GENE：PLAT
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLAT |
| FullNmae | plasminogen activator, tissue type |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9051 |
| EnsembleID | ENSG00000104368 |
| Uniprot | P00750 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLAT | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLAT | GO:0001666,GO:0004252,GO:0004252,GO:0004252,GO:0005102,GO:0005515,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006508,GO:0007596,GO:0009986,GO:0010757,GO:0014909,GO:0030141,GO:0031639,GO:0031639,GO:0036211,GO:0042730,GO:0045177,GO:0045861,GO:0048008,GO:0051219,GO:0051918,GO:0060468,GO:0070062,GO:0097180,GO:0098685,GO:0098978,GO:0099183 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PLAT | hsa:5327 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| PLAT | hsa:5327 | path:hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| PLAT | hsa:5327 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| PLAT | hsa:5327 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| PLAT | hsa:5327 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PLAT | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| GATA1 | PLAT | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PLAT | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PLAT | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| RARA | PLAT | 18971253 19538480 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| RARB | PLAT | 19538480 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| RXRA | PLAT | 19538480 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | PLAT | 18419748 21437359 9851700 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SP3 | PLAT | 21437359 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| FOXP3 | PLAT | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CREB1 | PLAT | 18971253 8647095 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | PLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF2 | PLAT | 8647095 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREM | PLAT | 9851700 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | PLAT | 1963081 9851700 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUND | PLAT | 9851700 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NF1 | PLAT | 15044208 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | PLAT | 21437359 9851700 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ELK1 | PLAT | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | PLAT | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | PLAT | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | PLAT | 21131358 | rna interference,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000029D9F1 | PLAT | 21282569 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000009262D | PLAT | 21131358 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | PLAT | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK1 | PLAT | 14525934 15861134 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPK3 | PLAT | 14525934 15861134 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PLG | PLAT | 11928826 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| F2 | PLAT | 25348397 | N/A | physical interaction | ComPPI |
| SERPINB6 | PLAT | 25348397 | N/A | physical interaction | ComPPI |
| F10 | PLAT | 11371191 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| SERPINE1 | PLAT | 14525934 2110366 22449964 24234451 25348397 3090045 8607113 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo,comigration in gel electrophoresis | ComPPI,HPRD,IntAct |
| PLAT | SPARC | 14525934 25348397 2745554 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PLAT | CLEC3B | 12694198 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PLAT | LAMA3 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| PLAT | SERPINA5 | 14525934 25348397 2551064 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PLAT | SERPING1 | 14525934 25348397 27898060 7586269 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| PLAT | LRP1B | 11384978 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PLAT | LRP1 | 10632583 14525934 1502153 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| PLAT | CALR | 14525934 25348397 27898060 9359841 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| PLAT | GRIN1 | 14525934 15448144 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| PLAT | FGA | 11170397 14525934 25348397 3088041 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| PLAT | KRT8 | 14525934 25348397 27898060 9988531 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| PLAT | LAMA1 | 14525934 25348397 8360181 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PLAT | ANXA2 | 11978811 12468550 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| PLAT | PLAU | 14525934 25348397 7721771 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| PLAT | FN1 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | TERF2 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | POT1 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | PDGFC | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | DCN | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | PTPRK | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | IFNA14 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | SERPINA10 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | SERPINE2 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
| HMGB1 | PLAT | 14525934 1909331 25348397 27898060 8366113 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |