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GENE：PIAS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIAS2
FullNmae protein inhibitor of activated STAT 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17311
EnsembleID ENSG00000078043
Uniprot O75928

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIAS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PIAS2 GO:0003677,GO:0003712,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006351,GO:0006357,GO:0008270,GO:0016605,GO:0016607,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0019789,GO:0031625,GO:0060766,GO:0061629,GO:0061665,GO:0061665

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIAS2 hsa:9063 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
PIAS2 hsa:9063 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIAS2 UBE2I 12764129 23180781 sumoylation,physical association sumoylation reaction InnateDB
PIAS2 UBA2 12764129 23180781 sumoylation,physical association sumoylation reaction InnateDB
PIAS2 SAE1 12764129 23180781 sumoylation,physical association sumoylation reaction InnateDB
PIAS2 STAT1 12764129 23180781 sumoylation sumoylation reaction InnateDB
PIAS2 SUMO1 12764129 23180781 sumoylation,physical association sumoylation reaction InnateDB
PIAS2 AR 12764129 23180781 physical association sumoylation reaction InnateDB
PIAS2 RUFY1 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TRIM23 PIAS2 23180781 25416956 physical association two hybrid InnateDB
PIAS2 STAT4 12716907 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SNIP1 PIAS2 20005715 interaction type N/A PSP
SNIP1 PIAS2 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PIAS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PIAS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 PIAS2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PIAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PIAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PIAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PIAS2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000075994C PIAS2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 PIAS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 PIAS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A PIAS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 PIAS2 19536157 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000183BED PIAS2 19536157 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC864 PIAS2 19536157 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BA274 PIAS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 PIAS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A PIAS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A PIAS2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000011DF PIAS2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PIAS2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032FC1A PIAS2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000753AD PIAS2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000032BD73 PIAS2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000F31F4 PIAS2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000043C1C3 PIAS2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TXLNA PIAS2 25348397 N/A two hybrid ComPPI
GOLGA2 PIAS2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 ZBED1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 UBE2I 12177000 14525934 16189514 19549727 20936779 21988832 24234451 25348397 25416956 colocalization,physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,confocal microscopy,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PIAS2 TSR2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 ZBTB8A 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 ACY3 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 SNIP1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIAS2 AR 11117529 12177000 14525934 25348397 9920921 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PIAS2 STAT4 12716907 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIAS2 GTF2I 12193603 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PIAS2 PARK7 11477070 12526767 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PIAS2 GTF2IRD1 12193603 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PIAS2 HDAC3 12239342 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIAS2 PIAS1 11877418 14525934 24234451 25241761 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
PIAS2 ELK1 14525934 15920481 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PIAS2 SUMO1 14525934 14609633 21988832 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PIAS2 GRM8 14525934 16144832 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIAS2 NAV2 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PIAS2 MSX2 14525934 25348397 9256341 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PIAS2 SMAD4 14514699 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIAS2 MBD1 14525934 17066076 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PIAS2 DDX39B 14525934 14667819 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
PIAS2 CHMP4B 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIAS2 DNMT3A 25348397 N/A physical interaction ComPPI
PIAS2 ESR1 25348397 N/A physical interaction ComPPI
PIAS2 ESR2 25348397 N/A physical interaction ComPPI
PIAS2 NR3C1 25348397 N/A physical interaction ComPPI
PIAS2 PGR 25348397 N/A physical interaction ComPPI
PIAS2 SIAH1 25348397 N/A physical interaction ComPPI
PIAS2 SIAH2 25348397 N/A physical interaction ComPPI
PIAS2 AKT1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PIAS2 GLUL 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PIAS2 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PIAS2 MITF 25348397 N/A physical interaction ComPPI
