GENE：PRTN3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PRTN3 |
| FullNmae | proteinase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9495 |
| EnsembleID | ENSG00000196415 |
| Uniprot | P24158 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PRTN3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PRTN3 | GO:0004252,GO:0004252,GO:0004252,GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006508,GO:0006508,GO:0006508,GO:0006509,GO:0008236,GO:0008284,GO:0019730,GO:0019899,GO:0030574,GO:0035578,GO:0035578,GO:0043231,GO:0043547,GO:0044853,GO:0045217,GO:0050765,GO:0062023,GO:0070062,GO:0072672,GO:0097029 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRTN3 | CAMP | 11389039 23180781 | cleavage reaction | protease assay | InnateDB |
| PRTN3 | EGR1 | 19032775 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL32 | PRTN3 | 16488976 23180781 | protein cleavage,physical association | surface plasmon resonance,protease assay | InnateDB |
| IL33 | PRTN3 | 22270365 22307629 23180781 | protein cleavage | protease assay | InnateDB |
| IL18 | PRTN3 | 22270365 23180781 | protein cleavage | protease assay | InnateDB |
| PRTN3 | CXCL14 | 23180781 25964486 | protein cleavage | protease assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYC | PRTN3 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| EGR1 | PRTN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | PRTN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PRTN3 | 10677505 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRTN3 | ITGB2 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB2 | PRTN3 | 25361965 | interaction type | N/A | PTMCode2 |
| PRTN3 | IL32 | 25361965 | interaction type | N/A | PTMCode2 |
| IL32 | PRTN3 | 25361965 | interaction type | N/A | PTMCode2 |
| PRTN3 | SERPINB1 | 25361965 | interaction type | N/A | PTMCode2 |
| SERPINB1 | PRTN3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMAD3 | PRTN3 | 14525934 15527767 24234451 25348397 | physical association | experimental interaction detection,pull down,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| F2RL1 | PRTN3 | 10978167 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| SERPINB13 | PRTN3 | 10512713 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SERPINA1 | PRTN3 | 12114510 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| F2R | PRTN3 | 10978167 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ITGB2 | PRTN3 | 12960243 25348397 27898060 | N/A | in vivo | ComPPI,OmniPath |
| TNF | PRTN3 | 10339575 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PRTN3 | CAMP | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PRTN3 | RELA | 12444202 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| PRTN3 | IL32 | 14525934 16488976 25348397 | N/A | experimental interaction detection,pull down,physical interaction,protease assay,in vitro,protein cleavage,surface plasmon resonance array | ComPPI,HPRD |
| PRTN3 | SERPINB1 | 12114510 14525934 25348397 27898060 7654387 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| PRTN3 | ELN | 11867344 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| PRTN3 | IL1B | 10339575 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PRTN3 | ITGAM | 25348397 | N/A | physical interaction | ComPPI |
| PRTN3 | A2M | 17174955 24234451 25348397 | colocalization | cosedimentation through density gradient | ComPPI,IntAct |
| CXCL14 | PRTN3 | 25964486 27898060 | N/A | N/A | OmniPath |
| PRTN3 | IL33 | 22270365 22307629 27898060 | N/A | N/A | OmniPath |
| PRTN3 | IL18 | 22270365 27898060 | N/A | N/A | OmniPath |