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GENE：PLAUR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLAUR
FullNmae plasminogen activator, urokinase receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9053
EnsembleID ENSG00000011422
Uniprot Q03405

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLAUR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLAUR apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLAUR apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PLAUR GO:0001934,GO:0005102,GO:0005515,GO:0005576,GO:0005788,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006935,GO:0007165,GO:0007596,GO:0009897,GO:0009986,GO:0010755,GO:0016020,GO:0019898,GO:0019899,GO:0019904,GO:0030155,GO:0030162,GO:0030377,GO:0034112,GO:0035579,GO:0038023,GO:0038195,GO:0042995,GO:0043066,GO:0043388,GO:0045742,GO:0051917,GO:0090200,GO:0098637,GO:1905370,GO:2001243,GO:2001268

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLAUR hsa:5329 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
PLAUR hsa:5329 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JAK1 PLAUR 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
PLAU PLAUR 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
PLAUR ITGB5 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
FAP PLAUR 21051638 23402812 24778314 25593080 26192618 27216177 7911242 interaction type N/A ACSN
PLAUR NFKB2 10824110 23180781 physical association electrophoretic mobility supershift assay InnateDB
ITGB2 PLAUR 18644795 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR1 PLAUR 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLAUR LYN 23180781 9417082 physical association anti tag coimmunoprecipitation InnateDB
PAF1 PLAUR 23180781 26217014 physical association anti tag coimmunoprecipitation InnateDB
RTF1 PLAUR 23180781 26217014 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PLAUR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOSL2 PLAUR 11234878 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
GATA2 PLAUR 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
JUN PLAUR 10471035 11234878 16893520 17510314 8761947 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
JUND PLAUR 10471035 11234878 17510314 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SP1 PLAUR 11234878 14660675 16261846 17317820 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SP3 PLAUR 16261846 17317820 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
TCF7L2 PLAUR 19784072 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2A PLAUR 17317820 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOSL1 PLAUR 10471035 11234878 16893520 17510314 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
PRDM14 PLAUR 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP2 PLAUR 20858596 21711233 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PLAUR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLAUR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PLAUR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PLAUR 18971253 21283769 trascriptional regulation,stimulation inferred by curator TFlink
FOS PLAUR 10471035 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PLAUR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PLAUR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PLAUR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 PLAUR 12369939 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 PLAUR 11234878 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 PLAUR 12244126 19020743 trascriptional regulation,stimulation inferred by curator TFlink
RELA PLAUR 12244126 19020743 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PLAUR 11234878 14660675 16261846 17317820 trascriptional regulation,stimulation inferred by curator TFlink
SPDEF PLAUR 12907642 trascriptional regulation,stimulation inferred by curator TFlink
E2F2 PLAUR N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F3 PLAUR N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 PLAUR 21282569 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 PLAUR 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001EFBE3 PLAUR 25416803 26082201 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 PLAUR 25416803 26082201 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