PIAS2 TRIM27 25348397 N/A physical interaction ComPPI
PIAS2 TP53 18624398 24234451 25241761 25348397 physical association two hybrid,physical interaction,proximity ligation assay ComPPI,IntAct
PIAS2 JUN 25348397 N/A physical interaction ComPPI
PIAS2 MYC 17418410 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS2 HIC1 17283066 23704280 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PIAS2 HUWE1 25348397 N/A physical interaction ComPPI
PIAS2 MAPK8 25348397 N/A physical interaction ComPPI
PIAS2 TRAF2 25348397 N/A two hybrid,physical interaction ComPPI
PIAS2 PML 25348397 N/A physical interaction ComPPI
PIAS2 IFIH1 25348397 N/A physical interaction ComPPI
PIAS2 CLDN2 25348397 N/A physical interaction ComPPI
PIAS2 FLI1 25348397 N/A physical interaction ComPPI
PIAS2 SUMO2 25348397 N/A physical interaction ComPPI
PIAS2 CDKN2A 25348397 N/A physical interaction ComPPI
PIAS2 CDKN2A 25348397 N/A physical interaction ComPPI
PIAS2 SMAD3 25348397 N/A physical interaction ComPPI
PIAS2 PLAG1 25348397 N/A physical interaction ComPPI
PIAS2 PLAGL1 25348397 N/A physical interaction ComPPI
PIAS2 PAXIP1 25348397 N/A physical interaction ComPPI
PIAS2 RUFY1 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
PIAS2 ADA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIAS2 C1QA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIAS2 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS2 TICAM2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIAS2 SUMO3 25348397 N/A physical interaction ComPPI
PIAS2 CTBP1 25348397 N/A physical interaction ComPPI
PIAS2 PRKAB2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 TRIM63 25348397 N/A physical interaction ComPPI
PIAS2 TRIM55 25348397 N/A physical interaction ComPPI
PIAS2 MAPKAPK2 25348397 N/A physical interaction ComPPI
PIAS2 TRIM23 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 PHC1 25348397 N/A physical interaction ComPPI
PIAS2 GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 MX2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 CCNDBP1 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 CCHCR1 25348397 N/A physical interaction ComPPI
PIAS2 ARNT 25348397 N/A physical interaction ComPPI
PIAS2 ZNF451 25348397 N/A physical interaction ComPPI
PIAS2 CDCA8 25348397 N/A physical interaction ComPPI
PIAS2 LMNB1 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS2 CDKN2B 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PIAS2 LMNA 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PIAS2 TOPBP1 17006541 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PIAS2 NEDD8 18274552 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PIAS2 PARP1 25348397 N/A anti tag coimmunoprecipitation ComPPI
PIAS2 EPAS1 25348397 N/A anti tag coimmunoprecipitation ComPPI
PIAS2 RACK1 22210188 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
PIAS2 SUMO1P1 24234451 25348397 25416956 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 CHMP1A 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
PIAS2 CHMP5 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
PIAS2 PRKRA 25348397 N/A two hybrid ComPPI
PIAS2 NME7 25348397 N/A two hybrid ComPPI
PIAS2 UBASH3B 25348397 N/A two hybrid ComPPI
PIAS2 HMG20B 25348397 N/A two hybrid ComPPI
PIAS2 EDC3 25348397 N/A two hybrid ComPPI
PIAS2 CREB1 25348397 N/A two hybrid ComPPI
PIAS2 FAM118B 25348397 N/A two hybrid ComPPI
PIAS2 PAICS 25348397 N/A two hybrid ComPPI
PIAS2 UBQLN1 25348397 N/A two hybrid ComPPI
PIAS2 TRAF5 25348397 N/A two hybrid ComPPI
PIAS2 RFX2 25348397 N/A two hybrid ComPPI
PIAS2 HOMER1 25348397 N/A two hybrid ComPPI
PIAS2 ZNRD2 25348397 N/A two hybrid ComPPI
PIAS2 CBSL 25348397 N/A two hybrid ComPPI
PIAS2 HMG20A 25348397 N/A two hybrid ComPPI
PIAS2 C5ORF24 25348397 N/A two hybrid ComPPI
PIAS2 CGGBP1 25348397 N/A two hybrid ComPPI
PIAS2 SPINDOC 25348397 N/A two hybrid ComPPI
PIAS2 DEUP1 25348397 N/A two hybrid ComPPI
PIAS2 FKBP6 25348397 N/A two hybrid ComPPI
PIAS2 MX1 25348397 N/A two hybrid ComPPI
PIAS2 PRPH 25348397 N/A two hybrid ComPPI
PIAS2 ZBTB16 25348397 N/A two hybrid ComPPI
PIAS2 ZC3H10 25348397 N/A two hybrid ComPPI
PIAS2 HNRNPUL1 25348397 N/A two hybrid ComPPI
PIAS2 HOOK1 25348397 N/A two hybrid ComPPI
PIAS2 HMBOX1 25348397 N/A two hybrid ComPPI
PIAS2 GRHL2 25348397 N/A two hybrid ComPPI
PIAS2 EXOSC8 25348397 N/A two hybrid ComPPI
PIAS2 DES 25348397 N/A two hybrid ComPPI
PIAS2 HNRNPCL1 25348397 N/A two hybrid ComPPI
PIAS2 DMC1 25348397 N/A two hybrid ComPPI
PIAS2 ATF2 25348397 N/A two hybrid ComPPI
PIAS2 ZNF319 25348397 N/A two hybrid ComPPI
PIAS2 LCE2C 25348397 N/A two hybrid ComPPI
PIAS2 LCE1E 25348397 N/A two hybrid ComPPI
PIAS2 ZFP42 25348397 N/A two hybrid ComPPI
PIAS2 SEC23A 25348397 N/A two hybrid ComPPI
PIAS2 HMGXB4 25348397 N/A two hybrid ComPPI
PIAS2 TRIM50 25348397 N/A two hybrid ComPPI
PIAS2 TRAF3 25348397 N/A two hybrid ComPPI
PIAS2 PIAS2 24234451 25416956 physical association two hybrid array IntAct
PIAS2 UXT 25434787 27898060 N/A N/A OmniPath
PIAS2 PPARG 15123625 27898060 N/A N/A OmniPath
SUMO1 PIAS2 12764129 14609633 15388847 16204249 16524884 19217413 21988832 25416956 27898060 N/A N/A OmniPath
PIAS2 AR 11117529 12177000 12764129 27898060 9920921 inhibition N/A OmniPath
SRF PIAS2 12764129 27898060 N/A N/A OmniPath
PIAS2 STAT4 12716907 27898060 inhibition,stimulant N/A OmniPath
PIAS2 RUFY1 21988832 27898060 N/A N/A OmniPath
PIAS2 PARK7 11477070 12526767 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AF65A PIAS2 27087310 direct interaction,inhibition N/A NPInter

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