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GENE：PRL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRL
FullNmae prolactin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9445
EnsembleID ENSG00000172179
Uniprot P01236

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRL immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRL GO:0001937,GO:0005148,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0007166,GO:0007565,GO:0007595,GO:0008284,GO:0016525,GO:0030879,GO:0031667,GO:0031904,GO:0046427,GO:0046427,GO:1902895,GO:1903489

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRL hsa:5617 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
PRL hsa:5617 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
PRL hsa:5617 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PRL hsa:5617 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PRL hsa:5617 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRL PAK2 11943200 23180781 phosphorylation reaction protein kinase assay InnateDB
PRL PRLR 10585417 10966654 15082796 16546209 18988627 20053995 21889455 23180781 23331499 24243840 29145629 7984244 9626554 stimulation,physical association x-ray crystallography,inferred by curator InnateDB,Reactome,SignaLink,SignaLink
PRL PRL 15082796 29145629 9006323 physical association inferred by curator Reactome
PRL GH2 15082796 29145629 physical association inferred by curator Reactome
PRL GH1 15082796 29145629 physical association inferred by curator Reactome
PRL CSH1 15082796 29145629 physical association inferred by curator Reactome
PRL CUL1 15082796 29145629 physical association inferred by curator Reactome
PRL SKP1 15082796 29145629 physical association inferred by curator Reactome
PRL BTRC 15082796 29145629 physical association inferred by curator Reactome
PRL STAT5A 24243840 29145629 physical association inferred by curator Reactome
PRL STAT5B 24243840 29145629 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
ESR1 PRL 18022314 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ESR2 PRL 18022314 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ETS1 PRL 12200232 20019798 21401636 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXO1 PRL 19727442 21401636 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HOXA11 PRL 19727442 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
POU1F1 PRL 11081207 11874696 16879162 17240357 17933456 18971253 19808898 7529501 7877625 9207961 9822660 trascriptional regulation,stimulation inferred by curator TFlink
TBP PRL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PRL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRL 17187171 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB PRL 10455153 trascriptional regulation,stimulation inferred by curator TFlink
CEBPD PRL 10455153 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 PRL 17187171 trascriptional regulation,stimulation inferred by curator TFlink
ERF PRL 9822660 trascriptional regulation,stimulation inferred by curator TFlink
EZH2 PRL 21903722 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 PRL 12609987 trascriptional regulation,stimulation inferred by curator TFlink
KLF12 PRL 23458459 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 PRL 17240357 trascriptional regulation,stimulation inferred by curator TFlink
LHX2 PRL 22535646 trascriptional regulation,stimulation inferred by curator TFlink
MEN1 PRL 17024155 trascriptional regulation,stimulation inferred by curator TFlink
PITX1 PRL 16879162 trascriptional regulation,stimulation inferred by curator TFlink
PITX2 PRL 16879162 trascriptional regulation,stimulation inferred by curator TFlink
PREB PRL 20411477 trascriptional regulation,stimulation inferred by curator TFlink
VDR PRL 10406465 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 PRL N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 PRL N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PPIB PRL 25361965 interaction type N/A PTMCode2
PRL PPIB 25361965 interaction type N/A PTMCode2
PRL PRLR 25361965 interaction type N/A PTMCode2
PRLR PRL 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPIB PRL 10935542 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PRLR PRL 10966654 14525934 25348397 7984244 9626554 N/A circular dichroism,experimental interaction detection,nuclear magnetic resonance,physical interaction,in vitro,in vivo ComPPI,HPRD
PRL LOX 25348397 N/A solid phase assay ComPPI
PRL UBQLN4 25348397 N/A physical interaction ComPPI
PRL HLA-DQB2 25348397 N/A physical interaction ComPPI
PRL BMP1 17548836 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRL PAK2 11943200 27898060 N/A N/A OmniPath
PAK2 PRL 11943200 15687336 19555049 27898060 stimulant N/A OmniPath
PRL PRLR 10585417 10966654 11356126 21889455 22325776 2558309 27898060 7984244 9626554 stimulant N/A OmniPath

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