TYK2 PLAUR 25361965 interaction type N/A PTMCode2
PLAUR TYK2 25361965 interaction type N/A PTMCode2
KNG1 PLAUR 25361965 interaction type N/A PTMCode2
PLAUR KNG1 25361965 interaction type N/A PTMCode2
ITGB2 PLAUR 25361965 interaction type N/A PTMCode2
PLAUR ITGB2 25361965 interaction type N/A PTMCode2
PLAUR IGF2R 25361965 interaction type N/A PTMCode2
IGF2R PLAUR 25361965 interaction type N/A PTMCode2
PLAUR SRPX2 25361965 interaction type N/A PTMCode2
SRPX2 PLAUR 25361965 interaction type N/A PTMCode2
PLAUR HCK 25361965 interaction type N/A PTMCode2
HCK PLAUR 25361965 interaction type N/A PTMCode2
PLAUR JAK2 25361965 interaction type N/A PTMCode2
JAK2 PLAUR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FASTKD3 PLAUR 25348397 N/A physical interaction ComPPI
TYK2 PLAUR 14525934 25348397 9974409 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TXNDC17 PLAUR 25348397 N/A physical interaction ComPPI
IL6ST PLAUR 14525934 25348397 27898060 9353320 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
LYN PLAUR 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
ITGB1 PLAUR 25348397 N/A in vivo ComPPI
PKN1 PLAUR 25348397 N/A physical interaction ComPPI
JAK1 PLAUR 14525934 25348397 9417082 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KNG1 PLAUR 14525934 14764580 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
VTN PLAUR 14525934 25348397 8830783 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LRP1B PLAUR 11384978 12194987 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PLAUR FAP 12376466 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PLAUR MMP12 12195704 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PLAUR LRP1 11359936 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PLAUR ITGAM 10744708 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PLAUR EEF1A1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PLAUR SURF2 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PLAUR PFN2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PLAUR SRPX2 14525934 18718938 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PLAUR FYN 14525934 25348397 9417082 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PLAUR HCK 11097855 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PLAUR EEF1A1P5 25348397 N/A physical interaction ComPPI
PLAUR PLAU 11501527 14525934 24234451 24457100 25348397 3023326 3031025 physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction ComPPI,HPRD,IntAct
PLAUR IGF2R 25348397 N/A physical interaction ComPPI
PLAUR PSAP 25348397 N/A physical interaction ComPPI
PLAUR OXCT1 25348397 N/A physical interaction ComPPI
PLAUR CTSA 25348397 N/A physical interaction ComPPI
PLAUR CTTN 25348397 N/A physical interaction ComPPI
PLAUR SELENBP1 25348397 N/A physical interaction ComPPI
PLAUR SCAF4 25348397 N/A physical interaction ComPPI
PLAUR VMA21 25348397 N/A physical interaction ComPPI
PLAUR HDLBP 25348397 N/A physical interaction ComPPI
PLAUR SDHAF2 25348397 N/A physical interaction ComPPI
PLAUR UBQLN2 25348397 N/A physical interaction ComPPI
PLAUR WDHD1 25348397 N/A physical interaction ComPPI
PLAUR NOTCH2 25348397 N/A physical interaction ComPPI
PLAUR TBCA 25348397 N/A physical interaction ComPPI
PLAUR ELAVL1 25348397 N/A physical interaction ComPPI
PLAUR TEX101 25348397 N/A physical interaction ComPPI
PLAUR MC1R 25348397 N/A physical interaction ComPPI
PLAUR TUBB3 25348397 N/A physical interaction ComPPI
PLAUR LARGE2 25348397 N/A physical interaction ComPPI
PLAUR LARGE1 25348397 N/A physical interaction ComPPI
PLAUR PXDN 25348397 N/A physical interaction ComPPI
PLAUR ZNF146 25348397 N/A physical interaction ComPPI
PLAUR MBTPS1 25348397 N/A physical interaction ComPPI
PLAUR DNA2 25348397 N/A physical interaction ComPPI
PLAUR TAZ 25348397 N/A physical interaction ComPPI
PLAUR LAMB2 25348397 N/A physical interaction ComPPI
PLAUR POGLUT1 25348397 N/A physical interaction ComPPI
PLAUR ARSA 25348397 N/A physical interaction ComPPI
