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PECAM1 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PECAM1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PECAM1 19941826 9028949 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
YBX1 PECAM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 PECAM1 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 PECAM1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PECAM1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
LCK PECAM1 22135298 phosphorylation N/A PhosphoSite
FYN PECAM1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
YES1 PECAM1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
VIM PECAM1 10801826 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PPP2R1A PECAM1 25348397 N/A physical interaction ComPPI
PTPN6 PECAM1 24234451 25348397 9774457 association pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,IntAct
MAPK1 PECAM1 25348397 N/A physical interaction ComPPI
PECAM1 CD38 25348397 N/A in vitro ComPPI
PECAM1 LYN 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PECAM1 PIK3R1 25348397 27898060 9774384 N/A physical interaction,in vitro ComPPI,OmniPath
PECAM1 ITGB3 25348397 N/A physical interaction,in vivo ComPPI
PECAM1 PTPN11 10350061 10704309 10801826 24234451 25348397 27898060 9054388 9312087 9774457 association lambda phage display,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,IntAct,OmniPath
PECAM1 PRKCE 10801826 24234451 25348397 N/A protein kinase assay,in vitro ComPPI,IntAct
PECAM1 SRC 10801826 24234451 25348397 9162084 association pull down,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,IntAct
PECAM1 INPP5D 25348397 N/A physical interaction,in vitro ComPPI
PECAM1 CTNNB1 10801826 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
PECAM1 EFNB2 16357318 25348397 27898060 N/A in vivo ComPPI,OmniPath
PECAM1 CSK 25348397 N/A physical interaction,in vitro ComPPI
PECAM1 XRCC6 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PECAM1 DSP 10801826 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct
PECAM1 ITGA5 25348397 N/A in vivo ComPPI
PECAM1 FYN 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PECAM1 HCK 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PECAM1 LCK 25348397 N/A physical interaction,in vitro ComPPI
PECAM1 PLCG1 25348397 N/A physical interaction ComPPI
PECAM1 LGALS1 25348397 N/A physical interaction ComPPI
PECAM1 ABL2 23322602 24234451 25348397 association pull down ComPPI,IntAct
PECAM1 SH2D1B 23322602 24234451 25348397 association pull down ComPPI,IntAct
PECAM1 GNAQ 24234451 24497640 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PECAM1 ACKR3 24234451 24497640 25348397 physical association proximity ligation assay ComPPI,IntAct
PECAM1 SDC1 24234451 24497640 25348397 physical association proximity ligation assay ComPPI,IntAct
PECAM1 GPC1 24234451 24497640 25348397 physical association proximity ligation assay ComPPI,IntAct
PECAM1 CXCR4 24234451 24497640 25348397 physical association proximity ligation assay ComPPI,IntAct
PECAM1 SDC4 24234451 24497640 25348397 physical association proximity ligation assay ComPPI,IntAct
JUP PECAM1 10801826 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct
PRPF40A PECAM1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FYN PECAM1 10704309 10858437 11927609 12207897 12535670 15201144 18182571 27898060 9312087 N/A N/A OmniPath
ABL2 PECAM1 15201144 15766557 27898060 N/A N/A OmniPath
PTPN6 PECAM1 10350061 27898060 9774457 N/A N/A OmniPath
FER PECAM1 15592455 18083107 18088087 19342684 19690332 27898060 9298995 N/A N/A OmniPath

Visualization










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