GENE：PIKFYVE
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PIKFYVE |
| FullNmae | phosphoinositide kinase, FYVE-type zinc finger containing |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:23785 |
| EnsembleID | ENSG00000115020 |
| Uniprot | Q9Y2I7 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PIKFYVE | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PIKFYVE | autophagy | 39932818 | PIKfyve inhibition effectively blocks autophagy in multiple models of KRAS-mutant pancreatic cancer and can synergize with inhibitors of members of the RAS-MAPK pathway, providing an effective combination strategy for pancreatic cancer. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PIKFYVE | GO:0000139,GO:0000285,GO:0000285,GO:0000285,GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0005911,GO:0006612,GO:0006661,GO:0008270,GO:0010008,GO:0012506,GO:0016308,GO:0019065,GO:0019886,GO:0030593,GO:0030593,GO:0030670,GO:0031410,GO:0031901,GO:0031901,GO:0031902,GO:0032288,GO:0032438,GO:0032438,GO:0034504,GO:0035556,GO:0036092,GO:0036289,GO:0042147,GO:0043813,GO:0045121,GO:0048471,GO:0052810,GO:0052810,GO:0052810,GO:0090382,GO:0090385,GO:0090385,GO:0106310,GO:1903100,GO:1903426,GO:1903426,GO:1904562,GO:1904562,GO:2000785 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PIKFYVE | hsa:200576 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| PIKFYVE | hsa:200576 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PIKFYVE | hsa:200576 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| PIKFYVE | hsa:200576 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| PIKFYVE | hsa:200576 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | PIKFYVE | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | PIKFYVE | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PIKFYVE | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | PIKFYVE | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PIKFYVE | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PIKFYVE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PIKFYVE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PIKFYVE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PIKFYVE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PIKFYVE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PIKFYVE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000EC1BE | PIKFYVE | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000005481D | PIKFYVE | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005FDE70 | PIKFYVE | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001A405B | PIKFYVE | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002E177F | PIKFYVE | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | PIKFYVE | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | PIKFYVE | 25416803 26302821 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| WDR83 | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| ANK1 | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| CDK5 | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| TIMM23 | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| RABEPK | PIKFYVE | 14525934 14530284 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| LCAT | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| TGOLN2 | PIKFYVE | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| PIKFYVE | VAC14 | 19037259 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| PIKFYVE | BCL6 | 25348397 | N/A | physical interaction | ComPPI |
| PIKFYVE | APP | 25348397 | N/A | physical interaction | ComPPI |
| PIKFYVE | FIG4 | 25348397 | N/A | physical interaction | ComPPI |
| PIKFYVE | NBEAL2 | 24234451 25348397 29187380 | association | tandem affinity purification | ComPPI,IntAct |
| NPM1 | PIKFYVE | 24234451 30021884 | physical association | cross-linking study | IntAct |
| SPAG9 | PIKFYVE | 19056739 27898060 | N/A | N/A | OmniPath |
| PRKG1 | PIKFYVE | 15546921 27898060 | N/A | N/A | OmniPath |
| AKT1 | PIKFYVE | 15546921 18669648 27898060 | stimulant | N/A | OmniPath |
| SGK1 | PIKFYVE | 23757022 27898060 | N/A | N/A | OmniPath |