GENE：PLXNA2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLXNA2 |
| FullNmae | plexin A2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9100 |
| EnsembleID | ENSG00000076356 |
| Uniprot | O75051 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLXNA2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PLXNA2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLXNA2 | GO:0001756,GO:0002116,GO:0002116,GO:0005515,GO:0005886,GO:0005886,GO:0007162,GO:0008360,GO:0017154,GO:0017154,GO:0021915,GO:0021935,GO:0030334,GO:0030334,GO:0042802,GO:0043087,GO:0050772,GO:0051642,GO:0060037,GO:0060174,GO:0071526,GO:1902287 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PLXNA2 | hsa:5362 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PLXNA2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA1 | PLXNA2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PLXNA2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PLXNA2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | PLXNA2 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | PLXNA2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PLXNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | PLXNA2 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00005DEC41 | PLXNA2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BF7F9 | PLXNA2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CCD18 | PLXNA2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000254A6 | PLXNA2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A6D0C | PLXNA2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | PLXNA2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | PLXNA2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SLAMF1 | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| TNF | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| XAB2 | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| CCL22 | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| TAZ | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| NUFIP1 | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| OS9 | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| CD1E | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| UBAP2L | PLXNA2 | 12421765 14525934 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| PLXNA2 | HACE1 | 12421765 14525934 24234451 25348397 | physical association | two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| PLXNA2 | PTPRK | 25348397 | N/A | physical interaction | ComPPI |
| PLXNA2 | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
| PLXNA2 | DEFA5 | 25348397 | N/A | physical interaction | ComPPI |
| PLXNA2 | PDCD6IP | 12421765 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| PLXNB1 | PLXNA2 | 12559962 27898060 | N/A | N/A | OmniPath |
| SEMA6A | PLXNA2 | 18327254 27898060 | N/A | N/A | OmniPath |