PLAUR GALNS 25348397 N/A physical interaction ComPPI
PLAUR EXT1 25348397 N/A physical interaction ComPPI
PLAUR CHSY1 25348397 N/A physical interaction ComPPI
PLAUR CHSY3 25348397 N/A physical interaction ComPPI
PLAUR DDX12P 25348397 N/A physical interaction ComPPI
PLAUR DDX11 25348397 N/A physical interaction ComPPI
PLAUR TUBA1A 25348397 N/A physical interaction ComPPI
PLAUR LOXL2 25348397 N/A physical interaction ComPPI
PLAUR ADCK1 25348397 N/A physical interaction ComPPI
PLAUR MAN2A1 25348397 N/A physical interaction ComPPI
PLAUR SPCS2 25348397 N/A physical interaction ComPPI
PLAUR EOGT 25348397 N/A physical interaction ComPPI
PLAUR NAGLU 25348397 N/A physical interaction ComPPI
PLAUR DNAJB9 25348397 N/A physical interaction ComPPI
PLAUR NDST2 25348397 N/A physical interaction ComPPI
PLAUR NDST1 25348397 N/A physical interaction ComPPI
PLAUR SGSH 25348397 N/A physical interaction ComPPI
PLAUR ARSK 25348397 N/A physical interaction ComPPI
PLAUR FUT11 25348397 N/A physical interaction ComPPI
PLAUR DARS2 25348397 N/A physical interaction ComPPI
PLAUR CNTNAP3B 25348397 N/A physical interaction ComPPI
PLAUR MAN1A1 25348397 N/A physical interaction ComPPI
PLAUR MGAT4B 25348397 N/A physical interaction ComPPI
PLAUR PI4K2B 25348397 N/A physical interaction ComPPI
PLAUR PCYOX1 25348397 N/A physical interaction ComPPI
PLAUR PCSK5 25348397 N/A physical interaction ComPPI
PLAUR CDYL 25348397 N/A physical interaction ComPPI
PLAUR MGAT5 25348397 N/A physical interaction ComPPI
PLAUR P3H3 25348397 N/A physical interaction ComPPI
PLAUR RPUSD3 25348397 N/A physical interaction ComPPI
PLAUR GCLM 25348397 N/A physical interaction ComPPI
PLAUR GALNT18 25348397 N/A physical interaction ComPPI
PLAUR ARSB 25348397 N/A physical interaction ComPPI
PLAUR HUS1 25348397 N/A physical interaction ComPPI
PLAUR MELK 25348397 N/A physical interaction ComPPI
PLAUR EMILIN3 25348397 N/A physical interaction ComPPI
PLAUR TATDN2 25348397 N/A physical interaction ComPPI
PLAUR CERCAM 25348397 N/A physical interaction ComPPI
PLAUR DHFR2 25348397 N/A physical interaction ComPPI
PLAUR TRMT11 25348397 N/A physical interaction ComPPI
PLAUR PRORP 25348397 N/A physical interaction ComPPI
PLAUR HOXD13 25348397 N/A physical interaction ComPPI
PLAUR DHRS4 25348397 N/A physical interaction ComPPI
PLAUR MANEA 25348397 N/A physical interaction ComPPI
PLAUR NOCT 25348397 N/A physical interaction ComPPI
PLAUR PLTP 25348397 N/A physical interaction ComPPI
PLAUR NR2F2 25348397 N/A physical interaction ComPPI
PLAUR ST3GAL4 25348397 N/A physical interaction ComPPI
PLAUR UBE3A 25348397 N/A physical interaction ComPPI
PLAUR PPOX 25348397 N/A physical interaction ComPPI
PLAUR MAN2A2 25348397 N/A physical interaction ComPPI
PLAUR NEK4 25348397 N/A physical interaction ComPPI
PLAUR EGFL7 25348397 N/A physical interaction ComPPI
PLAUR PCYOX1L 25348397 N/A physical interaction ComPPI
PLAUR XRCC3 25348397 N/A physical interaction ComPPI
PLAUR MCM9 25348397 N/A physical interaction ComPPI
PLAUR TOP2B 25348397 N/A physical interaction ComPPI
PLAUR GLB1 25348397 N/A physical interaction ComPPI
PLAUR TUBA4A 25348397 N/A physical interaction ComPPI
PLAUR BMP8B 25348397 N/A physical interaction ComPPI
PLAUR TXNDC16 25348397 N/A physical interaction ComPPI
PLAUR FGR 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
PLAUR SUMO2 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PLAUR ANG 24234451 24457100 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,fluorescence microscopy,proximity ligation assay ComPPI,IntAct
PLAUR S100A10 24234451 24457100 25348397 colocalization fluorescence microscopy ComPPI,IntAct
ITGB2 PLAUR 25348397 N/A physical interaction ComPPI
POMGNT2 PLAUR 25348397 N/A physical interaction ComPPI
PLAUR LYN 27898060 9417082 N/A N/A OmniPath
FN1 PLAUR 2413022 27898060 N/A N/A OmniPath
PLAUR ITGB3 27383564 27898060 stimulant N/A OmniPath
PLAUR KRT1 14691569 27898060 stimulant N/A OmniPath
PLAU PLAUR 11501527 16456079 16879932 18376415 19017363 27898060 3023326 3031025 stimulant N/A OmniPath
MMP12 PLAUR 12195704 27898060 stimulant N/A OmniPath

Visualization










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