GENE：PFKFB3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PFKFB3 |
| FullNmae | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8874 |
| EnsembleID | ENSG00000170525 |
| Uniprot | Q16875 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PFKFB3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PFKFB3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PFKFB3 | GO:0003873,GO:0003873,GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005829,GO:0006000,GO:0006003,GO:0046835 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PFKFB3 | hsa:5209 | path:hsa00051 | Fructose and mannose metabolism - Homo sapiens (human) |
| PFKFB3 | hsa:5209 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PFKFB3 | hsa:5209 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| PFKFB3 | hsa:5209 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | PFKFB3 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | PFKFB3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | PFKFB3 | 16025159 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| SMARCA4 | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PFKFB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | PFKFB3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PGR | PFKFB3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | PFKFB3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | PFKFB3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000007A060 | PFKFB3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000075A760 | PFKFB3 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | PFKFB3 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000047E28E | PFKFB3 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000235862 | PFKFB3 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BE495 | PFKFB3 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | PFKFB3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002367FA | PFKFB3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000383DF4 | PFKFB3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00006097A6 | PFKFB3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D4A78 | PFKFB3 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC379 | PFKFB3 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| URS0000345DEB | PFKFB3 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | PFKFB3 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| URS000012930C | PFKFB3 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| URS000016FF9C | PFKFB3 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKAA1 | PFKFB3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPKAPK2 | PFKFB3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKACA | PFKFB3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCA | PFKFB3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| IKBKB | PFKFB3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AKT1 | PFKFB3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HIF1A | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| PFKFB2 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| UBB | PFKFB3 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| UBC | PFKFB3 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| RPS27A | PFKFB3 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| UBA52 | PFKFB3 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| CBFA2T3 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| ARRB1 | PFKFB3 | 17620599 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CUL2 | PFKFB3 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ARRB2 | PFKFB3 | 17620599 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| EGFR | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| H3C1 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| MAGOH | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| PES1 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| EIF4A3 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| CLUH | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| CYLD | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| MTMR8 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| ARNT | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| ASB12 | PFKFB3 | 25348397 | N/A | physical interaction | ComPPI |
| PFKFB3 | PFKFB4 | 25348397 | N/A | physical interaction | ComPPI |
| PFKFB3 | PFKFB1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PFKFB3 | PFKFB3 | 16316985 24234451 | N/A | x-ray crystallography | IntAct |
| PRKAA2 | PFKFB3 | 12065600 18669648 19690332 27898060 | N/A | N/A | OmniPath |
| PRKCA | PFKFB3 | 15896703 27898060 | N/A | N/A | OmniPath |
| AKT1 | PFKFB3 | 15896703 27898060 | stimulant | N/A | OmniPath |
| CSNK2A1 | PFKFB3 | 12065600 27898060 9836440 | N/A | N/A | OmniPath |
| PRKAA1 | PFKFB3 | 12065600 27898060 | stimulant | N/A | OmniPath |